Maternally inherited diabetes and deafness
آخر تحديث 19 يوليو 2023
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Maternally inherited diabetes and deafness (MIDD) is a form of diabetes that is often accompanied by hearing loss, especially of high tones. The diabetes in MIDD is characterised by high blood sugar (glucose) levels, known as hyperglycemia. This results from a shortage of the hormone insulin, which regulates the amount of glucose in the blood. In MIDD, the diabetes and hearing loss usually develop in mid-adulthood, although the age that they occur varies from childhood to late adulthood. Typically, hearing loss occurs before diabetes.
الوصف
Maternally inherited diabetes and deafness (MIDD) is a form of diabetes that is often accompanied by hearing loss, especially of high tones. The diabetes in MIDD is characterised by high blood sugar (glucose) levels, known as hyperglycemia. This results from a shortage of the hormone insulin, which regulates the amount of glucose in the blood. In MIDD, the diabetes and hearing loss usually develop in mid-adulthood, although the age that they occur varies from childhood to late adulthood. Typically, hearing loss occurs before diabetes.
Some people with MIDD develop an eye disorder called macular retinal dystrophy, which is characterised by colored patches in the light-sensitive tissue that lines the back of the eye (the retina). This disorder does not usually cause vision problems in people with MIDD. Individuals with MIDD also may experience muscle cramps or weakness, particularly during exercise; heart problems; kidney disease; and constipation. Individuals with MIDD are often shorter than their peers.
Inheritance patterns
The source lists the following possible inheritance patterns: mitochondrial. More than one pattern can apply in different cases.
Related genes
Other names
Ballinger-Wallace syndrome
Diabetes mellitus, type II, with deafness
Maternally transmitted diabetes-deafness syndrome
MIDD
Mitochondrial inherited diabetes and deafness
NIDDM with deafness
Noninsulin-dependent diabetes mellitus with deafness
Related patient information and medicines
Patient information leaflet
السكري
Pregnant women who have never had diabetes before but who have high blood glucose levels during pregnancy have gestational diabetes. Gestational diabetes usually goes away after birth, but women who have had gestational diabetes are more likely to develop type 2 diabetes in future. Gestational diabetes affects about 4% of all pregnant women. See.
Patient information leaflet
قصور الغدة الجار درقية
ينتقل عبر الجينات من أفراد العائلة (وراثي). It is eventually released and all returns to normal. قصور الغدة الجار درقية العابر هو more likely to affect a baby if the mother has diabetes, or the mother has overactive parathyroid glands. The parathyroid glands do not develop properly while the baby is growing in the womb. One example.
Patient information leaflet
السكري والحمل
النساء who have diabetes need extra care during pregnancy. They should ideally seek medical advice from their specialist team when considering starting their family. What is gestational diabetes. Gestational diabetes mellitus (GDM) is the name for diabetes which starts for the first time during pregnancy and which usually resolves soon after giving.
Patient information leaflet
داء السكري الكاذب
داء السكري الكاذب is a rare condition where the body هو unable إلى control the balance of water. People with diabetes insipidus become very thirsty and pee a lot. What is diabetes insipidus. Roughly 1 in 5 people taking long-term lithium develop some level of nephrogenic diabetes insipidus. Gestational diabetes insipidus This occurs in pregnant.
Patient information leaflet
داء السكري من النوع 1
داء السكري من النوع 1 هو the type of diabetes that typically develops in children and in young adults. In type 1 diabetes the body stops making insulin and the blood sugar (glucose) level goes very high. This happens because some cells and chemicals in ... Is type 1 diabetes inherited. Although type 1 diabetes is not an inherited disease, there is a.
Patient information leaflet
ارتفاع السكر في الدم غير السكري (ما قبل السكري)
If a woman has polycystic ovary syndrome and is also overweight. إذا أصبتِ بمرض السكري أثناء الحمل (يسمى سكري الحمل). NDH symptoms People with NDH usually have no symptoms. People with an HbA1c... Another test to diagnose NDH is the glucose tolerance test but this is used much less often now - the most common reason for doing.
قراءة إضافية ومراجع
- Maternally inherited diabetes and deafness; MedlinePlus, National Library of Medicine.
- Kameoka K, Isotani H, Tanaka K, Kitaoka H, Ohsawa N. Impaired insulin secretion in Japanese diabetic subjects with an A-to-G mutation at nucleotide 8296 of the mitochondrial DNA in tRNA(Lys). Diabetes Care. 1998 Nov;21(11):2034-5. doi: 10.2337/diacare.21.11.2034. No abstract available.
- Maassen JA, Jahangir Tafrechi RS, Janssen GM, Raap AK, Lemkes HH, 't Hart LM. New insights in the molecular pathogenesis of the maternally inherited diabetes and deafness syndrome. Endocrinol Metab Clin North Am. 2006 Jun;35(2):385-96, x-xi. doi: 10.1016/j.ecl.2006.02.014.
- Murphy R, Turnbull DM, Walker M, Hattersley AT. Clinical features, diagnosis and management of maternally inherited diabetes and deafness (MIDD) associated with the 3243A>G mitochondrial point mutation. Diabet Med. 2008 Apr;25(4):383-99. doi: 10.1111/j.1464-5491.2008.02359.x. Epub 2008 Feb 18.
- Supale S, Li N, Brun T, Maechler P. Mitochondrial dysfunction in pancreatic beta cells. Trends Endocrinol Metab. 2012 Sep;23(9):477-87. doi: 10.1016/j.tem.2012.06.002. Epub 2012 Jul 4.
- van den Ouweland JM, Lemkes HH, Ruitenbeek W, Sandkuijl LA, de Vijlder MF, Struyvenberg PA, van de Kamp JJ, Maassen JA. Mutation in mitochondrial tRNA(Leu)(UUR) gene in a large pedigree with maternally transmitted type II diabetes mellitus and deafness. Nat Genet. 1992 Aug;1(5):368-71. doi: 10.1038/ng0892-368.
- Vialettes BH, Paquis-Flucklinger V, Pelissier JF, Bendahan D, Narbonne H, Silvestre-Aillaud P, Montfort MF, Righini-Chossegros M, Pouget J, Cozzone PJ, Desnuelle C. Phenotypic expression of diabetes secondary to a T14709C mutation of mitochondrial DNA. Comparison with MIDD syndrome (A3243G mutation): a case report. Diabetes Care. 1997 Nov;20(11):1731-7. doi: 10.2337/diacare.20.11.1731.
تاريخ المقال
المقال متاح أيضًا باللغة الإنجليزية, الألمانية, إسبانية, الفرنسية, إيطالي, البرتغالية, الهندية, العبرية, العربية ,، و السويدية.
19 يوليو 2023 | أحدث إصدار
1 Oct 2012 | نُشر في الأصل
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