Hyperkalemic periodic paralysis
آخر تحديث 22 أغسطس 2023
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Hyperkalemic periodic paralysis is a condition that causes episodes of extreme muscle weakness or paralysis, usually beginning in infancy or early childhood. Most often, these episodes involve a temporary inability to move muscles in the arms and legs. Episodes tend to increase in frequency until mid-adulthood, after which they occur less frequently in many people with the condition. Factors that can trigger attacks include rest after exercise, potassium-rich foods such as bananas and potatoes, stress, fatigue, alcohol, pregnancy, exposure to hot or cold temperatures, certain medications, and periods without food (fasting). Muscle strength usually returns to normal between attacks, although many affected people continue to experience mild stiffness (myotonia), particularly in muscles of the face and hands.
الوصف
Hyperkalemic periodic paralysis is a condition that causes episodes of extreme muscle weakness or paralysis, usually beginning in infancy or early childhood. Most often, these episodes involve a temporary inability to move muscles in the arms and legs. Episodes tend to increase in frequency until mid-adulthood, after which they occur less frequently in many people with the condition. Factors that can trigger attacks include rest after exercise, potassium-rich foods such as bananas and potatoes, stress, fatigue, alcohol, pregnancy, exposure to hot or cold temperatures, certain medications, and periods without food (fasting). Muscle strength usually returns to normal between attacks, although many affected people continue to experience mild stiffness (myotonia), particularly in muscles of the face and hands.
Most people with hyperkalemic periodic paralysis have increased levels of potassium in their blood (hyperkalemia) during attacks. Hyperkalemia results when the weak or paralyzed muscles release potassium ions into the bloodstream. In other cases, attacks are associated with normal blood potassium levels (normokalemia). Ingesting potassium can trigger attacks in affected individuals, even if blood potassium levels do not go up.
Inheritance patterns
The source lists the following possible inheritance patterns: Autosomal dominant. More than one pattern can apply in different cases.
Related genes
Other names
Adynamia episodica hereditaria
Familial hyperkalemic periodic paralysis
Gamstorp disease
Gamstorp episodic adynamy
HyperKPP
HyperPP
Primary hyperkalemic periodic paralysis
Related patient information and medicines
Patient information leaflet
نقص صوديوم الدم
نقص صوديوم الدم هو a low level of sodium in the blood. Sodium levels in the blood have to be tightly controlled. Too rapid correction of hyponatraemia can cause a condition called central pontine myelinolysis. Symptoms occur 2-4 days after onset and may present with paralysis of all four limbs (quadriplegia). This has been seen more often in those.
Patient information leaflet
متلازمة إعادة التغذية
متلازمة إعادة التغذية was first described in Far East prisoners after the second world war when they developed فشل القلب after starting to eat again after a prolonged period of starvation. What is refeeding syndrome. متلازمة إعادة التغذية is a dangerous and life threatening shift of fluids and body salts (electrolytes) that can occur when.
Patient information leaflet
السنسنة المشقوقة
In most cases of myelomeningocele, surgery can be carried out to close the defect. However, damage to the nervous system will usually already have taken place. The nerve damage can cause a range of symptoms, including weakness (paralysis) of the legs and loss of feeling in the skin of the legs. There may also be problems with passing wee (urine).
Patient information leaflet
التهاب الدماغ
التهاب الدماغ هو inflammation of the brain. It is usually caused by a viral infection. In the UK, the most common virus to cause encephalitis is herpes simplex virus. Symptoms usually start with the common symptoms of a viral infection such as high temperature (fever), headache, muscle... Stiff neck and back. Intolerance of light (photophobia)..
Patient information leaflet
الاضطرابات الجسدية والوظيفية
Sometimes there are no obvious reasons fo... This may be more common in situations where someone has very severe pain but where there is no underlying physical cause for that pain. Functional neurological disorder Previously known as conversion disorder, functional neurological disorder (or FND) is a condition where a person has neurological.
Patient information leaflet
مشاكل العين
Lagophthalmos Lagophthalmos is the inability to close the eyelid... This leads to corneal exposure and dryness. The main cause is facial nerve paralysis. However, it can occur after trauma or eyelid surgery (cicatricial lagophthalmos) or during sleep (nocturnal lagophthalmos). The main cause is Bell's palsy. Bell's palsy Bell's palsy is the most.
قراءة إضافية ومراجع
- Hyperkalemic periodic paralysis; MedlinePlus, National Library of Medicine.
- Cannon SC. An expanding view for the molecular basis of familial periodic paralysis. Neuromuscul Disord. 2002 Aug;12(6):533-43. doi: 10.1016/s0960-8966(02)00007-x.
- Fontaine B. Periodic paralysis. Adv Genet. 2008;63:3-23. doi: 10.1016/S0065-2660(08)01001-8.
- Jurkat-Rott K, Holzherr B, Fauler M, Lehmann-Horn F. Sodium channelopathies of skeletal muscle result from gain or loss of function. Pflugers Arch. 2010 Jul;460(2):239-48. doi: 10.1007/s00424-010-0814-4. Epub 2010 Mar 17.
- Jurkat-Rott K, Lehmann-Horn F. Genotype-phenotype correlation and therapeutic rationale in hyperkalemic periodic paralysis. Neurotherapeutics. 2007 Apr;4(2):216-24. doi: 10.1016/j.nurt.2007.02.001.
- Jurkat-Rott K, Lehmann-Horn F. Paroxysmal muscle weakness: the familial periodic paralyses. J Neurol. 2006 Nov;253(11):1391-8. doi: 10.1007/s00415-006-0339-0. Epub 2006 Nov 30.
- Miller TM, Dias da Silva MR, Miller HA, Kwiecinski H, Mendell JR, Tawil R, McManis P, Griggs RC, Angelini C, Servidei S, Petajan J, Dalakas MC, Ranum LP, Fu YH, Ptacek LJ. Correlating phenotype and genotype in the periodic paralyses. Neurology. 2004 Nov 9;63(9):1647-55. doi: 10.1212/01.wnl.0000143383.91137.00.
- Venance SL, Cannon SC, Fialho D, Fontaine B, Hanna MG, Ptacek LJ, Tristani-Firouzi M, Tawil R, Griggs RC; CINCH investigators. The primary periodic paralyses: diagnosis, pathogenesis and treatment. Brain. 2006 Jan;129(Pt 1):8-17. doi: 10.1093/brain/awh639. Epub 2005 Sep 29.
- Weber F. Hyperkalemic Periodic Paralysis. 2003 Jul 18 [updated 2021 Jul 1]. In: Adam MP, Bick S, Mirzaa GM, Wallace SE, Amemiya A, editors. GeneReviews(R) [Internet]. Seattle (WA): University of Washington, Seattle; 1993-2026. Available from http://www.ncbi.nlm.nih.gov/books/NBK1496/
تاريخ المقال
المقال متاح أيضًا باللغة الإنجليزية, الألمانية, إسبانية, الفرنسية, إيطالي, البرتغالية, الهندية, العبرية, العربية ,، و السويدية.
22 أغسطس 2023 | أحدث إصدار
1 Aug 2013 | نُشر في الأصل
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