بروجستيرون
Cyclogest, Utrogestan
مراجعة من قبل سيد دجانيآخر تحديث بواسطة مايكل ستيوارت، MRPharmSآخر تحديث 9 Jan 2023
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Progesterone is a natural female sex hormone.
Follow carefully the directions your doctor gives to you about taking progesterone. It is prescribed for a selected number of days each month.
Any side-effects are usually mild, but may include feeling sick (nausea), weight gain, and headache.
نظرة سريعة
Progesterone is a female hormone used for various gynaecological problems, including infertility and HRT.
It comes in several forms like capsules, gels, pessaries, and injections, each for different uses.
Your doctor will explain why it has been prescribed for you.
Always follow your doctor's instructions for taking progesterone.
Common side-effects can include feeling sick, headaches, and irregular periods.
Tell your doctor about certain conditions or other medicines you are taking before starting progesterone.
If you have diabetes, you might need to check your blood sugar more often.
About progesterone
نوع الدواء | A progestogen |
يستخدم لـ | A variety of gynaecological problems, including infertility, in early pregnancy, and as part of hormone replacement therapy (HRT) |
يُعرف أيضًا باسم | Crinone® vaginal gel; Cyclogest® pessaries; Lubion® injection; Lutigest® vaginal tablets; Utrogestan® capsules and vaginal capsules |
متوفر كـ | Capsules, vaginal gel, vaginal capsules, pessaries and injection |
Progesterone is a naturally occurring female sex hormone which is essential for the function of the female reproductive system. It is produced in the ovaries during the second half of the menstrual cycle, and also by the placenta during pregnancy. The amount of progesterone a woman produces declines during the menopause.
You will have been prescribed progesterone to supplement your naturally produced progesterone for a reason which your doctor will have explained to you. It works by adjusting the balance of your body's own hormones.
Progesterone is available in a number of formulations that are the subject of this leaflet (gel, injection, capsules, and pessaries). Each formulation is prescribed for a different gynaecological reason.
Progesterone may also be included as an ingredient in a number of combination products used for a variety of medical reasons. These products are not covered by this leaflet and you should read the printed information provided by your doctor and the manufacturer.
Before taking progesterone
Some medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start taking progesterone, it is important that your doctor knows:
إذا كنت حاملاً أو مرضعة.
If you have migraines, asthma, epilepsy or high blood pressure.
If you are having any vaginal bleeding other than your normal monthly period.
If you have ever had a blood clot in your legs or lungs.
إذا كنت تعاني من حالة قلبية.
If you have had any problems with the way your liver or kidneys work.
If you have ever had depression.
إذا كان لديك نسبة عالية من السكر في الدم (داء السكري).
If you have cancer.
If during a pregnancy you had problems such as severe itching, yellowing of your skin or of the whites of your eyes (jaundice), or a skin condition called pemphigoid gestationis.
إذا كنت تعاني من اضطراب دم وراثي نادر يسمى البورفيريا.
إذا كنت قد تعرضت في أي وقت مضى لرد فعل تحسسي تجاه دواء.
إذا كنت تتناول أو تستخدم أي أدوية أخرى. يشمل ذلك أي أدوية تتناولها والتي يمكن شراؤها بدون وصفة طبية، بالإضافة إلى الأدوية العشبية والمكملات الغذائية.
How to take progesterone
Before you start this treatment, read the manufacturer's printed information leaflet from inside your pack. The leaflet will give you more information about the brand of progesterone you have been given. It will also provide a full list of side-effects which you may experience.
Follow carefully the instructions your doctor has given you. Progesterone is usually only used on a number of specified days during a monthly cycle. This may range from 4 to 25 days of a month depending on the reason it has been prescribed for you. If you are unsure about what to do, check again with your doctor.
If you have been prescribed:
Utrogestan® capsules as HRT: these should be taken at bedtime, on an empty stomach. This means that you should not take them with or soon after eating food. Just take them on the days of the month your doctor has told you to. You will also be prescribed an oestrogen-containing HRT medicine to take throughout the month.
Utrogestan vaginal® capsules for fertility treatment: use the applicator and follow the manufacturer's instructions for inserting the capsule high into the vagina. Do not take the capsule by mouth, although if you do swallow it accidentally, it will not harm you. The capsules are usually prescribed during the first three months of pregnancy only.
Lutigest® vaginal tablets for fertility treatment: put one tablet into the end of the applicator and use it to insert the tablet into the vagina following the manufacturer's instructions. Push the plunger to release the tablet. The usual dose is one tablet inserted three times daily starting on the day of egg retrieval. You will need to continue using Lutigest® for 30 days if pregnancy is confirmed. Follow the instructions of your doctor.
Crinone® vaginal gel for fertility treatment: use one 'applicatorful' daily into the vagina. Just use it on the days of the month your doctor has told you to.
Cyclogest® pessaries for menstrual problems: use twice daily on the days of the month your doctor has told you to. Pessaries are generally designed to be inserted into the vagina, but Cyclogest® pessaries are also suitable to be inserted into the back passage, as a suppository. If you are unsure which is the correct way for you to use them, check again with your doctor.
Lubion® injection for fertility treatment: make sure you know how to use this injection. If you are unsure which days to use it, or how much to use, check again with your doctor or clinic.
تحقيق أقصى استفادة من علاجك
Try to keep your regular appointments with your doctor. This is so your doctor can check on your progress. Also, remember to keep any routine appointments for breast screening and cervical smear tests.
If you are having an operation or dental treatment, tell the person carrying out the treatment that you are on progesterone.
If you have diabetes you may need to check your blood glucose more frequently, as progesterone can affect the levels of sugar in your blood. Your doctor will advise you about this.
It is best to avoid smoking and drinking too much alcohol while on progesterone. If you are a smoker and you would like advice on how to quit, speak with your doctor or pharmacist.
If you buy any medicines, check with a pharmacist that they are suitable to take with progesterone. This is because some herbal preparations (such as St John's wort) can interfere with the way it works.
Can progesterone cause problems?
Along with their useful effects, all medicines can cause unwanted side-effects although not everyone experiences them. The table below lists some of the most common ones associated with progesterone. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects often improve over the first few days of taking or using a new medicine, but speak with your doctor or pharmacist if any of the following side-effects continue or become troublesome.
Common progesterone side-effects | ماذا يمكنني أن أفعل إذا واجهت هذا؟ |
الشعور بالغثيان (الغثيان) | Eat simple meals (avoid rich or spicy foods) |
صداع | Ask your pharmacist to recommend a suitable painkiller. If the headaches continue or are unusually severe, speak with your doctor as soon as possible |
Irregular periods, breast tenderness, weight changes, feeling dizzy or sleepy, difficulty sleeping, changes in sexual desire, mood changes, skin rash, acne-like spots, changes in hair growth, swollen feet and ankles (due to fluid retention) | تحدث مع طبيبك إذا أصبحت أي من هذه الأمور مزعجة |
إذا شعرت بأي أعراض أخرى تعتقد أنها قد تكون بسبب هذا الدواء، تحدث مع طبيبك أو الصيدلي.
How to store progesterone
احفظ جميع الأدوية بعيدًا عن متناول ورؤية الأطفال.
احفظه في مكان بارد وجاف، بعيدًا عن الحرارة المباشرة والضوء.
معلومات هامة عن جميع الأدوية
معلومات هامة عن جميع الأدوية
لا تأخذ أبدًا أكثر من الجرعة الموصوفة. إذا كنت تشك في أنك أو شخص آخر قد تناول جرعة زائدة من هذا الدواء، اذهب إلى قسم الحوادث والطوارئ في مستشفى منطقتك. خذ العبوة معك، حتى لو كانت فارغة.
هذا الدواء لك. لا تعطه لأشخاص آخرين حتى لو بدت حالتهم مشابهة لحالتك.
لا تحتفظ بالأدوية منتهية الصلاحية أو غير المرغوب فيها. خذها إلى صيدليتك المحلية التي ستتولى التخلص منها نيابة عنك.
إذا كان لديك أي أسئلة حول هذا الدواء، اسأل الصيدلي الخاص بك.
الإبلاغ عن الآثار الجانبية لدواء أو لقاح
إذا واجهت آثارًا جانبية، يمكنك الإبلاغ عنها عبر الإنترنت من خلال موقع بطاقة صفراء.

غير متأكد من خلط الأدوية؟
تحقق من التفاعلات المحتملة بين الأدوية والمكملات الغذائية والأطعمة قبل تناولها معًا.
الأسئلة الشائعة
Can I use Cyclogest and Utrogestan together for progesterone support?
Each formulation of progesterone (like Cyclogest pessaries and Utrogestan capsules/vaginal capsules) is typically prescribed for a specific gynaecological reason. While they both contain progesterone, your doctor will have prescribed a particular type for your individual needs. You should only use the specific formulation and dosage your doctor has prescribed and follow their instructions carefully. If you have questions about combining or switching formulations, you should check with your doctor.
Does progesterone therapy cause weight gain?
Weight changes are listed as a possible side-effect of progesterone. If you notice weight changes and find them troublesome, you should speak with your doctor for advice.
What is the role of progesterone in the body?
Progesterone is a natural female sex hormone crucial for the female reproductive system. It is produced by the ovaries during the second half of the menstrual cycle and by the placenta during pregnancy. Its levels decrease during menopause. When prescribed as medication, it supplements your body's natural progesterone to adjust your hormone balance for various gynaecological issues, including infertility, early pregnancy support, and as part of hormone replacement therapy (HRT).
Who should not take progesterone, or should use it with extra caution?
You should inform your doctor if you have certain conditions before taking progesterone, as it might not be suitable or may require extra care. These include if you are pregnant or breastfeeding, have migraines, asthma, epilepsy, high blood pressure, a history of blood clots, heart problems, liver or kidney issues, depression, diabetes, cancer, or if you experienced specific problems during a previous pregnancy like severe itching, jaundice, or pemphigoid gestationis. Also mention if you have porphyria or have had an allergic reaction to any medicine in the past.
Are there any specific lifestyle habits I should avoid while taking progesterone?
It is advisable to avoid smoking and excessive alcohol consumption while on progesterone. If you are a smoker and would like to quit, your doctor or pharmacist can offer advice. Additionally, if you purchase any over-the-counter medicines, including herbal remedies like St John's wort, it's important to check with a pharmacist to ensure they won't interfere with your progesterone treatment.
When should I take Utrogestan capsules if prescribed for HRT?
If you have been prescribed Utrogestan capsules for HRT, you should take them at bedtime on an empty stomach. This means you should not take them with or soon after eating food. You should only take them on the specific days of the month your doctor has instructed you to. You will also typically be prescribed an oestrogen-containing HRT medicine to take throughout the month.
قراءة إضافية ومراجع
- Manufacturer's PIL, Cyclogest® 200 mg Pessaries; L.D. Collins & Co. Ltd, The electronic Medicines Compendium. Dated March 2022.
- Manufacturer's PIL, Utrogestan® 100 mg Capsules; Besins Healthcare (UK) Ltd, The electronic Medicines Compendium. Dated February 2022.
- Manufacturer's PIL, Utrogestan Vaginal® 200 mg Capsules; Besins Healthcare (UK) Ltd, The electronic Medicines Compendium. Dated July 2022.
- Manufacturer's PIL, Crinone® 8% Progesterone Vaginal Gel; Merck Serono Ltd, The electronic Medicines Compendium. Dated December 2020.
- Manufacturer's PIL, Lutigest® vaginal tablets; Ferring Pharmaceuticals Ltd, The electronic Medicines Compendium. Dated October 2014.
- الأدوية كاملة BNF الطبعة 89; الجمعية الطبية البريطانية والجمعية الملكية الصيدلانية لبريطانيا العظمى، لندن.
عن المؤلفعرض السيرة الذاتية الكاملة

مايكل ستيوارت، MRPharmS
مدير مراجعة النشرات الطبية – متعاقد، صيدلي
بكالوريوس الصيدلة (مع مرتبة الشرف)، عضو الجمعية الملكية للصيادلة
مايكل هو صيدلي مجتمعي يمارس عمله في منطقة ميدلاندز وجنوب يوركشاير ولديه أكثر من 20 عامًا من الخبرة في تقديم المشورة بشأن الأدوية والحالات الطبية. لديه خلفية قوية في تدريب الرعاية الصحية، حيث قام بإنتاج وتقديم دورات تدريبية لفرق الصيدلة وموظفي دور الرعاية السكنية، بما في ذلك الممرضات. كما ساهم في مجالس استشارية للصيدلة لإدارة الحالات ذات الحدة المنخفضة في المجتمع.
حول المراجع

سيد داجاني
تخرج سلطان دجاني من كلية الصيدلة في لندن عام 1994 وأصبح أصغر عضو منتخب في مجلس الجمعية الملكية للصيدلة منذ تأسيسها في عام 1842.
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المراجعة التالية مستحقة: 8 يوليو 2027
9 Jan 2023 | أحدث إصدار

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