SPARC related modular calcium binding 1
آخر تحديث 26 Sept 2025
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ال SMOC1 gene provides instructions for making a protein called secreted modular calcium-binding protein 1 (SMOC-1). This protein is found in basement membranes, which are thin, sheet-like structures that support cells in many tissues and help anchor cells to one another during embryonic development. The SMOC-1 protein attaches (binds) to many different proteins and is thought to regulate molecules called growth factors that stimulate the growth and development of tissues throughout the body. These growth factors play important roles in skeletal formation, normal shaping (patterning) of the limbs, as well as eye formation and development. The SMOC-1 protein also likely promotes the maturation (differentiation) of cells that build bones, called osteoblasts.
Normal function
ال SMOC1 gene provides instructions for making a protein called secreted modular calcium-binding protein 1 (SMOC-1). This protein is found in basement membranes, which are thin, sheet-like structures that support cells in many tissues and help anchor cells to one another during embryonic development. The SMOC-1 protein attaches (binds) to many different proteins and is thought to regulate molecules called growth factors that stimulate the growth and development of tissues throughout the body. These growth factors play important roles in skeletal formation, normal shaping (patterning) of the limbs, as well as eye formation and development. The SMOC-1 protein also likely promotes the maturation (differentiation) of cells that build bones, called osteoblasts.
Conditions referring to this gene or chromosome
Other names
secreted modular calcium-binding protein 1
SMOC1_HUMAN
SPARC-related modular calcium-binding protein 1
Related patient information and medicines
Patient information leaflet
هل يمكنني تناول الكالسيوم والسيبروفلوكساسين معًا؟
Taking calcium at the same time as ciprofloxacin can significantly reduce the amount of the antibiotic that gets into your bloodstream. This means the medicine may not wo... Why this happens Calcium binds to the ciprofloxacin in your stomach or gut, forming a 'complex' that is too large for your body to absorb. Instead of entering your blood, the.
Patient information leaflet
هل يمكنني تناول التتراسيكلين والكالسيوم معًا؟
Taking calcium at the same time as tetracycline can stop the antibiotic from working properly. This is because the calcium binds to the medicine in your stomach, preventing your body from absorbing it into your bloodstream to fight your infection. Why this happens This is a pharmacokinetic interaction involving absorption. Calcium is a multivalent.
Patient information leaflet
هل يمكنني تناول ليفوثيروكسين والكالسيوم معًا؟
Taking calcium at the same time as levothyroxine can stop your thyroid medication from working properly. Why this happens Calcium binds to the levothyroxine in your stomach, creating a large 'clump' that is too big for your body to absorb into the bloodstream. Disclaimer This information is for general educational purposes only and should not be.
Patient information leaflet
هل يمكنني تناول الكالسيوم والدوكسيسيكلين معًا؟
Calcium binds to the doxycycline molecules in the digestive tract to form a large complex that the body cannot absorb. High-fibre foods (bran, whole grains) and Spinach/Rhubarb Foods very high in phytic acid (grains) or oxalic acid (spinach, rhubarb) can bind to calcium and reduce its absorption. Avoid taking your calcium supplement at the same.
Patient information leaflet
هل يمكنني تناول الكالسيوم والإيزيتيميب معًا؟
There is no known interaction between calcium supplements and ezetimibe. High-fibre foods (e.g., whole grains, bran, beans) and Spinach/Rhubarb Foods very high in الألياف أو containing oxalates (like spinach و rhubarb) can bind to calcium in the digestive tract, preventing it from being absorbed properly. Try to take your calcium supplement at a.
Patient information leaflet
هل يمكنني تناول ليفوثيروكسين وفيتامين د معًا؟
Calcium binds to levothyroxine in the digestive tract, preventing the medicine from entering your bloodstream. Additionally, correcting a severe vitamin D deficiency can sometimes slightly alter how your body uses thyroid hormon... Disclaimer This information is for general educational purposes only and should not be relied upon as a substitute.
قراءة إضافية ومراجع
- SPARC related modular calcium binding 1; MedlinePlus, National Library of Medicine.
- Abouzeid H, Boisset G, Favez T, Youssef M, Marzouk I, Shakankiry N, Bayoumi N, Descombes P, Agosti C, Munier FL, Schorderet DF. Mutations in the SPARC-related modular calcium-binding protein 1 gene, SMOC1, cause waardenburg anophthalmia syndrome. Am J Hum Genet. 2011 Jan 7;88(1):92-8. doi: 10.1016/j.ajhg.2010.12.002. Epub 2010 Dec 30.
- Choi YA, Lim J, Kim KM, Acharya B, Cho JY, Bae YC, Shin HI, Kim SY, Park EK. Secretome analysis of human BMSCs and identification of SMOC1 as an important ECM protein in osteoblast differentiation. J Proteome Res. 2010 Jun 4;9(6):2946-56. doi: 10.1021/pr901110q.
- Klemencic M, Novinec M, Maier S, Hartmann U, Lenarcic B. The heparin-binding activity of secreted modular calcium-binding protein 1 (SMOC-1) modulates its cell adhesion properties. PLoS One. 2013;8(2):e56839. doi: 10.1371/journal.pone.0056839. Epub 2013 Feb 21.
- Okada I, Hamanoue H, Terada K, Tohma T, Megarbane A, Chouery E, Abou-Ghoch J, Jalkh N, Cogulu O, Ozkinay F, Horie K, Takeda J, Furuichi T, Ikegawa S, Nishiyama K, Miyatake S, Nishimura A, Mizuguchi T, Niikawa N, Hirahara F, Kaname T, Yoshiura K, Tsurusaki Y, Doi H, Miyake N, Furukawa T, Matsumoto N, Saitsu H. SMOC1 is essential for ocular and limb development in humans and mice. Am J Hum Genet. 2011 Jan 7;88(1):30-41. doi: 10.1016/j.ajhg.2010.11.012. Epub 2010 Dec 30.
- Rainger J, van Beusekom E, Ramsay JK, McKie L, Al-Gazali L, Pallotta R, Saponari A, Branney P, Fisher M, Morrison H, Bicknell L, Gautier P, Perry P, Sokhi K, Sexton D, Bardakjian TM, Schneider AS, Elcioglu N, Ozkinay F, Koenig R, Megarbane A, Semerci CN, Khan A, Zafar S, Hennekam R, Sousa SB, Ramos L, Garavelli L, Furga AS, Wischmeijer A, Jackson IJ, Gillessen-Kaesbach G, Brunner HG, Wieczorek D, van Bokhoven H, Fitzpatrick DR. Loss of the BMP antagonist, SMOC-1, causes Ophthalmo-acromelic (Waardenburg Anophthalmia) syndrome in humans and mice. PLoS Genet. 2011 Jul;7(7):e1002114. doi: 10.1371/journal.pgen.1002114. Epub 2011 Jul 7.
تاريخ المقال
المقال متاح أيضًا باللغة الإنجليزية, الألمانية, إسبانية, الفرنسية, إيطالي, البرتغالية, الهندية, العبرية, العربية ,، و السويدية.
26 Sept 2025 | أحدث إصدار
1 Mar 2014 | نُشر في الأصل
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