thyroid stimulating hormone subunit beta
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ال TSHB gene provides instructions for one piece (subunit) of a hormone called thyroid stimulating hormone (TSH). Thyroid stimulating hormone consists of two subunits called alpha and beta. The TSHB gene provides instructions for making the beta subunit. The alpha and beta subunits are bound together to produce the active form of the hormone. A particular segment of the beta subunit, known as the buckle or seatbelt, wraps around the alpha subunit to form the active hormone. This seatbelt region also helps stabilize the hormone's structure.
Normal function
ال TSHB gene provides instructions for one piece (subunit) of a hormone called thyroid stimulating hormone (TSH). Thyroid stimulating hormone consists of two subunits called alpha and beta. The TSHB gene provides instructions for making the beta subunit. The alpha and beta subunits are bound together to produce the active form of the hormone. A particular segment of the beta subunit, known as the buckle or seatbelt, wraps around the alpha subunit to form the active hormone. This seatbelt region also helps stabilize the hormone's structure.
Thyroid stimulating hormone is made in the pituitary gland, a gland at the base of the brain. This hormone plays an important role in the growth and function of the thyroid gland, a butterfly-shaped tissue in the lower neck. It also stimulates the production of thyroid hormones, which play a critical role in regulating growth, brain development, and the rate of chemical reactions in the body (metabolism). The pituitary gland monitors levels of thyroid hormones. When thyroid hormone levels are too low, the pituitary gland releases thyroid stimulating hormone into the bloodstream. Thyroid stimulating hormone, in turn, signals increased thyroid gland growth and production of thyroid hormones.
Conditions referring to this gene or chromosome
Other names
thyroid stimulating hormone, beta
thyrotropin beta chain precursor
thyrotropin beta subunit
TSH-BETA
TSHB_HUMAN
Related patient information and medicines
Patient information leaflet
اضطرابات الغدة النخامية
This leaflet gives a brief overview of the pituitary gland and the hormones it makes. The pituitary gland is found at the base of the brain and is 'pea-sized'. Men also have prolactin but its function is not understood well. Thyroid-stimulating hormone (TSH) Thyroid gland TSH stimulates the الغدة الدرقية to produce its own hormones,.
Patient information leaflet
فرط نشاط الغدة الدرقية
Hyperthyroidism is an uncommon condition where your thyroid gla... Thyroxine is a body chemical (hormone) made by your thyroid gland. One or both of the following may be measured in a blood sample: Thyroid-stimulating hormone (TSH). This chemical (hormone) is made in the pituitary gland in the brain. أدوية حاصرات بيتا Some people are given a.
Patient information leaflet
اختبارات وظائف الغدة الدرقية
Thyroid function tests are blood tests which help to check the function of your thyroid gland. A thyroid function test is a blood test measuring the levels of the hormones made by your thyroid gland. The test also checks the level of a hormone made by the pituitary gland in your brain, which acts on your thyroid gland. The two hormones, thyroxine.
Patient information leaflet
قصور الغدة الدرقية
If you have an underactive thyroid gland, the condition is called hypothyroidism. In hypothyroidism, there is a reduced level of thyroid hormone in the body. The thyroid gland is located in the neck and produces thyroid hormones. Thyroid الهرمونات are released when the الغدة الدرقية هو stimulated by thyroid stimulating hormone (TSH). This is a.
Patient information leaflet
مشاكل الغدة الدرقية والغدة الجار درقية
This leaflet gives a brief overview of the thyroid and parathyroid glands and the common medical problems which can occur with these. What are the thyroid and parathyroid glands. Both the thyroid and parathyroid glands are endocrine glands. This means they make and release (secrete) hormones. Hormones are chemicals which are produced by the body.
Patient information leaflet
حاصرات بيتا
Beta-blockers are medicines that are used to treat a variety of conditions. Their full correct name is beta-adrenoceptor blocking medicines (or beta-adrenergic blocking agents), but they are commonly just called beta-blockers. For example, they can reduce shak... Overactive thyroid gland. Beta-blockers can help to reduce symptoms such as tremor,.
قراءة إضافية ومراجع
- thyroid stimulating hormone subunit beta; MedlinePlus, National Library of Medicine.
- Deladoey J, Vuissoz JM, Domene HM, Malik N, Gruneiro-Papendieck L, Chiesa A, Heinrich JJ, Mullis PE. Congenital secondary hypothyroidism due to a mutation C105Vfs114X thyrotropin-beta mutation: genetic study of five unrelated families from Switzerland and Argentina. Thyroid. 2003 Jun;13(6):553-9. doi: 10.1089/105072503322238818.
- Medeiros-Neto G, Herodotou DT, Rajan S, Kommareddi S, de Lacerda L, Sandrini R, Boguszewski MC, Hollenberg AN, Radovick S, Wondisford FE. A circulating, biologically inactive thyrotropin caused by a mutation in the beta subunit gene. J Clin Invest. 1996 Mar 1;97(5):1250-6. doi: 10.1172/JCI118540.
- Partsch CJ, Riepe FG, Krone N, Sippell WG, Pohlenz J. Initially elevated TSH and congenital central hypothyroidism due to a homozygous mutation of the TSH beta subunit gene: case report and review of the literature. Exp Clin Endocrinol Diabetes. 2006 May;114(5):227-34. doi: 10.1055/s-2006-924232.
- Pohlenz J, Dumitrescu A, Aumann U, Koch G, Melchior R, Prawitt D, Refetoff S. Congenital secondary hypothyroidism caused by exon skipping due to a homozygous donor splice site mutation in the TSHbeta-subunit gene. J Clin Endocrinol Metab. 2002 Jan;87(1):336-9. doi: 10.1210/jcem.87.1.8154.
- Ramos HE, Labedan I, Carre A, Castanet M, Guemas I, Tron E, Madhi F, Delacourt C, Maciel RM, Polak M. New cases of isolated congenital central hypothyroidism due to homozygous thyrotropin beta gene mutations: a pitfall to neonatal screening. Thyroid. 2010 Jun;20(6):639-45. doi: 10.1089/thy.2009.0462.
- Vuissoz JM, Deladoey J, Buyukgebiz A, Cemeroglu P, Gex G, Gallati S, Mullis PE. New autosomal recessive mutation of the TSH-beta subunit gene causing central isolated hypothyroidism. J Clin Endocrinol Metab. 2001 Sep;86(9):4468-71. doi: 10.1210/jcem.86.9.7876.
تاريخ المقال
المقال متاح أيضًا باللغة الإنجليزية, الألمانية, إسبانية, الفرنسية, إيطالي, البرتغالية, الهندية, العبرية, العربية ,، و السويدية.
٢١ يونيو ٢٠٢٢ | أحدث إصدار
1 Sept 2015 | نُشر في الأصل
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