Hereditary diffuse gastric cancer
آخر تحديث 21 Mar 2023
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Hereditary diffuse gastric cancer (HDGC) is an inherited disorder that greatly increases the chance of developing a form of stomach(gastric) cancer. In this form, known as diffuse gastric cancer, there is no solid tumour. Instead cancerous (malignant) cells multiply underneath the stomach lining, making the lining thick and rigid. The invasive nature of this type of cancer makes it highly likely that these cancer cells will spread (metastasize) to other tissues, such as the liver or nearby bones.
الوصف
Hereditary diffuse gastric cancer (HDGC) is an inherited disorder that greatly increases the chance of developing a form of stomach(gastric) cancer. In this form, known as diffuse gastric cancer, there is no solid tumour. Instead cancerous (malignant) cells multiply underneath the stomach lining, making the lining thick and rigid. The invasive nature of this type of cancer makes it highly likely that these cancer cells will spread (metastasize) to other tissues, such as the liver or nearby bones.
Symptoms of diffuse gastric cancer occur late in the disease and can include stomach pain, nausea, vomiting, difficulty swallowing (dysphagia), decreased appetite, and weight loss. If the cancer metastasizes to other tissues, it may lead to an enlarged liver, yellowing of the eyes and skin (jaundice), an abnormal buildup of fluid in the abdominal cavity (ascites), firm lumps under the skin, or broken bones.
In HDGC, gastric cancer usually occurs in a person's late thirties or early forties, although it can develop anytime during adulthood. If diffuse gastric cancer is detected early, the survival rate is high; however, because this type of cancer is hidden underneath the stomach lining, it is usually not diagnosed until the cancer has become widely invasive. At that stage of the disease, the survival rate is approximately 20 percent.
Some people with HDGC have an increased risk of developing other types of cancer, such as a form of breast cancer in women that begins in the milk-producing glands (lobular breast cancer); prostate cancer; and cancers of the colon (large intestine) and rectum, which are collectively referred to as colorectal cancer. Most people with HDGC have family members who have had one of the types of cancer associated with HDGC. In some families, all the affected members have diffuse gastric cancer. In other families, some affected members have diffuse gastric cancer and others have another associated form of cancer, such as lobular breast cancer. Frequently, HDGC-related cancers develop in individuals before the age of 50.
Inheritance patterns
The source lists the following possible inheritance patterns: Autosomal dominant. More than one pattern can apply in different cases.
Related genes
Other names
E-cadherin-associated hereditary gastric cancer
Familial diffuse gastric cancer
FDGC
HDGC
Hereditary diffuse gastric adenocarcinoma
Related patient information and medicines
Patient information leaflet
سرطان الأمعاء
Colon cancer and rectal cancer (also called colorectal cancer) are common in the UK. If bowel cancer is diagnosed at an early stage, there is a good chance of a cure. If a close relative has had bowel cancer (there is some genetic factor). If you have a genetic condition that causes bowel cancer, such as familial adenomatous polyposis (FAP) or.
Patient information leaflet
سرطان المعدة
على الرغم من stomach (gastric) cancer هو common worldwide, it is not so common in the UK. Most cases occur in people over the age of 55. If stomach cancer is diagnosed at an early stage, there is a good chance of a cure. In general, the more advanced the cancer ... However, treatment can often slow the progress of the cancer. What is stomach cancer..
Patient information leaflet
أسباب السرطان
Certain risk factors are known to increase the chance that one or more of your cells will become abnormal and lead to cancer. How does cancer start. The body is made up from millions of tiny cells. Different parts of the body such as organs, bones, muscles, skin and blood are made up from different specialised cells. Most cells have a centre.
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سرطان المريء
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Patient information leaflet
أنواع السرطان
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Patient information leaflet
سرطان الرئة
Lung cancer (cancer of the lung) is common worldwide. Around 4 in 10 cases develop in people over the age of 75 years, usually in smokers. If lung cancer is diagnosed at an early stage, there is a chance of a cure. Certai... See the separate leaflet called Causes of cancer for more details. Smoking Smoking is a major risk factor and is the main.
قراءة إضافية ومراجع
- Hereditary diffuse gastric cancer; MedlinePlus, National Library of Medicine.
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21 Mar 2023 | أحدث إصدار
1 Jan 2014 | نُشر في الأصل
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