Etravirine for HIV

About etravirine

Etravirine is an antiretroviral medicine. It is used for عدوى فيروس نقص المناعة البشرية (HIV). It slows the progress of HIV infection, but it is not a cure. HIV destroys cells in the body, called CD4 T cells. These cells are a type of white blood cell and are important because they are involved in protecting your body from infection. If left untreated, the HIV infection weakens your immune system so that your body cannot defend itself against bacteria, viruses and other germs. Etravirine slows down the progress of HIV infection by reducing the amount of virus in your body. It does this by stopping the virus from copying (replicating) itself.

Etravirine will be prescribed for you by a doctor who is a specialist. It belongs to a group of antiretroviral medicines known as non-nucleoside reverse transcriptase inhibitors. It is given alongside a number of other antiretroviral medicines, as part of a combination therapy. Taking three or more antiretroviral medicines at the same time is more effective than taking one alone. Taking a combination of different medicines also reduces the risk that the virus will become resistant to any individual medicine. It is vital to take them exactly as prescribed to maintain success and to help to prevent the virus from becoming resistant to the medicines. These medicines are usually taken for life.

Some medicines are not suitable for people with certain conditions, and sometimes a medicine can only be used if extra care is taken. For these reasons, before you start taking etravirine it is important that your doctor knows:

• إذا كنت حاملاً أو مرضعة.

• إذا كان لديك أي مشاكل في كيفية عمل الكبد لديك.

• إذا كنت تعاني من اضطراب دم وراثي نادر يسمى البورفيريا.

• إذا كنت تتناول أي أدوية أخرى. يشمل ذلك أي أدوية يمكن شراؤها بدون وصفة طبية، بالإضافة إلى الأدوية العشبية والمكملات الغذائية.

• إذا كنت قد تعرضت في أي وقت مضى لرد فعل تحسسي تجاه دواء.

• Before you start the treatment, read the manufacturer's printed information leaflet from inside the pack. It will give you more information about etravirine, and it will also provide you with a full list of the side-effects which you could experience from taking it.

• Take etravirine exactly as your doctor tells you to. There are three strengths of tablet available: 200 mg for adults, and 25 mg and 100 mg for older children. The usual adult dose is one 200 mg tablet twice daily. If your child has been prescribed etravirine, your doctor will tell you what dose should be taken. Where possible the two daily doses should be taken 12 hours apart - so, the first dose in the morning and the other in the evening. It is important that etravirine tablets are taken following a meal or after a snack, as this will help your body to absorb the medicine.

• If you have difficulty swallowing tablets, you can mix the tablet into water, providing you then swallow the mixture straightaway.

• If you forget to take a dose, take it as soon as you remember, providing it is within six hours of the time you should have taken it. If it is more than six hours since you should have taken it, leave out the missed dose but remember to take your next dose when it is due. Do not take two doses together to make up for a forgotten dose.

• حافظ على مواعيدك المنتظمة مع طبيبك حتى يمكن متابعة تقدمك. ستحتاج إلى إجراء فحوصات دم منتظمة.

• It is important that you continue to take etravirine and your other antiretroviral treatment regularly. This will help to prevent the HIV from becoming resistant to the medicines you are taking. Even if you miss only a small number of doses, the virus can become resistant to treatment.

• If you develop an infection soon after you start the treatment, let your doctor know. As a result of taking etravirine, your immune system may start fighting an infection which was present before you started the treatment, but which you may not have been aware of.

• اتبع بعناية أي نصيحة يقدمها لك طبيبك بشأن إجراء تغييرات في نمط الحياة لتقليل أي خطر على قلبك والأوعية الدموية. يمكن أن تشمل هذه التغييرات الإقلاع عن التدخين، وتناول الطعام الصحي، وممارسة التمارين الرياضية بانتظام.

• على الرغم من أن العلاج بالأدوية المضادة للفيروسات القهقرية قد يقلل من خطر نقل فيروس نقص المناعة البشرية للآخرين من خلال الاتصال الجنسي، إلا أنه لا يوقفه تمامًا. من المهم أن تستخدم الواقيات الذكرية.

• It is not uncommon for people with HIV to feel low or even depressed, especially soon after the diagnosis has been made and treatment has been started. If you have any feelings of depression, or any distressing thoughts about harming yourself then you should speak with your doctor على الفور.

• بعض الأشخاص الذين تناولوا الأدوية المضادة للفيروسات القهقرية (خاصة لفترة طويلة) قد أصيبوا بحالة تسمى نخر العظام. هذه حالة مرضية تصيب العظام حيث تموت الأنسجة العظمية بسبب انخفاض تدفق الدم إليها. يؤدي ذلك إلى آلام في المفاصل وتيبس، ويمكن أن يسبب صعوبات في الحركة. إذا لاحظت أيًا من هذه الأعراض، تحدث مع طبيبك.

• If you buy any medicines, supplements or herbal remedies 'over the counter', check with a pharmacist that they are suitable to take with etravirine and your other medicines. This is because some medicines interfere with antiretrovirals and can stop them from working properly.

• بعض الأشخاص الذين يتناولون الأدوية المضادة للفيروسات القهقرية يطورون تغييرات في طريقة توزيع الدهون في الجسم. يمكن أن يؤدي ذلك إلى تغييرات في صورة الجسم. سيناقش طبيبك إمكانية حدوث ذلك معك.

• إذا كنت ستخضع لعملية جراحية أو علاج أسنان، أخبر الشخص الذي يقوم بالعلاج بالأدوية التي تتناولها.

• Treatment for HIV is usually lifelong. Continue to take etravirine regularly, even if you feel well. This is to keep your immune system healthy.

Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the most common ones associated with etravirine. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome.

إذا شعرت بأي أعراض أخرى تعتقد أنها قد تكون بسبب الأقراص، تحدث مع طبيبك أو الصيدلي للحصول على مزيد من النصائح.

• احفظ جميع الأدوية بعيدًا عن متناول ورؤية الأطفال.

• Store in a cool, dry place, away from direct heat and light. The bottle contains a desiccant to keep the tablets dry - do not transfer the tablets into any other container.