Fli-1 proto-oncogene, ETS transcription factor
آخر تحديث 18 Aug 2020
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ال FLI1 gene provides instructions for making the FLI protein, which controls the activity (transcription) of genes. Transcription is the first step in the process of producing proteins. The FLI protein is part of a group of related proteins, called the Ets family of transcription factors, that control transcription. The FLI protein attaches (binds) to certain regions of DNA and turns on (activates) the transcription of nearby genes. The proteins produced from these genes control many important cellular processes, such as cell growth and division (proliferation), maturation (differentiation), and survival. The FLI protein is found primarily in blood cells and is thought to regulate their development.
Normal function
ال FLI1 gene provides instructions for making the FLI protein, which controls the activity (transcription) of genes. Transcription is the first step in the process of producing proteins. The FLI protein is part of a group of related proteins, called the Ets family of transcription factors, that control transcription. The FLI protein attaches (binds) to certain regions of DNA and turns on (activates) the transcription of nearby genes. The proteins produced from these genes control many important cellular processes, such as cell growth and division (proliferation), maturation (differentiation), and survival. The FLI protein is found primarily in blood cells and is thought to regulate their development.
Conditions referring to this gene or chromosome
Other names
EWSR2
FLI1_HUMAN
Friend leukemia integration 1 transcription factor
Friend leukemia virus integration 1
proto-oncogene Fli-1
SIC-1
transcription factor ERGB
Related patient information and medicines
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ابيضاض الدم الليمفاوي الحاد
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لقاح 6 في 1
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اختبارات تخثر الدم
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علاج مرض السكري من النوع 2
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Patient information leaflet
أسباب السرطان
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Patient information leaflet
هل يمكنني تناول أبيكسابان وريبيلسوس معًا؟
These two medicines work in different ways and do not typically interfere with how the other is absorbed, broken down, or removed from the body. Why this happens أبيكسابان هو anticoagulant (blood thinner) that works by blocking a clotting factor called Factor Xa. Rybelsus هو a GLP-1 receptor agonist used لـ داء السكري من النوع 2 that mimics a natural.
قراءة إضافية ومراجع
- Fli-1 proto-oncogene, ETS transcription factor; MedlinePlus, National Library of Medicine.
- Mao X, Miesfeldt S, Yang H, Leiden JM, Thompson CB. The FLI-1 and chimeric EWS-FLI-1 oncoproteins display similar DNA binding specificities. J Biol Chem. 1994 Jul 8;269(27):18216-22.
- May WA, Gishizky ML, Lessnick SL, Lunsford LB, Lewis BC, Delattre O, Zucman J, Thomas G, Denny CT. Ewing sarcoma 11;22 translocation produces a chimeric transcription factor that requires the DNA-binding domain encoded by FLI1 for transformation. Proc Natl Acad Sci U S A. 1993 Jun 15;90(12):5752-6. doi: 10.1073/pnas.90.12.5752.
- May WA, Lessnick SL, Braun BS, Klemsz M, Lewis BC, Lunsford LB, Hromas R, Denny CT. The Ewing's sarcoma EWS/FLI-1 fusion gene encodes a more potent transcriptional activator and is a more powerful transforming gene than FLI-1. Mol Cell Biol. 1993 Dec;13(12):7393-8. doi: 10.1128/mcb.13.12.7393-7398.1993.
- Ohno T, Rao VN, Reddy ES. EWS/Fli-1 chimeric protein is a transcriptional activator. Cancer Res. 1993 Dec 15;53(24):5859-63.
تاريخ المقال
المقال متاح أيضًا باللغة الإنجليزية, الألمانية, إسبانية, الفرنسية, إيطالي, البرتغالية, الهندية, العبرية, العربية ,، و السويدية.
18 Aug 2020 | أحدث إصدار
1 May 2012 | نُشر في الأصل
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