Can I take Aspirin and Vitamin D2 together?
Drug interaction guide
Originally published 25 Jan 2026
Meets Patient’s editorial guidelines
- DownloadDownload
- Share
- Language
- Discussion
- Audio Version
- Add to preferred sources on Google
There are no known significant interactions between aspirin and vitamin D2 (ergocalciferol). It is generally considered safe to take these two medications together.
Why this happens
Aspirin and vitamin D2 are processed by the body through different pathways. Aspirin works by blocking certain enzymes to reduce pain and inflammation, while vitamin D2 is a fat-soluble vitamin that helps the body absorb calcium. They do not interfere with each other's absorption, metabolism, or effectiveness.
What you should do
You can continue to take both as prescribed or recommended. As with any supplement or medication, ensure you are taking the correct dose of vitamin D2 as advised by your healthcare professional, as excessively high doses of vitamin D can lead to high calcium levels.
Important precautions
Asthma
Do not take this medicine if you have a history of asthma triggered by aspirin or other non-steroidal anti-inflammatory drugs (NSAIDs), as it can cause a severe, life-threatening allergic reaction or asthma attack.
Pregnancy (third trimester)
You must not take aspirin during the last three months of pregnancy (from 28 weeks) as it can cause serious heart and kidney problems in the unborn baby and increase the risk of bleeding during delivery.
Children and teenagers under 16 years old
Never give aspirin to children or teenagers under 16 unless specifically prescribed by a doctor. It can cause Reye’s syndrome, a rare but potentially fatal condition that causes serious liver and brain damage.
Food and drink warnings
Alcohol
Drinking alcohol while taking aspirin can increase the risk of stomach irritation and bleeding. It is best to limit alcohol intake or avoid it if you have a history of stomach issues.
Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
Patient picks for Drug interactions

Drug interactions checker
Can I take Ashwagandha and Vitamin B12 together?
There are no known clinical interactions between ashwagandha and vitamin B12. It is generally considered safe to take these two supplements together.

Drug interactions checker
Can I take Magnesium and Wegovy flextouch together?
There is no known direct interaction between magnesium supplements and Wegovy (semaglutide). However, both can affect your digestive system. Wegovy slows down how quickly your stomach empties, which could theoretically change how quickly your body absorbs magnesium, though this is rarely a clinical concern. Additionally, both can cause side effects like nausea or changes in bowel habits (magnesium often softens stools, while Wegovy can cause constipation or diarrhoea).
Article history
The information on this page is written and peer reviewed by qualified clinicians.
Article also available in English, German, Spanish, French, Italian, Portuguese, Hindi, Hebrew, Arabic, and Swedish.
25 Jan 2026 | Originally published

Ask, share, connect.
Browse discussions, ask questions, and share experiences across hundreds of health topics.

Feeling unwell?
Assess your symptoms online for free
Sign up to the Patient newsletter
Your weekly dose of clear, trustworthy health advice - written to help you feel informed, confident and in control.
By subscribing you accept our Privacy Policy. You can unsubscribe at any time. We never sell your data.
More in drug interactions checker
- Can I take Amitriptyline and Losartan together?
- Can I take Amlodipine and Aspirin together?
- Can I take Atorvastatin and Spironolactone together?
- Can I take Black garlic and Rosehip together?
- Can I take Cannabis and Clozapine together?
- Can I take Certican (Everolimus) and Matcha together?
- Can I take Esomeprazole and Sertraline together?
- Can I take Estradot and Hormone replacement together?
- Can I take Fexofenadine and Tizanidine together?
- Can I take Hydroxocobalamin and Clopidogrel together?
- Can I take Ibuprofen gel 10% and Oxycodone together?
- Can I take Lansoprazole and Mirabegron together?
- Can I take Magnesium and Oestrogel pump-pack together?
- Can I take Naproxen and Oxycodone together?
- Can I take Pancreatin and Solifenacin together?
- Can I take Paracetamol and Ropinirole together?
- Can I take Quetiapine and Sertraline together?
- Can I take Ramipril and Sertraline together?
- Can I take Royal sun and Turkey tail together?
- Can I take Statins and Grapefruit together?