glucosamine (N-acetyl)-6-sulfatase
آخر تحديث 18 Aug 2020
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ال GNS gene provides instructions for producing an enzyme called N-acetylglucosamine-6-sulfatase. This enzyme is located in lysosomes, compartments within cells that digest and recycle different types of molecules. N-acetylglucosamine-6-sulfatase is involved in the step-wise breakdown of large molecules called glycosaminoglycans (GAGs). GAGs are composed of sugar molecules that are linked together to form a long string. To break down these large molecules, individual sugars are removed one at a time from one end of the molecule. N-acetylglucosamine-6-sulfatase removes a chemical group known as a sulfate from a subset of GAGs called heparan sulfate when the sugar N-acetylglucosamine-6-sulfate is located at the end.
Normal function
ال GNS gene provides instructions for producing an enzyme called N-acetylglucosamine-6-sulfatase. This enzyme is located in lysosomes, compartments within cells that digest and recycle different types of molecules. N-acetylglucosamine-6-sulfatase is involved in the step-wise breakdown of large molecules called glycosaminoglycans (GAGs). GAGs are composed of sugar molecules that are linked together to form a long string. To break down these large molecules, individual sugars are removed one at a time from one end of the molecule. N-acetylglucosamine-6-sulfatase removes a chemical group known as a sulfate from a subset of GAGs called heparan sulfate when the sugar N-acetylglucosamine-6-sulfate is located at the end.
Conditions referring to this gene or chromosome
Other names
G6S
glucosamine-6-sulfatase
GNS_HUMAN
MGC21274
N-acetylglucosamine-6-sulfatase
N-acetylglucosamine-6-sulfatase precursor
Related patient information and medicines
Patient information leaflet
التهاب المفاصل العظمي
In particular, الغلوكوزامين and chondroitin supplements have become popular in recent years. الجلوكوزامين and chondroitin are chemicals that are p... However, the usefulness of الغلوكوزامين and chondroitin is controversial. This analysed 10 research trials of الغلوكوزامين and chondroitin supplements, involving over 3,800 patients with knee and hip.
Patient information leaflet
هل يمكنني تناول الجلوكوزامين والسوليفيناسين معًا؟
لماذا يحدث هذا الجلوكوزامين هو a supplement used for joint health, while solifenacin هو an antimuscarinic medication used for overactive bladder. Diabetes Glucosamine is an amino sugar and may affect your blood glucose levels. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your.
Patient information leaflet
هل يمكنني تناول الجلوكوزامين والمغنيسيوم معًا؟
لماذا يحدث هذا Glucosamine is an amino sugar used by the body to build cartilage, while magnesium is a mineral involved in over 300 enzyme reactions, including muscle and nerve function. Diabetes Glucosamine is an amino sugar and may affect your blood glucose levels. Disclaimer This information is for general educational purposes only and should.
Patient information leaflet
هل يمكنني تناول الجلوكوزامين ونبتة سانت جون معًا؟
There are no known significant interactions between glucosamine and St John's wort. Why this happens الجلوكوزامين هو primarily used by the body to build cartilage و does not significantly affect the liver enzymes (Cytochrome P450) that St John's wort is known to influence. S... Diabetes Glucosamine is an amino sugar and may affect your blood.
Patient information leaflet
هل يمكنني تناول أتورفاستاتين وضمان المفاصل معًا؟
Joint Assurance is a supplement that typically contains الغلوكوزامين and chondroitin. However, some people taking statins like atorvastatin report muscle aches, and very rarely, glucosamine might also cause mild muscle or joint discomfort i... Why this happens There are no known pharmacokinetic interactions (how the body processes the drug) or.
Patient information leaflet
هل يمكنني تناول فوروسيميد وضمان المفاصل معًا؟
Taking furosemide with Joint Assurance (which contains الغلوكوزامين and chondroitin) may increase the risk of bruising or bleeding if you are also taking blood-thinning medication. ...ne can sometimes affect blood sugar levels,Sulphonamide Allergy If you have a known allergy to sulphonamide antibiotics (such as sulfamethoxazole), you may also be.
قراءة إضافية ومراجع
- glucosamine (N-acetyl)-6-sulfatase; MedlinePlus, National Library of Medicine.
- Jansen AC, Cao H, Kaplan P, Silver K, Leonard G, De Meirleir L, Lissens W, Liebaers I, Veilleux M, Andermann F, Hegele RA, Andermann E. Sanfilippo syndrome type D: natural history and identification of 3 novel mutations in the GNS Gene. Arch Neurol. 2007 Nov;64(11):1629-34. doi: 10.1001/archneur.64.11.1629.
- Valstar MJ, Bertoli-Avella AM, Wessels MW, Ruijter GJ, de Graaf B, Olmer R, Elfferich P, Neijs S, Kariminejad R, Suheyl Ezgu F, Tokatli A, Czartoryska B, Bosschaart AN, van den Bos-Terpstra F, Puissant H, Burger F, Omran H, Eckert D, Filocamo M, Simeonov E, Willems PJ, Wevers RA, Niermeijer MF, Halley DJ, Poorthuis BJ, van Diggelen OP. Mucopolysaccharidosis type IIID: 12 new patients and 15 novel mutations. Hum Mutat. 2010 May;31(5):E1348-60. doi: 10.1002/humu.21234.
- Valstar MJ, Ruijter GJ, van Diggelen OP, Poorthuis BJ, Wijburg FA. Sanfilippo syndrome: a mini-review. J Inherit Metab Dis. 2008 Apr;31(2):240-52. doi: 10.1007/s10545-008-0838-5. Epub 2008 Apr 4.
تاريخ المقال
المقال متاح أيضًا باللغة الإنجليزية, الألمانية, إسبانية, الفرنسية, إيطالي, البرتغالية, الهندية, العبرية, العربية ,، و السويدية.
18 Aug 2020 | أحدث إصدار
1 Aug 2010 | نُشر في الأصل
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