Can I take St John's wort and Sertraline together?

Do not take عشبة القديس يوحنا if you are already taking سيرترالين.

If you are currently taking both, you should contact your GP or pharmacist immediately for advice before stopping either medication, as stopping antidepressants suddenly can also cause side effects.

لماذا يحدث هذا

Both sertraline and St John's wort work by increasing the levels of serotonin in the brain. When used at the same time, they have an 'additive effect', pushing serotonin levels far too high.

Additionally, St John's wort can change how the liver breaks down certain medicines, which can make the levels of sertraline in your blood unpredictable.

You may be experiencing an interaction between St John's wort and sertraline if:

• You feel agitated, restless, or unusually anxious.

• You experience confusion or changes in mental state.

• You notice tremors, muscle twitching, or shaking.

• You have excessive sweating, flushing, or fever.

• You develop a fast or irregular heartbeat.

• You experience diarrhoea or nausea.

• Symptoms start soon after starting, combining, or increasing the dose of either product.

If you have any of the above symptoms, you should:

• Contact your GP or pharmacist immediately for advice.

• Seek urgent medical help if you develop high fever, confusion, severe agitation, or a fast heartbeat.

• Do not stop sertraline suddenly unless advised by a healthcare professional.

• Stop taking St John’s wort and inform your healthcare professional that you have been using it.

• Tell your healthcare professional about all other medicines and supplements you are taking.

متلازمة السيروتونين

Do not take St John's wort and sertraline together. Combining them can cause dangerously high levels of serotonin, leading to a life-threatening condition called متلازمة السيروتونين. Symptoms include shivering, diarrhoea, confusion, and severe muscle stiffness.

Suicidal thoughts and self-harm

Antidepressants like sertraline and St John's wort can increase the risk of suicidal thoughts or self-harm, particularly in the first few weeks of treatment or when the dose is changed. Patients and carers should monitor for any changes in mood or behaviour and seek urgent medical help if these occur.

زيادة خطر النزيف

Sertraline can increase the risk of bleeding, especially if you are taking other medicines that affect blood clotting, such as aspirin, ibuprofen (NSAIDs), or warfarin. Seek medical advice if you notice unusual bruising or bleeding.

التفاعلات الدوائية

St John's wort makes many essential medicines less effective, including the contraceptive pill and blood thinners such as الوارفارين. This can lead to unplanned pregnancy or an increased risk of blood clots.

الكحول

It is best to avoid or strictly limit alcohol while taking these medicines. Combining alcohol with sertraline or St John's Wort can increase drowsiness, dizziness, and impair your coordination. There is also a risk that alcohol may worsen your symptoms of depression or anxiety.

عصير الجريب فروت

تجنب شرب كميات كبيرة من عصير الجريب فروت. يحتوي الجريب فروت على مركبات يمكن أن تزيد من مستويات السيرترالين في دمك، مما قد يزيد من خطر الآثار الجانبية.

الكافيين (القهوة، الشاي، مشروبات الطاقة)

St John's Wort can sometimes increase sensitivity to caffeine, leading to feelings of restlessness, anxiety, or a racing heart. Monitor your intake if you feel jittery.

Foods high in tyramine

While the risk is lower than with older types of antidepressants, some people taking St John's wort may experience a rise in blood pressure if they consume very large amounts of foods high in tyramine (e.g., aged cheeses, cured meats, fermented products). Use these foods in moderation.

Taking multiple medicines? Our مدقق تفاعلات الأدوية helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

إخلاء المسؤولية

هذه المعلومات لأغراض تعليمية عامة فقط ولا ينبغي الاعتماد عليها كبديل للنصيحة الطبية المهنية. استشر دائمًا طبيبك العام أو الصيدلي أو أي متخصص رعاية صحية مؤهل آخر قبل اتخاذ قرارات بشأن أدويتك. قد تختلف الظروف الفردية، ولا يمكن إلا لمتخصص الرعاية الصحية الذي يعرف تاريخك الطبي تقديم إرشادات مخصصة.