Can I take Aspirin and Ezetimibe together?
Drug interaction guide
Originally published 25 Jan 2026
Meets Patient’s editorial guidelines
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There is no known significant interaction between aspirin and ezetimibe. These two medicines are often prescribed together to help prevent heart attacks and strokes.
Why this happens
Aspirin works by making the blood less 'sticky' (antiplatelet), while ezetimibe works by reducing the amount of cholesterol absorbed from your food. They do not interfere with how the body processes each other, nor do they increase each other's side effects.
What you should do
You can safely take these medicines together as prescribed by your doctor. Always follow the specific dosing instructions provided on your prescription labels.
Important precautions
Asthma
Do not take aspirin if you have asthma and have ever had a reaction to aspirin or other non-steroidal anti-inflammatory drugs (NSAIDs), as it can trigger a life-threatening asthma attack.
Pregnancy (third trimester)
Do not take aspirin if you are more than 6 months pregnant, as it can cause serious heart and kidney problems in the unborn baby and lead to complications during delivery.
Children and teenagers under 16
Never give aspirin to children or teenagers under 16 unless specifically prescribed by a doctor, due to the risk of Reye’s syndrome, a rare but life-threatening condition affecting the brain and liver.
Food and drink warnings
Alcohol
Drinking alcohol while taking aspirin can increase the risk of stomach irritation and bleeding. It is best to limit alcohol intake or avoid it if you have a history of stomach issues.
Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
Article also available in English, German, Spanish, French, Italian, Portuguese, Hindi, Hebrew, Arabic, and Swedish.
25 Jan 2026 | Originally published

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