APC regulator of Wnt signaling pathway
آخر تحديث 26 Aug 2025
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The APC gene provides instructions for making the APC protein, which plays a critical role in several cellular processes. The APC protein acts as a tumour suppressor, which means that it keeps cells from growing and dividing too fast or in an uncontrolled way. This protein blocks a chemical signaling pathway known as Wnt signaling. This pathway promotes cell growth and division (proliferation) and controls the activity (expression) of certain genes.
Normal function
The APC gene provides instructions for making the APC protein, which plays a critical role in several cellular processes. The APC protein acts as a tumour suppressor, which means that it keeps cells from growing and dividing too fast or in an uncontrolled way. This protein blocks a chemical signaling pathway known as Wnt signaling. This pathway promotes cell growth and division (proliferation) and controls the activity (expression) of certain genes.
The APC protein attaches (binds) to multiple proteins to form a complex that helps to control levels of another protein called beta-catenin. Beta-catenin is a key part of the Wnt pathway, and it helps control many cell functions, including cell proliferation, gene expression, and the process by which cells mature to carry out specific functions (differentiation). When the APC protein complex binds beta-catenin, it helps break the protein down when it is no longer needed.
The APC protein also plays a role in regulating cell division. The protein interacts with parts of the cell's structural framework (cytoskeleton) to help with proper cell organisation during cell division. This helps ensure that the number of chromosomes in a cell is correct after the cell divides.
Conditions referring to this gene or chromosome
Other names
adenomatous polyposis coli
APC_HUMAN
WNT signaling pathway regulator
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قراءة إضافية ومراجع
- APC regulator of Wnt signaling pathway; MedlinePlus, National Library of Medicine.
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- Yen T, Stanich PP, Axell L, Patel SG. APC-Associated Polyposis Conditions. 1998 Dec 18 [updated 2022 May 12]. In: Adam MP, Bick S, Mirzaa GM, Wallace SE, Amemiya A, editors. GeneReviews(R) [Internet]. Seattle (WA): University of Washington, Seattle; 1993-2026. Available from http://www.ncbi.nlm.nih.gov/books/NBK1345/
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المقال متاح أيضًا باللغة الإنجليزية, الألمانية, إسبانية, الفرنسية, إيطالي, البرتغالية, الهندية, العبرية, العربية ,، و السويدية.
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