killin, p53 regulated DNA replication inhibitor
آخر تحديث 2 Feb 2021
يتوافق مع الإرشادات التحريرية
- تنزيلتنزيل
- مشاركة
- Language
- نقاش
- نسخة صوتية
- أضف إلى المصادر المفضلة على جوجل
The KLLN gene provides instructions for making a protein called killin. The activity of the KLLN gene is controlled by a protein called p53 (which is produced from the TP53 gene). Little is known about the function of killin, although it is thought to trigger cells to self-destruct (undergo apoptosis) when they are damaged or no longer needed. In this way, killin helps to prevent abnormal cells from growing and dividing unchecked to form tumours. Through its role in regulating cell division, killin helps maintain the stability of a cell's genetic information. Based on these roles, killin is thought to be a tumour suppressor.
Normal function
The KLLN gene provides instructions for making a protein called killin. The activity of the KLLN gene is controlled by a protein called p53 (which is produced from the TP53 gene). Little is known about the function of killin, although it is thought to trigger cells to self-destruct (undergo apoptosis) when they are damaged or no longer needed. In this way, killin helps to prevent abnormal cells from growing and dividing unchecked to form tumours. Through its role in regulating cell division, killin helps maintain the stability of a cell's genetic information. Based on these roles, killin is thought to be a tumour suppressor.
Conditions referring to this gene or chromosome
Other names
KILIN_HUMAN
KILLIN
killin
killin, p53-regulated DNA replication inhibitor
Related patient information and medicines
Patient information leaflet
ابيضاض الدم النقوي المزمن
Chronic myeloid leukaemia (CML) is sometimes called chronic myelogenous leukaemia, chronic granulocytic leukaemia, or chronic myelocytic leukaemia. What is chronic myeloid leukaemia. Chronic myeloid leukaemia (CML) is sometimes called chronic myelogenous leukaemia, chronic granulocytic leukaemia, or chronic myelocytic leukaemia. CML develops due.
Patient information leaflet
سرطان الكلى
The mos... If kidney cancer is diagnosed at an early stage, there is a good chance of a cure. A description of what kidneys are and how they work is at the bottom of this article. This is sometimes called renal adenocarcinoma or renal cell carcinoma or hypernephroma. Renal cell cancer This type of cancer develops from a cell in a kidney tubule,.
Patient information leaflet
مرض باركنسون
The main symptoms of Parkinson's disease are usually stiffness, shaking (tremor), و slowness of movement. Parkinson's disease symptoms The brain cells and nerves affected in Parkinson's disease (PD) normally help to produce smooth, co-ordinated movements of muscles. When this system goes wrong, movement disorders (motor symptoms) occur. Three.
Patient information leaflet
الفحص الجيني
الفحص الجيني is a type of medical test that identifies changes in chromosomes, genes or proteins. Genetic tests examine a person's DNA in a variety of ways to assess a person's genetic health. Chromosomes are made from DNA (deoxyribonucleic acid). Genes are short sections of DNA and each chromosome contains hundreds to thousands of genes. The.
Patient information leaflet
Medical negligence
يوجد a separate Health Service Ombudsman for England, Scotland, Wales and Northern Ireland. (In Northern Ireland, pharmacists يكون regulated by the Pharmaceutical Society of Northern Ireland). The Health and Care Professions Council (HCPC), for art therapists, biomedical scientists, chiropodists and podiatrists, clinical scientists, dieticians,.
Patient information leaflet
مرض الكلى السكري
Also, it aims to reduce the risk of developing أمراض القلب والأوعية الدموية such as heart attack and stroke which are much more common than average in people with this disease. To find out more about the kidneys and urine, see the leaflet called What do kidneys do. Diabetic kidney disease is one of the causes of chronic kidney disease , a long-term.
قراءة إضافية ومراجع
- killin, p53 regulated DNA replication inhibitor; MedlinePlus, National Library of Medicine.
- Bennett KL, Mester J, Eng C. Germline epigenetic regulation of KILLIN in Cowden and Cowden-like syndrome. JAMA. 2010 Dec 22;304(24):2724-31. doi: 10.1001/jama.2010.1877.
- Jelovac D, Park BH. PTEN promoter silencing and Cowden syndrome: the role of epigenetic regulation of KILLIN. JAMA. 2010 Dec 22;304(24):2744-5. doi: 10.1001/jama.2010.1863. No abstract available.
- Nizialek EA, Sankunny M, Niazi F, Eng C. Cancer-predisposition gene KLLN maintains pericentric H3K9 trimethylation protecting genomic stability. Nucleic Acids Res. 2016 May 5;44(8):3586-94. doi: 10.1093/nar/gkv1481. Epub 2015 Dec 15.
- Sankunny M, Eng C. Identification of nuclear export signal in KLLN suggests potential role in proteasomal degradation in cancer cells. Oncotarget. 2020 Dec 15;11(50):4625-4636. doi: 10.18632/oncotarget.27833. eCollection 2020 Dec 15.
- Sankunny M, Eng C. KLLN-mediated DNA damage-induced apoptosis is associated with regulation of p53 phosphorylation and acetylation in breast cancer cells. Cell Death Discov. 2018 Sep 11;4:31. doi: 10.1038/s41420-018-0094-x. eCollection 2018.
تاريخ المقال
المقال متاح أيضًا باللغة الإنجليزية, الألمانية, إسبانية, الفرنسية, إيطالي, البرتغالية, الهندية, العبرية, العربية ,، و السويدية.
2 Feb 2021 | أحدث إصدار
1 Sept 2012 | نُشر في الأصل
انضم إلى المحادثة
شارك أفكارك أو تجاربك مع الآخرين في مجتمعات المرضى.
اسأل، شارك، تواصل.
تصفح المناقشات، اطرح الأسئلة، وشارك التجارب عبر مئات المواضيع الصحية.
اشترك في النشرة الإخبارية للمرضى
جرعتك الأسبوعية من النصائح الصحية الواضحة والموثوقة - مكتوبة لمساعدتك على الشعور بالاطلاع والثقة والتحكم.
من خلال الاشتراك، فإنك تقبل سياسة الخصوصية. يمكنك إلغاء الاشتراك في أي وقت. نحن لا نبيع بياناتك أبدًا.