recombination signal binding protein for immunoglobulin kappa J region
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ال RBPJ gene provides instructions for making a protein called RBP-J, which is an integral part of a signaling pathway known as the Notch pathway. Notch signaling controls how certain types of cells develop in the growing embryo, including those that form the bones, heart, muscles, nerves, and blood. Signaling through the Notch pathway stimulates the RBP-J protein to attach (bind) to specific regions of DNA and control the activity of genes that play a role in cellular development.
Normal function
ال RBPJ gene provides instructions for making a protein called RBP-J, which is an integral part of a signaling pathway known as the Notch pathway. Notch signaling controls how certain types of cells develop in the growing embryo, including those that form the bones, heart, muscles, nerves, and blood. Signaling through the Notch pathway stimulates the RBP-J protein to attach (bind) to specific regions of DNA and control the activity of genes that play a role in cellular development.
Conditions referring to this gene or chromosome
Other names
CBF-1
CBF1
H-2K binding factor-2
IGKJRB
IGKJRB1
RBP-J
RBP-J kappa
RBP-JK
RBPJK
RBPSUH
SUH
SUH_HUMAN
Related patient information and medicines
Patient information leaflet
متلازمة غيلان باريه
G... Guillain-Barré syndrome is an autoimmune disease. The immune system normally makes small proteins (antibodies) to attack bacteria, viruses, and other germs. For example, you may need help and support with feeding and breathing until the symptoms ease. Some specific treatments that may be given include one or more of the following:.
Patient information leaflet
الجهاز المناعي
This leaflet gives a brief overview of the جهاز المناعة and how it works. A person with a weak immune system might have difficulty fighting off infections. In autoimmune diseases the body is unable to tell what is its own and what is foreign, so it attacks itself. Autoimmune diseases can attack any part of the body - eg, type 1 diabetes.
Patient information leaflet
فيروس جدري القرود
Antibodies يكون proteins made by our محصنة system during infection. Immunoglobulins Immunoglobulins are antibodies. These are proteins that are made by the body's immune system to fight infection. We can also make treatments for some diseases by getting these antibodies from a number of... Vaccinia immune globulin (VIG) هو immunoglobulin made.
Patient information leaflet
اختبارات الأجسام المضادة والمستضدات
Tests to det... What is the difference between antibodies and antigens. Antibodies are small proteins that circulate in the bloodstream. They are part of the body's defence (immune) system and are sometimes called immunoglobulins. They are made by a type of white blood cell (a B lymphocyte). Antibodies attach to proteins and other chemicals in the.
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مرض بورنهولم
Bornholm disease is an illness which causes flu-like symptoms, together with pain in the chest or tummy (abdomen). Young babies are most at risk of serious complications. Babies may need preventative treatment (immunoglobulin) to help prevent complications. What is Bornholm disease. The recommended treatment is called immunoglobulin. This is given.
Patient information leaflet
الفرفرية قليلة الصفيحات المناعية
These are less often used now than they used to be. الغلوبولين المناعي الوريدي (IVIg) This is an injection of a protein into the bloodstream and has been shown to work well in about 8 in 10 children in increasing the number of platelets. It is not usually used as the first option because it involves an injection. الغلوبولين المناعي المضاد لـ D This is.
قراءة إضافية ومراجع
- recombination signal binding protein for immunoglobulin kappa J region; MedlinePlus, National Library of Medicine.
- Castel D, Mourikis P, Bartels SJ, Brinkman AB, Tajbakhsh S, Stunnenberg HG. Dynamic binding of RBPJ is determined by Notch signaling status. Genes Dev. 2013 May 1;27(9):1059-71. doi: 10.1101/gad.211912.112.
- Hassed SJ, Wiley GB, Wang S, Lee JY, Li S, Xu W, Zhao ZJ, Mulvihill JJ, Robertson J, Warner J, Gaffney PM. RBPJ mutations identified in two families affected by Adams-Oliver syndrome. Am J Hum Genet. 2012 Aug 10;91(2):391-5. doi: 10.1016/j.ajhg.2012.07.005.
- Zanotti S, Canalis E. Notch signaling in skeletal health and disease. Eur J Endocrinol. 2013 May 8;168(6):R95-103. doi: 10.1530/EJE-13-0115. Print 2013 Jun.
تاريخ المقال
المقال متاح أيضًا باللغة الإنجليزية, الألمانية, إسبانية, الفرنسية, إيطالي, البرتغالية, الهندية, العبرية, العربية ,، و السويدية.
٨ سبتمبر ٢٠٢٥ | أحدث إصدار
1 Nov 2015 | نُشر في الأصل
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