dynein axonemal heavy chain 11
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The DNAH11 gene provides instructions for making a protein that is part of a larger group (a complex) of proteins called dynein. This complex functions within cell structures called cilia. Cilia are microscopic, finger-like projections that stick out (project) from the surface of cells. They are found in cells that line the airway, the reproductive system, and many other organs and tissues. Coordinated back and forth movement of cilia can move the cell or the fluid surrounding the cell. Dynein makes up the structures (arms) that produce the force needed for cilia to move.
Normal function
The DNAH11 gene provides instructions for making a protein that is part of a larger group (a complex) of proteins called dynein. This complex functions within cell structures called cilia. Cilia are microscopic, finger-like projections that stick out (project) from the surface of cells. They are found in cells that line the airway, the reproductive system, and many other organs and tissues. Coordinated back and forth movement of cilia can move the cell or the fluid surrounding the cell. Dynein makes up the structures (arms) that produce the force needed for cilia to move.
Dynein forms structures known as inner dynein arms (IDAs) and outer dynein arms (ODAs) within the core of many cilia (the axoneme). Coordinated movement of the dynein arms causes the entire axoneme to bend back and forth. Within IDAs and ODAs, dynein is made up of different combinations of protein components (subunits) that are classified by weight as heavy, intermediate, or light chains. The DNAH11 gene provides instructions for making the heavy chain 11 protein, which is found in ODAs. Other subunits are produced from different genes.
Conditions referring to this gene or chromosome
Other names
DNAHBL
DNAHC11
DPL11
dynein heavy chain beta-like
dynein, axonemal, heavy polypeptide 11
dynein, ciliary, heavy chain 11
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قراءة إضافية ومراجع
- dynein axonemal heavy chain 11; MedlinePlus, National Library of Medicine.
- Despotes KA, Zariwala MA, Davis SD, Ferkol TW. Primary Ciliary Dyskinesia: A Clinical Review. Cells. 2024 Jun 4;13(11):974. doi: 10.3390/cells13110974.
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- Schultz R, Elenius V, Lukkarinen H, Saarela T. Two novel mutations in the DNAH11 gene in primary ciliary dyskinesia (CILD7) with considerable variety in the clinical and beating cilia phenotype. BMC Med Genet. 2020 Nov 26;21(1):237. doi: 10.1186/s12881-020-01171-2.
- Sironen A, Shoemark A, Patel M, Loebinger MR, Mitchison HM. Sperm defects in primary ciliary dyskinesia and related causes of male infertility. Cell Mol Life Sci. 2020 Jun;77(11):2029-2048. doi: 10.1007/s00018-019-03389-7. Epub 2019 Nov 28.
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- Zariwala MA, Despotes KA, Davis SD. Primary Ciliary Dyskinesia. 2007 Jan 24 [updated 2025 May 22]. In: Adam MP, Bick S, Mirzaa GM, Wallace SE, Amemiya A, editors. GeneReviews(R) [Internet]. Seattle (WA): University of Washington, Seattle; 1993-2026. Available from http://www.ncbi.nlm.nih.gov/books/NBK1122/
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المقال متاح أيضًا باللغة الإنجليزية, الألمانية, إسبانية, الفرنسية, إيطالي, البرتغالية, الهندية, العبرية, العربية ,، و السويدية.
23 Sept 2025 | أحدث إصدار
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