Co-beneldopa for Parkinson's disease

About co-beneldopa

You will have been prescribed co-beneldopa to relieve symptoms of مرض باركنسون. In Parkinson's disease, a number of cells in a small part of the brain, called the substantia nigra, become damaged and die. These brain cells pass messages down nerves in the spinal cord by producing a chemical called dopamine, and it is these messages which control the muscles of the body. As the cells in the substantia nigra are damaged, the amount of dopamine that is produced is reduced. A combination of the reduction of cells and a low level of dopamine in the cells in this part of the brain causes nerve messages to the muscles to become slowed and abnormal. This produces the main symptoms of Parkinson's disease, which are stiffness, shaking (tremor), and slowness of movement.

Co-beneldopa contains two ingredients, levodopa and benserazide. Once in the body, levodopa is converted into dopamine which helps to restore the level of dopamine in the damaged area of the brain. The benserazide ingredient helps to prevent the levodopa from being broken down into dopamine in parts of the body other than the brain. This means more levodopa gets into the brain to be converted into dopamine, and also it helps to reduce side-effects.

Some medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start taking co-beneldopa it is important that your doctor knows:

• If you have lung disease or a problem with your breathing.

• إذا كنت قد أصبت بقرحة في المعدة من قبل.

• If you have heart or blood vessel problems.

• If you have a problem with raised pressure in your eye (glaucoma).

• If you have ever had a fit (convulsion).

• إذا كان لديك أي مشاكل في طريقة عمل الكبد لديك، أو في طريقة عمل الكلى لديك.

• If you have a mental health problem.

• If you have ever had skin cancer.

• If you know you have any of the following: an overactive thyroid gland, Cushing's syndrome, diabetes, weakened bones (osteomalacia), or a growth on your adrenal glands, called phaeochromocytoma.

• إذا كنت حاملاً أو مرضعة.

• إذا كنت تتناول أي أدوية أخرى. يشمل ذلك أي أدوية تتناولها والتي يمكن شراؤها بدون وصفة طبية، بالإضافة إلى الأدوية العشبية والمكملات الغذائية.

• إذا كنت قد تعرضت في أي وقت مضى لرد فعل تحسسي تجاه دواء.

• Before you start the treatment, read the manufacturer's printed information leaflet from inside the pack and any additional information your doctor has given to you. These will give you more information about co-beneldopa and will provide you with a full list of the side-effects which you may experience from taking it.

• Take co-beneldopa exactly as your doctor tells you to. It is usually taken three or four times each day, but your doctor will prescribe a dose that best suits you and will tell you how much to take and when to take it. You will be started on a low dose at first, but your dose over time will most likely need to be increased to control your symptoms.

• Try to take co-beneldopa at the same times of day each day as this will help you to remember to take it regularly. If you do miss a dose, take your next dose when it is due but leave out the missed dose. Do not take two doses together to make up for a forgotten dose.

• If you are taking immediate-release co-beneldopa capsules (Madopar® capsules):

  • Take your doses either half an hour before or one hour after a meal.

• If you are taking prolonged-release co-beneldopa capsules (Madopar® CR capsules):

  • Swallow the capsule whole, preferably with a drink of water - do not chew or open the capsules.

  • Take your doses either half an hour before or one hour after a meal.

  • Antacid medicines will stop your body from absorbing the full dose of co-beneldopa, so if you should need to take an indigestion remedy, avoid taking it during the two hours before you take a dose, and during the two hours afterwards.

• If you are taking co-beneldopa dispersible tablets (Madopar® tablets):

  • You can swallow the tablets whole, or you can take them mixed into a small glass of water or fruit squash (but not pure fruit juice).

  • Take your doses either half an hour before or one hour after a meal.

• Try to keep your regular appointments with your doctor. This is so your doctor can check on your progress. During the first few weeks of treatment in particular, your dose may require adjusting.

• Make sure you know exactly when to take your medication. Dose schedules and timings are important. Your pharmacist will be able to advise and help if you have difficulty in getting tablets/capsules out of blister packs, or if you have difficulty in remembering when to take your doses.

• Co-beneldopa capsules and tablets are available in several different strengths. Each time you collect a fresh supply, it's a good idea to check the strength on the pack to make sure they are what you are expecting. If you are unsure, ask your pharmacist for advice.

• Co-beneldopa can make your urine look a dark reddish colour. Your saliva, teeth or tongue may also be affected. This is harmless and is nothing to worry about. It is caused by your body getting rid of the medicine.

• If you take any medicines that you have bought without a prescription, check with a pharmacist that they are suitable to take with co-beneldopa. This is because some medicines, such as iron and some vitamins, may interfere with it.

• Sometimes people taking co-beneldopa can fall asleep suddenly with little or no warning of being tired beforehand. Until you know how you react, take extra care if you drive and if you operate machinery. If you do find yourself falling asleep suddenly, you should see your doctor as soon as possible for advice, and avoid driving or using tools and machines in the meantime.

• حافظ على نشاطك قدر الإمكان ومارس التمارين بانتظام بقدر ما تستطيع. قد تمشي ببطء أكثر من ذي قبل، لكن المشي اليومي هو تمرين جيد وقد يساعد في تخفيف تصلب العضلات.

• If you are a driver you should tell the DVLA and your insurance company that you have Parkinson's disease. Depending on the severity of symptoms and the medicines that you are taking, you may still be allowed to drive following a medical assessment.

• Treatment with medicines containing levodopa can sometimes cause problems with أنواع السلوك الاندفاعي. إذا لاحظت أي تغييرات في سلوكك، مثل زيادة الرغبة في المقامرة، أو الأكل بشراهة، أو الإنفاق بشكل مفرط، أو زيادة الرغبة الجنسية، يجب عليك إبلاغ طبيبك في أقرب وقت ممكن.

• If you are due to have an operation or dental treatment, tell the person carrying out the treatment that you are taking co-beneldopa because there could be an increased risk of problems with some anaesthetics. Also, if you need to have any blood or urine tests, you must say that you are taking co-beneldopa, because it can affect the result of some tests.

• Co-beneldopa can harm an unborn child so you must avoid getting pregnant while you are taking co-beneldopa. Make sure you have discussed with your doctor which types of contraception are suitable for you and your partner. You may be advised to have a pregnancy test before starting treatment with co-beneldopa.

• There is a small increased risk of skin problems developing in people with Parkinson's disease, although the cause of this is unclear. It is a good idea to check your skin from time to time for any unusual patches, and to speak with your doctor if you are concerned.

• Continue to take co-beneldopa regularly. Stopping treatment suddenly can cause serious problems. Your doctor will probably want you to reduce your dose gradually if this becomes necessary.

The table below contains some of the common side-effects associated with co-beneldopa. You will find a full list in the manufacturer's information leaflet supplied with your medicine. Side-effects can sometimes occur when you first start taking levodopa, although most people have no problems with low doses. Unfortunately, most people taking levodopa over time (typically after several years) develop problems. These include muscle problems which can cause uncontrollable jerky movements, and 'on-off' effects (see below).

If you experience any other symptoms which you think may be due to co-beneldopa, speak with your doctor or pharmacist for further advice.

• احفظ جميع الأدوية بعيدًا عن متناول ورؤية الأطفال.

• احفظه في مكان بارد وجاف، بعيدًا عن الحرارة المباشرة والضوء.