Ambrisentan for pulmonary hypertension

About ambrisentan

Ambrisentan is prescribed to treat pulmonary arterial hypertension (PAH). This is a condition where there is too high a blood pressure in the blood vessels that supply the lungs from the heart.

Ambrisentan relaxes the muscle cells in the walls of the blood vessels to your lungs, allowing them to become wider (dilated). This reduces the pressure in these blood vessels and allows blood to flow more easily through them. In turn, this increases the supply of blood to your lungs and improves your ability to do physical activities. It will be prescribed for you by a doctor who is a specialist.

Some medicines are not suitable for people with certain conditions, and sometimes a medicine can only be used if extra care is taken. For these reasons, before you start taking ambrisentan it is important that your doctor knows:

• If you are or could become pregnant, or if you are breastfeeding.

• إذا كان لديك أي مشاكل في طريقة عمل الكبد لديك، أو إذا كان لديك أي مشاكل في طريقة عمل الكلى لديك.

• If you have been told you have a reduced number of red blood cells (anaemia).

• If you have been told you have a condition called idiopathic pulmonary fibrosis (IPF), where there is scarring in your lungs.

• إذا كنت قد تعرضت في أي وقت مضى لرد فعل تحسسي تجاه دواء.

• إذا كنت تتناول أي أدوية أخرى. يشمل ذلك أي أدوية تتناولها والتي يمكن شراؤها بدون وصفة طبية، بالإضافة إلى الأدوية العشبية والمكملات الغذائية.

• Before you start the treatment, read the manufacturer's printed information leaflet from inside the pack. It will give you more information about ambrisentan, and it will also provide you with a full list of the side-effects which you could experience from taking it.

• Take ambrisentan exactly as your doctor tells you to. The usual dose is one 5 mg tablet daily, although your doctor may increase the strength of your tablets to 10 mg if a higher dose is needed. Unless your doctor tells you otherwise, you can generally take your dose at a time of day that suits you. You should, however, try to take each of your doses at a similar time of day, each day.

• Swallow the tablets whole with a drink of water - do not break or chew the tablets. You can take ambrisentan tablets either with or without food.

• إذا نسيت تناول جرعة، فتناولها بمجرد أن تتذكر. إذا لم تتذكر حتى اليوم التالي، فاترك الجرعة المنسية من اليوم السابق وتناول الجرعة المستحقة كالمعتاد. لا تتناول جرعتين في نفس الوقت لتعويض الجرعة الفائتة.
  

• Try to keep all your regular appointments with your doctor. This is so your doctor can check on your progress. You will need to have regular blood tests while on ambrisentan to check that you do not develop anaemia. Your doctor will also want to check that your liver stays healthy. Signs that your liver may not be working properly are feeling sick, a high temperature, dark urine, jaundice, stomach pain, feeling unusually tired, and flu-like symptoms - let your doctor know straightaway if you develop any of these.

• You must avoid getting pregnant while you are taking ambrisentan because it could cause harm to an unborn baby. Make sure you have discussed with your doctor which types of contraception are suitable for you and your partner.

• It is possible that ambrisentan taken long-term reduces fertility in men by lowering the sperm count. Discuss this with your doctor if you have any concerns about it.

• If you are due to have an operation or some other medical treatment, it is important that you tell the person carrying out the treatment that you are taking ambrisentan.

• If you buy any medicines 'over the counter', always check with a pharmacist that they are suitable for you to take with ambrisentan.

Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the more common ones associated with ambrisentan. The best place to find a full list of the side-effects which can be associated with your medicine, is from the manufacturer's printed information leaflet supplied with the medicine. Alternatively, you can find an example of a manufacturer's information leaflet in the reference section below. Speak with your doctor or pharmacist if any of the following continue or become troublesome.

إذا شعرت بأي أعراض أخرى تعتقد أنها قد تكون بسبب الأقراص، تحدث مع طبيبك أو الصيدلي للحصول على مزيد من النصائح.

• احفظ جميع الأدوية بعيدًا عن متناول ورؤية الأطفال.

• احفظه في مكان بارد وجاف، بعيدًا عن الحرارة المباشرة والضوء.