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coagulation factor XIII B chain

آخر تحديث 18 Aug 2020

يتوافق مع الإرشادات التحريرية

ال F13B gene provides instructions for making one part, the B subunit, of a protein called factor XIII. This protein is part of a group of related proteins called coagulation factors that are essential for normal blood clotting. They work together as part of the coagulation cascade, which is a series of chemical reactions that forms blood clots in response to injury. After an injury, clots seal off blood vessels to stop bleeding and trigger blood vessel repair. Factor XIII acts at the end of the cascade to strengthen and stabilize newly formed clots, preventing further blood loss.

Normal function

ال F13B gene provides instructions for making one part, the B subunit, of a protein called factor XIII. This protein is part of a group of related proteins called coagulation factors that are essential for normal blood clotting. They work together as part of the coagulation cascade, which is a series of chemical reactions that forms blood clots in response to injury. After an injury, clots seal off blood vessels to stop bleeding and trigger blood vessel repair. Factor XIII acts at the end of the cascade to strengthen and stabilize newly formed clots, preventing further blood loss.

Factor XIII in the bloodstream is made of two A subunits (produced from the F13A1 gene) and two B subunits (produced from the F13B gene). The role of the B subunits is to carry and stabilize the A subunits, protecting them from being broken down. When a new blood clot forms, the A and B subunits separate from one another, and the A subunits are cut (cleaved) to produce the active form of factor XIII (factor XIIIa). The active protein links together molecules of fibrin, the material that forms the clot, which strengthens the clot and keeps other molecules from breaking it down.

Studies suggest that factor XIII has additional functions, although these are less well understood than its role in blood clotting. Specifically, factor XIII is likely involved in other aspects of wound healing, immune system function, maintaining pregnancy, bone formation, and the growth of new blood vessels (angiogenesis).

Conditions referring to this gene or chromosome

Other names

coagulation factor XIII B chain precursor

coagulation factor XIII, B polypeptide

fibrin-stabilizing factor B subunit

FXIIIB

protein-glutamine gamma-glutamyltransferase B chain

TGase

transglutaminase B chain

Related clinical trials

Related patient information and medicines

اختبارات تخثر الدم

Patient information leaflet

اختبارات تخثر الدم

اختبارات تخثر الدم are used to diagnose and assess bleeding problems and to monitor people who take الوارفارين or other مضاد للتخثر medicines. You may be advi... These chemicals then react with other chemicals and proteins in the plasma, called clotting factors. There are 13 known clotting factors which are called by their Roman numbers - factor.

مضادات التخثر

Patient information leaflet

مضادات التخثر

Within seconds of cutting a blood vessel, the damaged tissue causes tiny cells in the blood (platelets) to become sticky and clump ... These activated platelets and the damaged tissue release chemicals which react with other chemicals and proteins in the blood, called clotting factors. There are 13 known clotting factors which are called by their.

تخثر الدم

Patient information leaflet

تخثر الدم

ال normal clotting process is called haemostasis. It helps to stop bleeding if you have an injury such as a cut. When a blood vessel is injured, the clotting process is triggered. This is called the clotting cascade. It is a chain reaction من different chemicals in the دم which are called clotting factors. The clotting cascade makes the blood.

متلازمة الأجسام المضادة للفوسفوليبيد

Patient information leaflet

متلازمة الأجسام المضادة للفوسفوليبيد

Primary and secondary APS are still commonly used terms. However, most people now say 'APS with or without associat... The presence of the antiphospholipid antibodies causes the increased tendency of the blood to clot - they can trigger the coagulation cascade. The coagulation cascade is a chain reaction of events or chemical reactions that occur.

مريء باريت

Patient information leaflet

مريء باريت

The coil then emits heat energy which destroys the abnormal cells. Nearby normal cells then multiply and replace the destroyed abnormal cells. Argon plasma coagulation This treatment uses a jet of argon gas, together with an electric current, to burn away dysplastic cells. Endoscopic mucosal resection (EMR) This is a procedure that is done via.

هل يمكنني تناول أبيكسابان وبيسوبرولول معًا؟

Patient information leaflet

هل يمكنني تناول أبيكسابان وبيسوبرولول معًا؟

There is no direct interaction between apixaban and bisoprolol. They work in different ways and do not interfere with how the body processes each other. Why this happens أبيكسابان هو anticoagulant (blood thinner) that works by blocking a clotting factor called Factor Xa. Bisoprolol is a beta-blocker that slows the heart rate and lowers blood.

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  • 18 Aug 2020 | أحدث إصدار
  • 1 Aug 2015 | نُشر في الأصل

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