thyroid peroxidase
آخر تحديث 18 Aug 2020
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ال TPO gene provides instructions for making an enzyme called thyroid peroxidase. This enzyme plays a central role in the function of the thyroid gland, a butterfly-shaped tissue in the lower neck. Thyroid peroxidase assists the chemical reaction that adds iodine to a protein called thyroglobulin, a critical step in generating thyroid hormones. Thyroid hormones play an important role in regulating growth, brain development, and the rate of chemical reactions in the body (metabolism).
Normal function
ال TPO gene provides instructions for making an enzyme called thyroid peroxidase. This enzyme plays a central role in the function of the thyroid gland, a butterfly-shaped tissue in the lower neck. Thyroid peroxidase assists the chemical reaction that adds iodine to a protein called thyroglobulin, a critical step in generating thyroid hormones. Thyroid hormones play an important role in regulating growth, brain development, and the rate of chemical reactions in the body (metabolism).
To function properly, thyroid peroxidase must be located in the cell membrane of certain thyroid cells, called follicular cells. Thyroid peroxidase has several different versions (isoforms), which vary by size and location within the cell. Some versions do not function because they are not located in the cell membrane.
Conditions referring to this gene or chromosome
Other names
MSA
PERT_HUMAN
thyroid microsomal antigen
thyroperoxidase
TPX
Related patient information and medicines
Patient information leaflet
هل يمكنني تناول الأشواغاندا وفيتامين سي معًا؟
Ashwagandha is an adaptogenic herb that works primarily on the body's stress response system (the adrenal glands), while vitamin C... Autoimmune diseases Ashwagandha can stimulate the immune system, which may worsen the symptoms of autoimmune conditions such as lupus, rheumatoid arthritis, and MS. Hyperthyroidism (overactive thyroid) Ashwagandha.
Patient information leaflet
اضطرابات الغدة النخامية
Take the example of the control من thyroid hormones from the thyroid gland in the neck. ...mulating hormone (TSH) Thyroid gland TSH stimulates the الغدة الدرقية to produce its own hormones, triiodothyronine (T3) و thyroxineFurther more detailed information available free online The Hypophysis Cerebri From Gray's Anatomy Online Human.
Patient information leaflet
هل يمكنني تناول البيوتين والكولاجين معًا؟
However, be aware that high doses من البيوتين يمكن أن interfere with certain medical blood tests (مثل thyroid or heart enzyme tests). Important precautions Blood test interference Biotin can significantly interfere with laboratory blood tests, بما في ذلك thyroid function and heart attack markers (troponin), leading to dangerously incorrect results..
Patient information leaflet
هل يمكنني تناول المورينجا والبروجينوفا معًا؟
If you are taking medication for diabetes, using moringa may cause your blood sugar to drop too low (hypoglycaemia). Hypothyroidism (Underactive thyroid) Moringa may interfere with thyroid function و reduce the effectiveness of thyroid hormone replacement medications أعجبني levothyroxine. Food and drink warnings Alcohol It is best to avoid or.
Patient information leaflet
هل يمكنني تناول الأشواغاندا والمغنيسيوم معًا؟
Important precautions Autoimmune diseases أشواغاندا can stimulate the immune system, which may worsen symptoms of autoimmune conditions or interfere with immunosuppressant medications Thyroid disorders (hyperthyroidism) Ashwagandha مايو increase thyroid hormone levels; this can be dangerous for people with overactive thyroids or those taking.
Patient information leaflet
هل يمكنني تناول كاربيميزول والكولاجين معًا؟
There is no known interaction between carbimazole and collagen supplements. Carbimazole هو a medication used to treat an overactive thyroid, while collagen is a protein supplement often taken for skin, joint, or hair health. They do not interfere with how each other works in the body. Why this happens Carbimazole is processed by the liver and.
قراءة إضافية ومراجع
- thyroid peroxidase; MedlinePlus, National Library of Medicine.
- Bakker B, Bikker H, Vulsma T, de Randamie JS, Wiedijk BM, De Vijlder JJ. Two decades of screening for congenital hypothyroidism in The Netherlands: TPO gene mutations in total iodide organification defects (an update). J Clin Endocrinol Metab. 2000 Oct;85(10):3708-12. doi: 10.1210/jcem.85.10.6878.
- Cangul H, Aycan Z, Olivera-Nappa A, Saglam H, Schoenmakers NA, Boelaert K, Cetinkaya S, Tarim O, Bober E, Darendeliler F, Bas V, Demir K, Aydin BK, Kendall M, Cole T, Hogler W, Chatterjee VK, Barrett TG, Maher ER. Thyroid dyshormonogenesis is mainly caused by TPO mutations in consanguineous community. Clin Endocrinol (Oxf). 2013 Aug;79(2):275-81. doi: 10.1111/cen.12127. Epub 2013 May 6.
- Chardes T, Chapal N, Bresson D, Bes C, Giudicelli V, Lefranc MP, Peraldi-Roux S. The human anti-thyroid peroxidase autoantibody repertoire in Graves' and Hashimoto's autoimmune thyroid diseases. Immunogenetics. 2002 Jun;54(3):141-57. doi: 10.1007/s00251-002-0453-9. Epub 2002 May 3.
- Kotani T, Umeki K, Kawano J, Suganuma T, Hishinuma A, Ieiri T, Harada S. Partial iodide organification defect caused by a novel mutation of the thyroid peroxidase gene in three siblings. Clin Endocrinol (Oxf). 2003 Aug;59(2):198-206. doi: 10.1046/j.1365-2265.2003.01823.x.
- Lee CC, Harun F, Jalaludin MY, Lim CY, Ng KL, Mat Junit S. Functional analyses of C.2268dup in thyroid peroxidase gene associated with goitrous congenital hypothyroidism. Biomed Res Int. 2014;2014:370538. doi: 10.1155/2014/370538. Epub 2014 Mar 17.
- Nascimento AC, Guedes DR, Santos CS, Knobel M, Rubio IG, Medeiros-Neto G. Thyroperoxidase gene mutations in congenital goitrous hypothyroidism with total and partial iodide organification defect. Thyroid. 2003 Dec;13(12):1145-51. doi: 10.1089/10507250360731550.
- Rivolta CM, Esperante SA, Gruneiro-Papendieck L, Chiesa A, Moya CM, Domene S, Varela V, Targovnik HM. Five novel inactivating mutations in the thyroid peroxidase gene responsible for congenital goiter and iodide organification defect. Hum Mutat. 2003 Sep;22(3):259. doi: 10.1002/humu.9175.
تاريخ المقال
المقال متاح أيضًا باللغة الإنجليزية, الألمانية, إسبانية, الفرنسية, إيطالي, البرتغالية, الهندية, العبرية, العربية ,، و السويدية.
18 Aug 2020 | أحدث إصدار
1 Sept 2015 | نُشر في الأصل
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