cytochrome P450 family 11 subfamily B member 2

Normal function

ال CYP11B2 gene provides instructions for making an enzyme called aldosterone synthase (previously known as corticosterone methyloxidase). This enzyme is found in the adrenal glands, which are located on top of the kidneys. Aldosterone synthase is a member of the cytochrome P450 family of enzymes. These enzymes are involved in the formation and breakdown of various molecules within cells.

Aldosterone synthase helps produce a hormone called aldosterone. Aldosterone helps control blood pressure by maintaining proper salt and fluid levels in the body. The aldosterone synthase enzyme is involved in a series of three chemical reactions that produce aldosterone from other (precursor) molecules: the conversion of 11-deoxycorticosterone to corticosterone, the conversion of corticosterone to 18-hydroxycorticosterone, and the conversion of 18-hydroxycorticosterone to aldosterone.

Conditions referring to this gene or chromosome

• Familial hyperaldosteronism

• Corticosterone methyloxidase deficiency

Other names

ALDOS

aldosterone synthase

aldosterone-synthesizing enzyme

C11B2_HUMAN

CPN2

CYP11B

CYP11BL

CYPXIB2

cytochrome P-450Aldo

cytochrome P-450C18

cytochrome P450 11B2, mitochondrial

cytochrome P450 11B2, mitochondrial precursor

cytochrome P450, family 11, subfamily B, polypeptide 2

cytochrome P450, subfamily XIB (steroid 11-beta-hydroxylase), polypeptide 2

mitochondrial cytochrome P450, family 11, subfamily B, polypeptide 2

P-450C18

P450aldo

P450C18

steroid 11-beta-monooxygenase

steroid 11-beta/18-hydroxylase

steroid 18-hydroxylase, aldosterone synthase, P450C18, P450aldo