Can I take Esomeprazole and Trazodone together?

لماذا يحدث هذا

Esomeprazole reduces stomach acid. Trazodone needs an acidic environment to dissolve properly so it can be absorbed into the bloodstream. Lower acid levels mean less medicine gets into your system. There is also a theoretical risk of 'QT prolongation' (a change in heart rhythm) when these types of drugs are used together.

You can generally take these together, but monitor your mood or sleep patterns closely. If you feel your trazodone is not working as well as it used to, or if you experience any unusual heart palpitations or dizziness, speak with your doctor. They may need to adjust your dose or the timing of when you take your tablets.

Depression and mental health disorders

Trazodone can increase thoughts of self-harm or suicide, particularly when first starting the medicine or changing the dose. Monitor your mood closely and seek urgent medical help if you experience any distressing thoughts.

Drowsiness and alcohol interaction

Trazodone is highly sedating. You must not drink alcohol while taking it as this will dangerously increase the sedative effect. Do not drive or operate machinery until you know how it affects you.

Priapism (prolonged erection)

In rare cases, trazodone can cause a painful, persistent erection. If you experience an erection lasting more than two hours, seek emergency medical help immediately to prevent permanent damage.

Severe diarrhoea (C. difficile) - esomeprazole

Seek medical help if you develop severe or persistent watery diarrhoea, as this medicine can increase the risk of a serious bowel infection.

نقص فيتامين ب12 وكسور العظام - إيزوميبرازول

الاستخدام طويل الأمد (أكثر من سنة) يمكن أن يضعف العظام ويؤدي إلى انخفاض مستويات المغنيسيوم أو فيتامين B12؛ يجب على طبيبك مراقبة هذه المستويات إذا كنت تتلقى علاجًا طويل الأمد.

مرض الكلى أو الكبد الحاد

قد يحتاج طبيبك إلى وصف جرعة أقل، حيث سيستغرق جسمك وقتًا أطول للتخلص من الإيزوميبرازول.

نقص المغنيسيوم

Taking esomeprazole for more than three months can cause your blood magnesium levels to drop significantly, leading to fatigue, muscle spasms, or dizziness.

إخفاء أعراض سرطان المعدة

يمكن أن يخفي إيزوميبرازول أعراض سرطان المعدة. يجب أن تخبر طبيبك إذا كنت تعاني من فقدان وزن غير مبرر، أو قيء مستمر، أو صعوبة في البلع قبل بدء هذا الدواء.

الكحول

While alcohol does not directly interact with esomeprazole, it can increase stomach acid production and irritate the stomach lining, which may worsen the symptoms your medicine is intended to treat. It is best to limit alcohol intake.

It is best to avoid or strictly limit alcohol while taking trazodone. Alcohol can significantly increase the sedative effects of this medicine, making you feel very sleepy, dizzy, or unsteady on your feet. It can also increase the risk of breathing difficulties.

عصير الجريب فروت

Avoid drinking large amounts of grapefruit juice. Grapefruit can increase the level of trazodone in your blood, which may increase the risk of side effects.

الكافيين

Caffeine (found in coffee, tea, and some fizzy drinks) can trigger or worsen acid reflux and heartburn. This may make esomeprazole less effective at managing your symptoms.

الطعام (عام)

Trazodone should ideally be taken with or shortly after a meal or a snack. Taking it on an empty stomach can increase the risk of feeling dizzy or lightheaded.

Taking multiple medicines? Our مدقق تفاعلات الأدوية helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

إخلاء المسؤولية

هذه المعلومات لأغراض تعليمية عامة فقط ولا ينبغي الاعتماد عليها كبديل للنصيحة الطبية المهنية. استشر دائمًا طبيبك العام أو الصيدلي أو أي متخصص رعاية صحية مؤهل آخر قبل اتخاذ قرارات بشأن أدويتك. قد تختلف الظروف الفردية، ولا يمكن إلا لمتخصص الرعاية الصحية الذي يعرف تاريخك الطبي تقديم إرشادات مخصصة.