core-binding factor subunit beta
آخر تحديث 18 Aug 2020
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ال CBFB gene provides instructions for making a protein called core binding factor beta (CBFβ), which is one piece of a protein complex known as core binding factor (CBF). CBFβ attaches (binds) to one of three related RUNX proteins (RUNX1, RUNX2, or RUNX3) to form different versions of CBF. These protein complexes bind to specific regions of DNA and help turn on (activate) certain genes.
Normal function
ال CBFB gene provides instructions for making a protein called core binding factor beta (CBFβ), which is one piece of a protein complex known as core binding factor (CBF). CBFβ attaches (binds) to one of three related RUNX proteins (RUNX1, RUNX2, or RUNX3) to form different versions of CBF. These protein complexes bind to specific regions of DNA and help turn on (activate) certain genes.
The presence of CBFβ helps the complex bind to DNA and protects the RUNX protein from being broken down. The function of CBF depends on which RUNX protein it includes. Once bound to DNA, the RUNX1 protein controls the activity of genes involved in the development of blood cells (hematopoiesis). The RUNX2 protein regulates genes important for bone cell development and formation of the skeleton. The RUNX3 protein primarily affects genes involved in the development of nerve cells.
Conditions referring to this gene or chromosome
Other names
CBF-beta
core-binding factor beta subunit
core-binding factor, beta subunit
PEA2-beta
PEBB_HUMAN
PEBP2-beta
PEBP2B
polyomavirus enhancer binding protein 2, beta subunit
polyomavirus enhancer-binding protein 2 beta subunit
SL3-3 enhancer factor 1 beta subunit
SL3-3 enhancer factor 1 subunit beta
SL3/AKV core-binding factor beta subunit
Related patient information and medicines
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هل يمكنني تناول أتورفاستاتين وبيسوبرولول معًا؟
These two medicines are very commonly prescribed together to manage heart health and blood pressure. Why this happens Atorvastatin is a statin used to lower cholesterol, and bisoprolol هو a beta-blocker used to manage blood pressure and heart rate. They are processed by different pathways in the body and do not interfere with how the other works..
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هل يمكنني تناول ألوغليبتين وبيسوبرولول معًا؟
It can also slightly increase the risk of your blood sugar dropping too low. Why this happens Bisoprolol is a beta-blocker. These medicines can mask the physical symptoms of low blood sugar, such as a fast heartbeat or tremors. Using other medicines Taking multiple ... Our Medicines Interaction Checker helps you check whether your prescriptions,.
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هل يمكنني تناول فطر عرف الأسد والماتشا معًا؟
In fact, man... However, because both substances can affect the brain and nervous system, some people may feel overly stimulated or experience a mild upset stomach. Why this happens Lion's Mane is thought to stimulate 'nerve growth factor' (NGF) to support brain health, while matcha contains caffeine and L-theanine which improve alertness and.
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هل يمكنني تناول بيسوبرولول وتريمبو معًا؟
Bisoprolol may cause the airways to narrow, making it harder to breathe and potentially triggering asthma or COPD symptoms. It also makes the formoterol in the Trimbow inhaler less effective at opening your airways. Why this happens Bisoprolol is a 'beta-blocker' and formoterol (in Trimbow) هو a 'beta-agonist'. They compete for the same receptors.
Patient information leaflet
هل يمكنني تناول أبيكسابان وبيسوبرولول معًا؟
They work in different ways and do not interfere with how the body pr... Why this happens Apixaban is an anticoagulant (blood thinner) that works by blocking a clotting factor called Factor Xa. Bisoprolol is a beta-blocker that slows the heart rate and lowers blood pressure. They are processed by different pathways in the liver and kidneys, and.
Patient information leaflet
هل يمكنني تناول رويال صن وشييتاكي معًا؟
Both Royal Sun (Agaricus blazei) and Shiitake (Lentinula edodes) mushrooms contain high levels من beta-glucans, which are substances that stimulate the immune system. Taking them together may cause your immune system to become overactive. Both mushrooms can lower blood sugar levels and thin the blood. Taking them together might increase the risk.
قراءة إضافية ومراجع
- core-binding factor subunit beta; MedlinePlus, National Library of Medicine.
- Eghtedar A, Borthakur G, Ravandi F, Jabbour E, Cortes J, Pierce S, Kantarjian H, Garcia-Manero G. Characteristics of translocation (16;16)(p13;q22) acute myeloid leukemia. Am J Hematol. 2012 Mar;87(3):317-8. doi: 10.1002/ajh.22258. Epub 2012 Jan 7.
- Goyama S, Mulloy JC. Molecular pathogenesis of core binding factor leukemia: current knowledge and future prospects. Int J Hematol. 2011 Aug;94(2):126-133. doi: 10.1007/s12185-011-0858-z. Epub 2011 May 3.
- Huang G, Shigesada K, Ito K, Wee HJ, Yokomizo T, Ito Y. Dimerization with PEBP2beta protects RUNX1/AML1 from ubiquitin-proteasome-mediated degradation. EMBO J. 2001 Feb 15;20(4):723-33. doi: 10.1093/emboj/20.4.723.
- Shigesada K, van de Sluis B, Liu PP. Mechanism of leukemogenesis by the inv(16) chimeric gene CBFB/PEBP2B-MHY11. Oncogene. 2004 May 24;23(24):4297-307. doi: 10.1038/sj.onc.1207748.
- Yoshida CA, Furuichi T, Fujita T, Fukuyama R, Kanatani N, Kobayashi S, Satake M, Takada K, Komori T. Core-binding factor beta interacts with Runx2 and is required for skeletal development. Nat Genet. 2002 Dec;32(4):633-8. doi: 10.1038/ng1015. Epub 2002 Nov 18.
تاريخ المقال
المقال متاح أيضًا باللغة الإنجليزية, الألمانية, إسبانية, الفرنسية, إيطالي, البرتغالية, الهندية, العبرية, العربية ,، و السويدية.
18 Aug 2020 | أحدث إصدار
1 Nov 2013 | نُشر في الأصل
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