glutamate ionotropic receptor NMDA type subunit 2B
آخر تحديث 18 Aug 2020
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ال GRIN2B gene provides instructions for making a protein called GluN2B. This protein is found in nerve cells (neurons) in the brain, primarily during development before birth. The GluN2B protein is one component (subunit) of a subset of specialized protein structures called NMDA receptors. There are several types of NMDA receptors, made up of different combinations of proteins.
Normal function
ال GRIN2B gene provides instructions for making a protein called GluN2B. This protein is found in nerve cells (neurons) in the brain, primarily during development before birth. The GluN2B protein is one component (subunit) of a subset of specialized protein structures called NMDA receptors. There are several types of NMDA receptors, made up of different combinations of proteins.
NMDA receptors are glutamate-gated ion channels. When brain chemicals called glutamate and glycine attach to the receptor, a channel opens, allowing positively charged particles (cations) to flow through. The flow of cations activates (excites) neurons to send signals to each other. The cation flow also plays a role in the process by which the neurons mature to carry out specific functions (differentiation). NMDA receptors are involved in normal brain development, changes in the brain in response to experience (synaptic plasticity), learning, and memory.
Conditions referring to this gene or chromosome
Other names
GluN2B
glutamate [NMDA] receptor subunit epsilon-2
glutamate receptor ionotropic, NMDA 2B precursor
glutamate receptor subunit epsilon-2
glutamate receptor, ionotropic, N-methyl D-aspartate 2B
hNR3
N-methyl D-aspartate receptor subtype 2B
NMDAR2B
NR2B
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قراءة إضافية ومراجع
- glutamate ionotropic receptor NMDA type subunit 2B; MedlinePlus, National Library of Medicine.
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المقال متاح أيضًا باللغة الإنجليزية, الألمانية, إسبانية, الفرنسية, إيطالي, البرتغالية, الهندية, العبرية, العربية ,، و السويدية.
18 Aug 2020 | أحدث إصدار
1 Sept 2018 | نُشر في الأصل
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