potassium voltage-gated channel subfamily A member 1
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The KCNA1 gene belongs to a large family of genes that provide instructions for making potassium channels. These channels, which transport positively charged potassium atoms (potassium ions) into and out of cells, play a key role in a cell's ability to generate and transmit electrical signals.
Normal function
The KCNA1 gene belongs to a large family of genes that provide instructions for making potassium channels. These channels, which transport positively charged potassium atoms (potassium ions) into and out of cells, play a key role in a cell's ability to generate and transmit electrical signals.
The KCNA1 gene provides instructions for making one part (the alpha subunit) of a potassium channel called Kv1.1. These channels are found in the brain, where they transport potassium ions into nerve cells (neurons). The flow of certain ions, including potassium, into and out of neurons regulates communication between these cells.
Conditions referring to this gene or chromosome
Other names
AEMK
EA1
HBK1
HUK1
KCNA1_HUMAN
KV1.1
MBK1
MGC126782
MGC138385
MK1
potassium channel, voltage gated shaker related subfamily A, member 1
potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia)
RBK1
voltage-gated potassium channel subunit Kv1.1
Related patient information and medicines
Patient information leaflet
إصابة الكلى الحادة
إصابة الكلى الحادة can be a confusing name as it suggests an accident or injury to that part of your body, eg from a fall or trauma. However, acute kidney injury is actually a condition where your kidneys suddenly stop working properly. The earlier acute kidney injury is picked up, and the more carefully you are monitored and treated, the better.
Patient information leaflet
هل يمكنني تناول بيسوبرولول وراميبريل معًا؟
Food and drink warnings Alcohol Alcohol can increase the blood pressure-lowering effect of bisoprolol, which m... It is best to keep your alcohol intake within recommended limits and see how the medicine affects you before drinking. Salt substitutes (Potassium-based) Ramipril can increase the levels of potassium in your blood. Many salt.
Patient information leaflet
هل يمكنني تناول أتينولول وراميبريل معًا؟
Ou... Simply search for your medicines to see potential interactions and what to do about them. إخلاء المسؤولية This information is لـ general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions.
Patient information leaflet
هل يمكنني تناول كو-أموكسكلاف وراميبريل معًا؟
Taking co-amoxiclav and ramipril together can occasionally increase the risk of a rare but serious allergic reaction called angioedema (swelling under the skin). It may also increase the risk of high potassium levels in the blood or affect your kidney function, especially if you are already unwell with an infection. Why this happens Both drugs can.
Patient information leaflet
هل يمكنني تناول نوستيندي وراميبريل معًا؟
Taking Nustendi and ramipril together يمكن أن increase the risk of your الكلى not working as well as they should. It may also lead to high levels of potassium in your blood (hyperkalaemia). Why this happens Nustendi contains two medicines: bempedoic acid and ezetimibe. Bempedoic acid can sometimes increase levels of uric acid and affect kidney.
Patient information leaflet
هل يمكنني تناول إبليرينون والباراسيتامول معًا؟
Additionally, alcohol can lower your blood pressure, which may add to the blood-pressure-lowe... Why this happens Eplerenone and paracetamol are processed by different pathways in the body. Eplerenone is a diuretic (water tablet) that works on the kidneys to help with heart conditions, while paracetamol is a painkiller processed mainly by the.
قراءة إضافية ومراجع
- potassium voltage-gated channel subfamily A member 1; MedlinePlus, National Library of Medicine.
- Browne DL, Gancher ST, Nutt JG, Brunt ER, Smith EA, Kramer P, Litt M. Episodic ataxia/myokymia syndrome is associated with point mutations in the human potassium channel gene, KCNA1. Nat Genet. 1994 Oct;8(2):136-40. doi: 10.1038/ng1094-136.
- Chen H, von Hehn C, Kaczmarek LK, Ment LR, Pober BR, Hisama FM. Functional analysis of a novel potassium channel (KCNA1) mutation in hereditary myokymia. Neurogenetics. 2007 Apr;8(2):131-5. doi: 10.1007/s10048-006-0071-z. Epub 2006 Nov 29.
- Eunson LH, Rea R, Zuberi SM, Youroukos S, Panayiotopoulos CP, Liguori R, Avoni P, McWilliam RC, Stephenson JB, Hanna MG, Kullmann DM, Spauschus A. Clinical, genetic, and expression studies of mutations in the potassium channel gene KCNA1 reveal new phenotypic variability. Ann Neurol. 2000 Oct;48(4):647-56.
- Jen JC, Graves TD, Hess EJ, Hanna MG, Griggs RC, Baloh RW; CINCH investigators. Primary episodic ataxias: diagnosis, pathogenesis and treatment. Brain. 2007 Oct;130(Pt 10):2484-93. doi: 10.1093/brain/awm126. Epub 2007 Jun 15.
- Maylie B, Bissonnette E, Virk M, Adelman JP, Maylie JG. Episodic ataxia type 1 mutations in the human Kv1.1 potassium channel alter hKvbeta 1-induced N-type inactivation. J Neurosci. 2002 Jun 15;22(12):4786-93. doi: 10.1523/JNEUROSCI.22-12-04786.2002.
- Rajakulendran S, Schorge S, Kullmann DM, Hanna MG. Episodic ataxia type 1: a neuronal potassium channelopathy. Neurotherapeutics. 2007 Apr;4(2):258-66. doi: 10.1016/j.nurt.2007.01.010.
- Rea R, Spauschus A, Eunson LH, Hanna MG, Kullmann DM. Variable K(+) channel subunit dysfunction in inherited mutations of KCNA1. J Physiol. 2002 Jan 1;538(Pt 1):5-23. doi: 10.1113/jphysiol.2001.013242.
- Zerr P, Adelman JP, Maylie J. Episodic ataxia mutations in Kv1.1 alter potassium channel function by dominant negative effects or haploinsufficiency. J Neurosci. 1998 Apr 15;18(8):2842-8. doi: 10.1523/JNEUROSCI.18-08-02842.1998.
تاريخ المقال
المقال متاح أيضًا باللغة الإنجليزية, الألمانية, إسبانية, الفرنسية, إيطالي, البرتغالية, الهندية, العبرية, العربية ,، و السويدية.
4 مايو 2023 | أحدث إصدار
1 May 2023 | نُشر في الأصل
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