kinesin family member 23
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The KIF23 gene provides instructions for making a protein that is part of the kinesin family of proteins. Many proteins in the kinesin family are essential for transporting materials within cells. Kinesin proteins function like freight trains that transport cargo along a track-like system made from structures called microtubules. Some kinesins also help maintain microtubules. As well as functioning like a track, microtubules make up the structural framework of cells and help cells move.
Normal function
The KIF23 gene provides instructions for making a protein that is part of the kinesin family of proteins. Many proteins in the kinesin family are essential for transporting materials within cells. Kinesin proteins function like freight trains that transport cargo along a track-like system made from structures called microtubules. Some kinesins also help maintain microtubules. As well as functioning like a track, microtubules make up the structural framework of cells and help cells move.
The KIF23 protein plays an important role in cytokinesis, which is the stage during cell division in which dividing cells separate from one another. Specifically, this protein attaches (binds) with the protein produced from the RACGAP1 gene to form a complex called centralspindlin, which is a critical regulator of cytokinesis.
Conditions referring to this gene or chromosome
Other names
CHO1
KNSL5
MKLP-1
MKLP1
Related patient information and medicines
Patient information leaflet
مرض الكلى المتعدد الكيسات
Polycystic kidney disease (PKD) causes many fluid-filled sacs (cysts) إلى develop in the kidneys. The most common type of PKD is an inherited condition called autosomal dominant polycystic kidney disease (ADPKD). With ADPKD, problems commonly do not develop until the age of 30-50, with some people never developing any problems. The two common.
Patient information leaflet
مرض هنتنغتون
Between 5-10 in 100 people with Huntington's disease develop symptoms before they are 20. هذا معروف باسم juvenile Huntington's disease. It can cause more severe symptoms. مرض هنتنغتون هو caused by a defective gene that you inherit from your parents. مرض هنتنغتون هو autosomal dominant condition, meaning you can inherit the.
Patient information leaflet
ضمور العضلات
ضمور العضلات هو inherited (genetic) disorder causing muscle weakness. There are different types of muscular dystrophy, which vary as to how severe they are, ranging from very mild to severe. The different types also vary as to what age they begin. What is muscular dystrophy. Muscular dystrophy (MD) is the name given to a group of.
Patient information leaflet
خلل التوتر العضلي
A dystonia is a lasting or frequently recurring and unwanted (involuntary) muscle contraction. It can affect one or more muscles in the body. Secondary dystonia Secondary means the dystonia has been caused by another condition or by something which has happened to you. It is not caused by your genetic make-up. Some neurological conditions can.
Patient information leaflet
التخطيط للحمل
Women on regular medication, or who have a long-term medical condition, may need to seek medical للنساء الحوامل هي تجنب المشروبات التي تحتوي على الكافيين في الثلث الأول من الحمل، وبعد ذلك يجب ألا تستهلك النساء أكثر من 200 ملغ - ما يعادل حوالي كوبين من القهوة - في اليوم،" يقول بوزهزرا. "تم الإبلاغ عن الكافيين كمسبب للصداع النصفي، لكن كل شخص يختلف. الكافيين يمكن أن يسبب أيضًا to discuss any changes which may need to be made. This is ideally done before pregnancy. There is a summary checklist at the end of the leaflet. Women who are already pregnant may find Diet and lifestyle during pregnancy more help. When should I.
Patient information leaflet
اضطراب تعاطي الكحول
Many people drink alcohol. For some, alcohol is something that they enjoy in moderation. Other people drink alcohol at levels that are likely to lead to physical or mental health problems. Alcohol use disorder means drinking alcohol in a way that causes harm. If you or a family member has alcohol use disorder then treatment and support can be.
قراءة إضافية ومراجع
- kinesin family member 23; MedlinePlus, National Library of Medicine.
- Iolascon A, Andolfo I, Russo R. Congenital dyserythropoietic anemias. Blood. 2020 Sep 10;136(11):1274-1283. doi: 10.1182/blood.2019000948.
- Liljeholm M, Irvine AF, Vikberg AL, Norberg A, Month S, Sandstrom H, Wahlin A, Mishima M, Golovleva I. Congenital dyserythropoietic anemia type III (CDA III) is caused by a mutation in kinesin family member, KIF23. Blood. 2013 Jun 6;121(23):4791-9. doi: 10.1182/blood-2012-10-461392. Epub 2013 Apr 9.
- Mendez M, Moreno-Carralero MI, Peri VL, Camacho-Galan R, Bosch-Benitez JM, Huerta-Aragones J, Sanchez-Calero-Guilarte J, Moreno-Risco MB, Alonso-Dominguez JM, Moran-Jimenez MJ. Congenital dyserythropoietic anemia types Ib, II, and III: novel variants in the CDIN1 gene and functional study of a novel variant in the KIF23 gene. Ann Hematol. 2021 Feb;100(2):353-364. doi: 10.1007/s00277-020-04319-5. Epub 2020 Nov 7.
- Russo R, Iolascon A, Andolfo I, Marra R, Rosato BE. Updates on clinical and laboratory aspects of hereditary dyserythropoietic anemias. Int J Lab Hematol. 2024 Aug;46(4):595-605. doi: 10.1111/ijlh.14307. Epub 2024 May 15.
تاريخ المقال
المقال متاح أيضًا باللغة الإنجليزية, الألمانية, إسبانية, الفرنسية, إيطالي, البرتغالية, الهندية, العبرية, العربية ,، و السويدية.
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