Can I take Amlodipine, Valsartan and Nebivolol together?

Why this happens

All three medicines work to lower blood pressure but in different ways. Amlodipine relaxes blood vessels, valsartan blocks a hormone that narrows vessels, and nebivolol slows the heart rate. When combined, their effects add together (additive effect).

What you should do

Use with caution. Your doctor has likely prescribed this combination intentionally, but you should monitor your blood pressure and heart rate regularly. If you feel very dizzy, tired, or notice a very slow pulse, contact your doctor. To avoid dizziness, stand up slowly from a sitting or lying position.

Important precautions

Pregnancy

You must not take valsartan if you are pregnant or planning to become pregnant. It can cause serious harm or death to an unborn baby, particularly if used in the second and third trimesters. Use effective contraception while taking it.

Asthma or COPD

Do not take nebivolol if you have asthma, a history of wheezing, or severe chronic obstructive pulmonary disease (COPD), as it can cause life-threatening narrowing of the airways.

High potassium levels (Hyperkalaemia)

Valsartan can significantly increase potassium levels in your blood. Avoid using salt substitutes containing potassium and be cautious with potassium supplements, as high levels can cause dangerous heart rhythm problems.

Food and drink warnings

Grapefruit juice

Grapefruit juice can increase the amount of amlodipine in your blood, which may cause your blood pressure to drop too low and increase the risk of side effects like headaches or swollen ankles. Avoid drinking large amounts of grapefruit juice.

Alcohol

Drinking alcohol can increase the blood-pressure-lowering effect of these medicines, which may make you feel dizzy, lightheaded, or faint, especially when standing up. It is best to keep your alcohol intake within recommended limits and see how the medicine affects you first.

Using other medicines

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.