Can I take Colecalciferol and Evolocumab together?

Why this happens

You can take colecalciferol and evolocumab together. These drugs work in completely different ways and do not interfere with how the body absorbs, breaks down, or removes the other.

Colecalciferol is a vitamin used to maintain bone health and calcium levels, while evolocumab is a monoclonal antibody used to lower cholesterol by acting on a specific protein in the liver (PCSK9).

What you should do

You can safely take both medications as prescribed by your doctor. You do not need to change the timing of your doses or take any special precautions when using them together. Always ensure your doctor is aware of all supplements you are taking, including Vitamin D.

Important precautions

Hypercalcaemia (high blood calcium)

Do not take colecalciferol if you have high levels of calcium in your blood or urine, or if you have severe kidney stones, as vitamin D increases calcium absorption and can worsen these conditions.

Latex allergy - evolocumab

The needle cover of the pre-filled pen or syringe contains dry natural rubber (a derivative of latex), which may cause severe allergic reactions in people with a latex sensitivity.

Food and drink warnings

Alcohol

It is best to avoid or strictly limit alcohol while taking colecalciferol. Long-term heavy alcohol use can interfere with how your body absorbs and processes Vitamin D, making the treatment less effective.

It is best to avoid or strictly limit alcohol while taking evolocumab. Combining alcohol with cholesterol-lowering treatments can increase the risk of liver strain or damage.

High-fat meals

Colecalciferol is a fat-soluble vitamin. It is best absorbed by your body when taken with a meal that contains some fat (such as eggs, avocado, nuts, or dairy).

Using other medicines

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.