thyroid stimulating hormone receptor
آخر تحديث 18 Aug 2020
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ال TSHR gene provides instructions for making a protein, known as a receptor, that attaches (binds) to a hormone called thyroid stimulating hormone (TSH). This receptor spans the membrane of certain cells (called follicular cells) in the thyroid gland, a butterfly-shaped tissue in the lower neck. A large part of the receptor sits on the outer surface of the cell (extracellular), and a small portion is retained inside the cell (intracellular). Thyroid stimulating hormone binds to the extracellular portion of the receptor like a key fitting into a lock, activating a series of reactions that control development of the thyroid gland and its functions. Among its functions, the thyroid gland produces iodine-containing hormones (thyroid hormones), which help regulate growth, brain development, and the rate of chemical reactions in the body (metabolism).
Normal function
ال TSHR gene provides instructions for making a protein, known as a receptor, that attaches (binds) to a hormone called thyroid stimulating hormone (TSH). This receptor spans the membrane of certain cells (called follicular cells) in the thyroid gland, a butterfly-shaped tissue in the lower neck. A large part of the receptor sits on the outer surface of the cell (extracellular), and a small portion is retained inside the cell (intracellular). Thyroid stimulating hormone binds to the extracellular portion of the receptor like a key fitting into a lock, activating a series of reactions that control development of the thyroid gland and its functions. Among its functions, the thyroid gland produces iodine-containing hormones (thyroid hormones), which help regulate growth, brain development, and the rate of chemical reactions in the body (metabolism).
Conditions referring to this gene or chromosome
Other names
LGR3
thyrotropin receptor
TSH Receptors
TSHR_HUMAN
Related patient information and medicines
Patient information leaflet
اضطرابات الغدة النخامية
This leaflet gives a brief overview of the pituitary gland and the hormones it makes. The pituitary gland is found at the base of the brain and is 'pea-sized'. Men also have prolactin but its function is not understood well. Thyroid-stimulating hormone (TSH) Thyroid gland TSH stimulates the الغدة الدرقية to produce its own hormones,.
Patient information leaflet
قصور الغدة الدرقية
If you have an underactive thyroid gland, the condition is called hypothyroidism. In hypothyroidism, there is a reduced level of thyroid hormone in the body. The thyroid gland is located in the neck and produces thyroid hormones. Thyroid hormones are released when the thyroid gland is stimulated by thyroid stimulating hormone (TSH). This is a.
Patient information leaflet
هل يمكنني تناول أشواغاندا وعبوة مضخة أوستروجيل معًا؟
Why this happens Ashwagandha is thought to have 'pro-oestrogenic' properties, meaning it may stimulate oestrogen receptors or increase the production of precursors to oestrogen. When used with Hormone Replacement Therapy (HRT) like Oestrogel, this could lead to an additive effect, resulting in higher-than-normal oestrogen ac... Important.
Patient information leaflet
اختبارات وظائف الغدة الدرقية
Thyroid function tests are blood tests which help to check the function of your thyroid gland. A thyroid function test is a blood test measuring the levels of the hormones made by your thyroid gland. The test also checks the level of a hormone made by the pituitary gland in your brain, which acts on your thyroid gland. The two hormones, thyroxine.
Patient information leaflet
مشاكل الغدة الدرقية والغدة الجار درقية
This leaflet gives a brief overview of the thyroid and parathyroid glands and the common medical problems which can occur with these. What are the thyroid and parathyroid glands. Both the thyroid و parathyroid glands are endocrine glands. This means they make and release (secrete) hormones. Hormones are chemicals which are produced by the body.
Patient information leaflet
هل يمكنني تناول الأشواغاندا والمغنيسيوم معًا؟
Important precautions Autoimmune diseases أشواغاندا يمكن أن stimulate the immune system, which may worsen symptoms of autoimmune conditions or interfere with immunosuppressant medications اضطرابات الغدة الدرقية (hyperthyroidism) Ashwagandha may increase thyroid hormone levels; this can be dangerous for people with overactive thyroids or those taking.
قراءة إضافية ومراجع
- thyroid stimulating hormone receptor; MedlinePlus, National Library of Medicine.
- Abramowicz MJ, Duprez L, Parma J, Vassart G, Heinrichs C. Familial congenital hypothyroidism due to inactivating mutation of the thyrotropin receptor causing profound hypoplasia of the thyroid gland. J Clin Invest. 1997 Jun 15;99(12):3018-24. doi: 10.1172/JCI119497.
- Bas VN, Cangul H, Agladioglu SY, Kendall M, Cetinkaya S, Maher ER, Aycan Z. Mild and severe congenital primary hypothyroidism in two patients by thyrotropin receptor (TSHR) gene mutation. J Pediatr Endocrinol Metab. 2012;25(11-12):1153-6. doi: 10.1515/jpem-2012-0211.
- Biebermann H, Schoneberg T, Krude H, Schultz G, Gudermann T, Gruters A. Mutations of the human thyrotropin receptor gene causing thyroid hypoplasia and persistent congenital hypothyroidism. J Clin Endocrinol Metab. 1997 Oct;82(10):3471-80. doi: 10.1210/jcem.82.10.4286.
- Cangul H, Aycan Z, Saglam H, Forman JR, Cetinkaya S, Tarim O, Bober E, Cesur Y, Kurtoglu S, Darendeliler F, Bas V, Eren E, Demir K, Kiraz A, Aydin BK, Karthikeyan A, Kendall M, Boelaert K, Shaw NJ, Kirk J, Hogler W, Barrett TG, Maher ER. TSHR is the main causative locus in autosomal recessively inherited thyroid dysgenesis. J Pediatr Endocrinol Metab. 2012;25(5-6):419-26. doi: 10.1515/jpem-2012-0053.
- Cangul H, Saglam H, Saglam Y, Eren E, Dogan D, Kendall M, Tarim O, Maher ER, Barrett TG. An essential splice site mutation (c.317+1G>A) in the TSHR gene leads to severe thyroid dysgenesis. J Pediatr Endocrinol Metab. 2014 Sep;27(9-10):1021-5. doi: 10.1515/jpem-2014-0048.
- Castro I, Lima L, Seoane R, Lado-Abeal J. Identification and functional characterization of two novel activating thyrotropin receptor mutants in toxic thyroid follicular adenomas. Thyroid. 2009 Jun;19(6):645-9. doi: 10.1089/thy.2009.0002.
- Davies TF, Ando T, Lin RY, Tomer Y, Latif R. Thyrotropin receptor-associated diseases: from adenomata to Graves disease. J Clin Invest. 2005 Aug;115(8):1972-83. doi: 10.1172/JCI26031.
- Gozu H, Avsar M, Bircan R, Sahin S, Ahiskanali R, Gulluoglu B, Deyneli O, Ones T, Narin Y, Akalin S, Cirakoglu B. Does a Leu 512 Arg thyrotropin receptor mutation cause an autonomously functioning papillary carcinoma? Thyroid. 2004 Nov;14(11):975-80. doi: 10.1089/thy.2004.14.975.
- Park SM, Chatterjee VK. Genetics of congenital hypothyroidism. J Med Genet. 2005 May;42(5):379-89. doi: 10.1136/jmg.2004.024158.
- Refetoff S. Resistance to thyrotropin. J Endocrinol Invest. 2003 Aug;26(8):770-9. doi: 10.1007/BF03347364.
- Russo D, Costante G, Bruno R, Sponziello M, Tamburrano G, Dima M, Sacco R, Giacomelli L, Durante C, Filetti S. TSH receptor extracellular region mutations in thyroid functioning nodules: further evidence for the functional role of this region in the receptor activation. Endocrine. 2011 Dec;40(3):492-4. doi: 10.1007/s12020-011-9525-7. Epub 2011 Aug 24. No abstract available.
تاريخ المقال
المقال متاح أيضًا باللغة الإنجليزية, الألمانية, إسبانية, الفرنسية, إيطالي, البرتغالية, الهندية, العبرية, العربية ,، و السويدية.
18 Aug 2020 | أحدث إصدار
1 Sept 2015 | نُشر في الأصل
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