lysine demethylase 6A

Normal function

ال KDM6A gene provides instructions for making an enzyme called lysine-specific demethylase 6A that is found in many organs and tissues of the body. Lysine-specific demethylase 6A functions as a histone demethylase. Histone demethylases are enzymes that modify proteins called histones. Histones are structural proteins that attach (bind) to DNA and give chromosomes their shape. By removing a molecule called a methyl group from histones (a process called demethylation), histone demethylases control (regulate) the activity of certain genes. Lysine-specific demethylase 6A appears to regulate certain genes that are important for development.

Lysine-specific demethylase 6A is also believed to act as a tumour suppressor, which means it normally helps prevent cells from growing and dividing in an uncontrolled way.

Conditions referring to this gene or chromosome

• سرطان المثانة

• Kabuki syndrome

Other names

bA386N14.2

bA386N14.2 (ubiquitously transcribed X chromosome tetratricopeptide repeat protein (UTX))

histone demethylase UTX

KABUK2

KDM6A_HUMAN

lysine (K)-specific demethylase 6A

lysine-specific demethylase 6A

ubiquitously transcribed tetratricopeptide repeat protein X-linked

ubiquitously-transcribed TPR gene on the X chromosome

ubiquitously-transcribed TPR protein on the X chromosome

UTX