PNKD metallo-beta-lactamase domain containing
آخر تحديث 28 Jun 2022
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Researchers have not determined the role of the PNKD gene (frequently called the MR1 gene) in the human body. This gene is highly active (expressed) in the brain, which suggests that it plays an important role in normal brain function. The protein produced from the PNKD gene may help control the release of chemicals called neurotransmitters, which allow nerve cells (neurons) to communicate with one another.
Normal function
Researchers have not determined the role of the PNKD gene (frequently called the MR1 gene) in the human body. This gene is highly active (expressed) in the brain, which suggests that it plays an important role in normal brain function. The protein produced from the PNKD gene may help control the release of chemicals called neurotransmitters, which allow nerve cells (neurons) to communicate with one another.
The PNKD protein is similar to another protein that helps break down a chemical called methylglyoxal. Methylglyoxal is found in alcoholic beverages, coffee, tea, and cola. Research has demonstrated that this chemical is toxic to nerve cells (neurons). The PNKD protein may perform a function similar to this protein.
Conditions referring to this gene or chromosome
Other names
brain protein 17
BRP17
DKFZp564N1362
DYT8
FKSG19
FPD1
KIAA1184
KIPP1184
MGC31943
MR-1
MR-1S
MR1
myofibrillogenesis regulator 1
paroxysmal nonkinesigenic dyskinesia
PDC
PKND1
PNKD_HUMAN
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This leaflet gives a brief overview of the different types of germs (microbes) that can cause infections. What are germs. Another example is some bacteria produce chemicals called enzymes مثل extended-spectrum beta-lactamases (ESBLs) , which make them resistant to some antibiotics. The more antibiotics are used, the greater the problem of.
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هل يمكنني تناول ريشي وذيل الديك الرومي معًا؟
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هل يمكنني تناول الريشي والشمس الملكية معًا؟
كلاهما Reishi and Royal Sun (Agaricus blazei) mushrooms can thin the blood and lower blood sugar levels. Consuming high amounts of caffeine may counteract the intende... General Food Intake These medicinal mushrooms contain complex polysaccharides (beta-glucans). For the best absorption, it is often recommended to take them on an empty stomach, at.
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هل يمكنني تناول رويال صن ووايت بوتون معًا؟
كلاهما Royal Sun (Agaricus blazei) و White Button mushrooms contain compounds that may lower blood sugar levels. Taking them together could potentially cause your blood sugar to drop too low (hypoglycaemia). General Food Intake These medicinal mushrooms contain complex polysaccharides (beta-glucans). لدينا مدقق تفاعلات الأدوية helps you.
قراءة إضافية ومراجع
- PNKD metallo-beta-lactamase domain containing; MedlinePlus, National Library of Medicine.
- Bruno MK, Lee HY, Auburger GW, Friedman A, Nielsen JE, Lang AE, Bertini E, Van Bogaert P, Averyanov Y, Hallett M, Gwinn-Hardy K, Sorenson B, Pandolfo M, Kwiecinski H, Servidei S, Fu YH, Ptacek L. Genotype-phenotype correlation of paroxysmal nonkinesigenic dyskinesia. Neurology. 2007 May 22;68(21):1782-9. doi: 10.1212/01.wnl.0000262029.91552.e0.
- Chen DH, Matsushita M, Rainier S, Meaney B, Tisch L, Feleke A, Wolff J, Lipe H, Fink J, Bird TD, Raskind WH. Presence of alanine-to-valine substitutions in myofibrillogenesis regulator 1 in paroxysmal nonkinesigenic dyskinesia: confirmation in 2 kindreds. Arch Neurol. 2005 Apr;62(4):597-600. doi: 10.1001/archneur.62.4.597.
- Gardiner AR, Jaffer F, Dale RC, Labrum R, Erro R, Meyer E, Xiromerisiou G, Stamelou M, Walker M, Kullmann D, Warner T, Jarman P, Hanna M, Kurian MA, Bhatia KP, Houlden H. The clinical and genetic heterogeneity of paroxysmal dyskinesias. Brain. 2015 Dec;138(Pt 12):3567-80. doi: 10.1093/brain/awv310. Epub 2015 Nov 23.
- Lee HY, Xu Y, Huang Y, Ahn AH, Auburger GW, Pandolfo M, Kwiecinski H, Grimes DA, Lang AE, Nielsen JE, Averyanov Y, Servidei S, Friedman A, Van Bogaert P, Abramowicz MJ, Bruno MK, Sorensen BF, Tang L, Fu YH, Ptacek LJ. The gene for paroxysmal non-kinesigenic dyskinesia encodes an enzyme in a stress response pathway. Hum Mol Genet. 2004 Dec 15;13(24):3161-70. doi: 10.1093/hmg/ddh330. Epub 2004 Oct 20.
- Rainier S, Thomas D, Tokarz D, Ming L, Bui M, Plein E, Zhao X, Lemons R, Albin R, Delaney C, Alvarado D, Fink JK. Myofibrillogenesis regulator 1 gene mutations cause paroxysmal dystonic choreoathetosis. Arch Neurol. 2004 Jul;61(7):1025-9. doi: 10.1001/archneur.61.7.1025.
- Shen Y, Ge WP, Li Y, Hirano A, Lee HY, Rohlmann A, Missler M, Tsien RW, Jan LY, Fu YH, Ptacek LJ. Protein mutated in paroxysmal dyskinesia interacts with the active zone protein RIM and suppresses synaptic vesicle exocytosis. Proc Natl Acad Sci U S A. 2015 Mar 10;112(10):2935-41. doi: 10.1073/pnas.1501364112. Epub 2015 Feb 17.
- Shen Y, Lee HY, Rawson J, Ojha S, Babbitt P, Fu YH, Ptacek LJ. Mutations in PNKD causing paroxysmal dyskinesia alters protein cleavage and stability. Hum Mol Genet. 2011 Jun 15;20(12):2322-32. doi: 10.1093/hmg/ddr125. Epub 2011 Apr 12.
تاريخ المقال
المقال متاح أيضًا باللغة الإنجليزية, الألمانية, إسبانية, الفرنسية, إيطالي, البرتغالية, الهندية, العبرية, العربية ,، و السويدية.
28 Jun 2022 | أحدث إصدار
1 أغسطس 2017 | نُشر في الأصل
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