cholinergic receptor nicotinic alpha 2 subunit
آخر تحديث 8 Aug 2025
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The CHRNA2 gene provides instructions for making one part (subunit) of a larger protein complex called a neuronal nicotinic acetylcholine receptor (nAChR). Each nAChR complex is made up of a combination of five subunits, usually two alpha (α) and three beta (β) subunits. Many different combinations are possible, and the characteristics of each nAChR complex depend on its specific subunits. The CHRNA2 gene is responsible for producing a subunit known as α2. Little is known about the specific function of nAChR proteins made with this subunit.
Normal function
The CHRNA2 gene provides instructions for making one part (subunit) of a larger protein complex called a neuronal nicotinic acetylcholine receptor (nAChR). Each nAChR complex is made up of a combination of five subunits, usually two alpha (α) and three beta (β) subunits. Many different combinations are possible, and the characteristics of each nAChR complex depend on its specific subunits. The CHRNA2 gene is responsible for producing a subunit known as α2. Little is known about the specific function of nAChR proteins made with this subunit.
In the brain, nAChR proteins are widely distributed and play an important role in chemical signaling between nerve cells (neurons). The nAChR acts as a channel, allowing charged atoms (ions), including calcium, sodium, and potassium, to cross the cell membrane. These channels open when they attach to a chemical messenger (neurotransmitter) called acetylcholine. The channels also open in response to nicotine, the addictive substance in tobacco.
Communication between neurons depends on neurotransmitters, which are released from one neuron and taken up by neighboring neurons. The release and uptake of these chemicals are tightly regulated to ensure that signals are passed efficiently and accurately between neurons. Researchers believe that nAChR channels play an important role in controlling the normal release and uptake of neurotransmitters.
A wide range of brain functions depend on nAChR channels, including sleep and arousal, fatigue, anxiety, attention, pain perception, and memory. The channels are also active before birth, which suggests that they are involved in early brain development.
Conditions referring to this gene or chromosome
Other names
Acetylcholine receptor, neuronal nicotonic, alpha-2 subunit
ACHA2_HUMAN
Cholinergic receptor, neuronal nicotinic, alpha polypeptide 2
cholinergic receptor, nicotinic alpha 2
cholinergic receptor, nicotinic, alpha 2
cholinergic receptor, nicotinic, alpha 2 (neuronal)
cholinergic receptor, nicotinic, alpha polypeptide 2 (neuronal)
Related patient information and medicines
Patient information leaflet
داء الخلايا البدينة واضطرابات الخلايا البدينة
Digestive symptoms H 2 -receptor antagonists or ... Oral sodium cromoglicate is beneficial in people with diarrhoea and tummy (abdominal) pain. Anticholinergic medication such as propantheline (which blocks the effects of a body chemical called acetylcholine) may help control diarrhoea. Other treatments Medicines called leukotriene inhibitors used.
Patient information leaflet
السكري من النوع 2
Treatment aim 2 - to... Even mildly raised blood pressure should be treated if you have type 2 diabetes. As well as expert help and advice, medication or nicotine replacement therapy (nicotine gum, etc) may help you to stop. This will help to lower the risk of developing some complications such as heart disease , peripheral arterial disease and.
Patient information leaflet
هل يمكنني تناول شاجا وكورديسيبس معًا؟
Caffeine Cordyceps may have mild stimulant properties and can interact مع adenosine receptors. Combining it with caffeine (coffee, tea, energy drinks) may increase heart rate, jitteriness, or palpitations in sensitive individuals. Using other الأدوية Taking multiple medicines. لدينا مدقق تفاعلات الأدوية helps you check whether your.
Patient information leaflet
موسعات الأوعية المحيطية
موسعات الأوعية المحيطية are medicines that are used to treat conditions that affect blood vessels in outer (peripheral) parts of the body such as the arms and legs. For example, they are used to treat peripheral arterial disease and Raynaud's phenomenon. They ease the symptoms of these conditions by dilating the blood vessels, preventing them from.
Patient information leaflet
هل يمكنني تناول بيريدوستيغمين وراميبريل معًا؟
It can cause serious harm to an unborn baby, particularly affecting their kidney development... Use effective contraception while taking this medicine. Cholinergic Crisis (Overdose) - pyridostigmine If you experience severe muscle weakness, abdominal cramps, or difficulty breathing, seek urgent medical help. These can be signs of an overdose,.
Patient information leaflet
الثلاسيميا
There are different types, which vary from a mild condition to a serious or life-threatening condition. For the more severe forms of thalassaemia, modern treatment gives a good outlook, but lifelong monitoring and treatment are needed. Good treatment is important to prevent complications developing. Haemoglobin is made out of different parts. The.
قراءة إضافية ومراجع
- cholinergic receptor nicotinic alpha 2 subunit; MedlinePlus, National Library of Medicine.
- Aridon P, Marini C, Di Resta C, Brilli E, De Fusco M, Politi F, Parrini E, Manfredi I, Pisano T, Pruna D, Curia G, Cianchetti C, Pasqualetti M, Becchetti A, Guerrini R, Casari G. Increased sensitivity of the neuronal nicotinic receptor alpha 2 subunit causes familial epilepsy with nocturnal wandering and ictal fear. Am J Hum Genet. 2006 Aug;79(2):342-50. doi: 10.1086/506459. Epub 2006 Jun 26.
- Arneric SP, Holladay M, Williams M. Neuronal nicotinic receptors: a perspective on two decades of drug discovery research. Biochem Pharmacol. 2007 Oct 15;74(8):1092-101. doi: 10.1016/j.bcp.2007.06.033. Epub 2007 Jun 26.
- Combi R, Ferini-Strambi L, Tenchini ML. CHRNA2 mutations are rare in the NFLE population: evaluation of a large cohort of Italian patients. Sleep Med. 2009 Jan;10(1):139-42. doi: 10.1016/j.sleep.2007.11.010. Epub 2008 Jan 28.
- Gu W, Bertrand D, Steinlein OK. A major role of the nicotinic acetylcholine receptor gene CHRNA2 in autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE) is unlikely. Neurosci Lett. 2007 Jul 5;422(1):74-6. doi: 10.1016/j.neulet.2007.06.006. Epub 2007 Jun 8.
- Marini C, Guerrini R. The role of the nicotinic acetylcholine receptors in sleep-related epilepsy. Biochem Pharmacol. 2007 Oct 15;74(8):1308-14. doi: 10.1016/j.bcp.2007.06.030. Epub 2007 Jun 23.
تاريخ المقال
المقال متاح أيضًا باللغة الإنجليزية, الألمانية, إسبانية, الفرنسية, إيطالي, البرتغالية, الهندية, العبرية, العربية ,، و السويدية.
8 Aug 2025 | أحدث إصدار
1 Apr 2009 | نُشر في الأصل
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