chloride voltage-gated channel Ka
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ال CLCNKA gene belongs to the CLC family of genes, which provide instructions for making chloride channels. These channels, which transport negatively charged chlorine atoms (chloride ions), play a key role in a cell's ability to generate and transmit electrical signals. Some CLC channels regulate the flow of chloride ions across cell membranes, while others transport chloride ions within cells.
Normal function
ال CLCNKA gene belongs to the CLC family of genes, which provide instructions for making chloride channels. These channels, which transport negatively charged chlorine atoms (chloride ions), play a key role in a cell's ability to generate and transmit electrical signals. Some CLC channels regulate the flow of chloride ions across cell membranes, while others transport chloride ions within cells.
ال CLCNKA gene provides instructions for making a chloride channel called ClC-Ka. These channels are found predominantly in the kidneys. ClC-Ka is one of several proteins that work together to regulate the movement of ions into and out of kidney cells. The transport of chloride ions by ClC-Ka channels is part of the mechanism by which the kidneys reabsorb salt (sodium chloride or NaCl) from the urine back into the bloodstream. The retention of salt affects the body's fluid levels and helps maintain blood pressure.
ClC-Ka channels are also located in the inner ear, where they play a role in normal hearing.
Conditions referring to this gene or chromosome
Other names
chloride channel Ka
chloride channel protein ClC-Ka
chloride channel, kidney, A
chloride channel, voltage-sensitive Ka
ClC-K1
CLCK1
CLCKA_HUMAN
hClC-Ka
Related patient information and medicines
Patient information leaflet
هل يمكنني تناول أتورفاستاتين وكانديسارتان معًا؟
Salt substitutes (potassium-based) Candesartan can increase the levels of potassium in your blood. Many 'low-sodium' salt substitutes contain potassium chloride. استخدام these while taking candesartan can lead to dangerously high potassium levels (hyperkalaemia). Check with your pharmacist before using salt substitutes. Using other medicines Taking.
Patient information leaflet
تورم الغدد الليمفاوية
تورم الغدد الليمفاوية (also called lymph nodes) are usually a sign that your body is fighting infection, but they can have other causes. Common areas for swollen glands include the neck, under the chin, in the armpits and in the groin. Swollen lymph glands caused by infection usually get better on their own within two weeks. In this leaflet we.
Patient information leaflet
هل يمكنني تناول ليسينوبريل والبوتاسيوم معًا؟
Stomach or intestinal blockages Potassium tablets can cause severe irritation or ulcers in the digestive tract; they must be taken with a ... Food and drink warnings Salt substitutes and low-sodium salts (e.g., LoSalt) These products often contain potassium chloride. Taking them alongside lisinopril or potassium supplements can cause your blood.
Patient information leaflet
اختبار دم روتيني لوظائف الكلى
When doctors talk about a blood test for the kidneys, they usually mean a single blood test that measures the following four things: Urea. Creatinine. Sodium. Potassium. Some laboratories also measure chloride and bicarbonate routinely, whereas in other labs these are only done if the clinician specifically asks for them. These blood tests are.
Patient information leaflet
التليف الكيسي
التليف الكيسي هو an inherited disease which mainly affects the lungs and pancreas but can involve other organs. Symptoms usually begin in early childhood and include persistent cough, wheeze, repeated chest infections, difficulty digesting food and general ill health. Treatments include antibiotics, physiotherapy, medicines for thinning mucus,.
Patient information leaflet
أقدام متعرقة
It may lead to smelly feet, and nobody likes stinky feet. This leaflet explains why feet sweat (which is normal) and how to stop your feet from being sweaty or smelly. Why do feet sweat. Sweating is normal. It has three main functions: Heat regulation - sweating cools the body by wetting the surface of the skin. Excretion - another way for the.
قراءة إضافية ومراجع
- chloride voltage-gated channel Ka; MedlinePlus, National Library of Medicine.
- Barlassina C, Dal Fiume C, Lanzani C, Manunta P, Guffanti G, Ruello A, Bianchi G, Del Vecchio L, Macciardi F, Cusi D. Common genetic variants and haplotypes in renal CLCNKA gene are associated to salt-sensitive hypertension. Hum Mol Genet. 2007 Jul 1;16(13):1630-8. doi: 10.1093/hmg/ddm112. Epub 2007 May 17.
- Kieferle S, Fong P, Bens M, Vandewalle A, Jentsch TJ. Two highly homologous members of the ClC chloride channel family in both rat and human kidney. Proc Natl Acad Sci U S A. 1994 Jul 19;91(15):6943-7. doi: 10.1073/pnas.91.15.6943.
- Kramer BK, Bergler T, Stoelcker B, Waldegger S. Mechanisms of Disease: the kidney-specific chloride channels ClCKA and ClCKB, the Barttin subunit, and their clinical relevance. Nat Clin Pract Nephrol. 2008 Jan;4(1):38-46. doi: 10.1038/ncpneph0689.
- Nozu K, Inagaki T, Fu XJ, Nozu Y, Kaito H, Kanda K, Sekine T, Igarashi T, Nakanishi K, Yoshikawa N, Iijima K, Matsuo M. Molecular analysis of digenic inheritance in Bartter syndrome with sensorineural deafness. J Med Genet. 2008 Mar;45(3):182-6. doi: 10.1136/jmg.2007.052944.
- Schlingmann KP, Konrad M, Jeck N, Waldegger P, Reinalter SC, Holder M, Seyberth HW, Waldegger S. Salt wasting and deafness resulting from mutations in two chloride channels. N Engl J Med. 2004 Mar 25;350(13):1314-9. doi: 10.1056/NEJMoa032843. No abstract available.
تاريخ المقال
المقال متاح أيضًا باللغة الإنجليزية, الألمانية, إسبانية, الفرنسية, إيطالي, البرتغالية, الهندية, العبرية, العربية ,، و السويدية.
20 مارس 2023 | أحدث إصدار
1 Feb 2011 | نُشر في الأصل
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