calcium voltage-gated channel subunit alpha1 C
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ال CACNA1C gene provides instructions for making one of several calcium channels. Calcium channels, which transport positively charged calcium atoms (calcium ions) into cells, play a key role in a cell's ability to generate electrical signals. Calcium ions are important for many cellular functions, including regulating the electrical activity of cells, cell-to-cell communication, the tensing of muscle fibers (muscle contraction), and the regulation of certain genes, particularly those involved in the development of the brain and bones before birth.
Normal function
ال CACNA1C gene provides instructions for making one of several calcium channels. Calcium channels, which transport positively charged calcium atoms (calcium ions) into cells, play a key role in a cell's ability to generate electrical signals. Calcium ions are important for many cellular functions, including regulating the electrical activity of cells, cell-to-cell communication, the tensing of muscle fibers (muscle contraction), and the regulation of certain genes, particularly those involved in the development of the brain and bones before birth.
The calcium channel produced from the CACNA1C gene is known as CaV1.2. These channels are found in many types of cells, although they appear to be particularly important for the function of heart cells (cardiomyocytes) and nerve cells (neurons) in the brain. In the heart, CaV1.2 channels open and close at specific times to control the flow of calcium ions into cardiomyocytes at each heartbeat. How long the channels are open and closed is regulated to maintain normal heart function. In the brain, CaV1.2 channels are thought to be involved in memory, the fear response, and the rapid transmission of nerve signals; however, the role of these channels in the brain and other tissues is not completely understood.
Researchers have discovered that many different versions (isoforms) of the CaV1.2 channel can be produced from the CACNA1C gene by a mechanism called alternative splicing. This mechanism produces different versions of the channel by cutting and rearranging the genetic instructions in different ways. Some versions of the CaV1.2 channel are more common than others in certain parts of the body. For example, in the heart and brain, about 80 percent of CaV1.2 channels are made with a particular segment known as exon 8. The other 20 percent of CaV1.2 channels contain a slightly different version of this segment, known as exon 8A. This difference becomes important when researchers are studying the effects of CACNA1C mutations in various tissues.
Conditions referring to this gene or chromosome
Other names
CAC1C_HUMAN
CACH2
CACN2
CACNL1A1
calcium channel, cardic dihydropyridine-sensitive, alpha-1 subunit
calcium channel, L type, alpha 1 polypeptide, isoform 1, cardic muscle
calcium channel, voltage-dependent, L type, alpha 1C subunit
CaV1.2
CCHL1A1
DHPR, alpha-1 subunit
MGC120730
voltage-dependent L-type calcium channel alpha 1C subunit
voltage-gated calcium channel alpha subunit Cav1.2
Related patient information and medicines
Patient information leaflet
أمراض صمامات القلب
The leaflet called Anatomy of the heart includes details about the function of. What is heart valve disease. If rheumatic fever is the cause then symptoms often start between the ages of 20 and 50 years, about 10-20 years after having had an episode of rheumatic fever as a child. Other causes of heart valve disease Other causes of heart valve.
Patient information leaflet
هل يمكنني تناول ليفوثيروكسين وفيلوديبين معًا؟
Taking levothy... If your thyroid levels are not well-controlled, it can change how your body processes the blood pressure medication. Why this happens ليفوثيروكسين is a thyroid hormone, and felodipine هو a calcium channel blocker used for high blood pressure. Thyroid hormones affect your metabolism. If you are hyperthyroid (too much hormone) or.
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The cancer grows and forms into a tumour within the kidney. As the tumour grows: The affected kidney tends to become larger. In time the tumour may grow through the wall of the kidney and invade nearby tissues and organs, such as the muscles around the spine, the liver, the nearby large blood vessels, etc. Some cells may break off into the lymph.
Patient information leaflet
هل يمكنني تناول أملوديبين وميتفورمين معًا؟
Amlodipine may slightly reduce t... This means your blood sugar levels might be a little higher than usual when taking both medicines together. Why this happens أملوديبين belongs to a class of drugs called calcium channel blockers. These can sometimes interfere with how the body releases insulin and how it processes sugar, which can slightly.
Patient information leaflet
هل يمكنني تناول ليركانيديبين وليفوثيروكسين معًا؟
However, if your thyroid levels are not well-controlled, it can affect how your blood pressure medication works. Why this happens Lercanidipine هو a calcium channel blocker used for high blood pressure, و ليفوثيروكسين is a hormone replacement for an underactive thyroid. They do not interfere with each other's absorption or metabolism. However,.
Patient information leaflet
هل يمكنني تناول كوليكالسيفيرول وبريجابالين معًا؟
It is generally considered safe to take these t... Why this happens Colecalciferol (Vitamin D3) and pregabalin are processed by the body through different pathways. Colecalciferol is a fat-soluble vitamin involved in calcium regulation, while بريجابالين works on specific calcium channels in the nervous system إلى treat pain or anxiety. They do not.
قراءة إضافية ومراجع
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تاريخ المقال
المقال متاح أيضًا باللغة الإنجليزية, الألمانية, إسبانية, الفرنسية, إيطالي, البرتغالية, الهندية, العبرية, العربية ,، و السويدية.
13 مارس 2023 | أحدث إصدار
1 Feb 2020 | نُشر في الأصل
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