Exenatide for diabetes

About exenatide

Insulin is a hormone which is made naturally in your body, in the pancreas. It helps to control the levels of sugar (glucose) in your blood. If your body does not make enough insulin, or if it does not use the insulin it makes effectively, this results in the condition called السكري (داء السكري).

People with diabetes need treatment to control the amount of sugar in their blood. This is because good control of blood sugar levels reduces the risk of complications later on. Some people can control the sugar in their blood by making changes to the food they eat but, for other people, medicines are given alongside the changes in diet. Exenatide is one of the medicines that are prescribed for people with داء السكري من النوع 2.

Exenatide works in three ways. It increases the amount of insulin produced by your body which then reduces the level of sugar in your blood. It also reduces the amount of a substance called glucagon being produced by your pancreas. Glucagon causes your liver to produce more sugar, so by reducing the amount of glucagon in your body, this also helps to reduce the levels of sugar in your blood. Exenatide also works on your stomach so that food passes more slowly through it. This means that the sugar from your meals takes longer to get into your blood.

Exenatide is given as an injection just under the surface of the skin. It is administered using a syringe and needle or by using an injection device called a pre-filled pen. It is used in addition to other antidiabetic medicines. There are two types of exenatide injection available. There is a standard-release injection (brand name Byetta®) which is given twice daily, and there is a prolonged-release injection (brand name Bydureon®) which is given once a week.

Some medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start using exenatide it is important that your doctor knows:

• إذا كنتِ حاملاً، تحاولين الإنجاب أو تقومين بالرضاعة الطبيعية.

• If you have a problem with your stomach or digestive system.

• If you have ever had an inflamed pancreas (pancreatitis).

• إذا كان لديك أي مشاكل في طريقة عمل الكلى لديك.

• إذا كنت تتناول أي أدوية أخرى. يشمل ذلك أي أدوية تتناولها والتي يمكن شراؤها بدون وصفة طبية، بالإضافة إلى الأدوية العشبية والمكملات الغذائية.

• إذا كنت قد تعرضت في أي وقت مضى لرد فعل تحسسي تجاه دواء.

• Before you start the treatment, read the manufacturer's printed information leaflet from inside the pack as well as any information you are given by your doctor or diabetes clinic. The manufacturer's leaflet will provide you with a full list of the side-effects which you may experience.

• Use exenatide exactly as your doctor tells you to. Your doctor or diabetes nurse will show you how to inject yourself. Exenatide should be injected into the skin on your upper arms, thigh, or tummy (abdomen). Try to choose a slightly different injection site for each of your injections as this will help to prevent skin problems and difficulties in injecting.

• If you are using Byetta®, you will be advised to inject two doses a day. You should have each injection within the 60-minute period before a main meal, and the two doses should be at least six hours apart. The best way to achieve this is to have your first injection during the hour before your first meal of the day, and the second injection during the hour before your evening meal.

• If you forget to use exenatide before a meal, do not inject it after you have eaten, but instead just wait until your next dose is due.

• If you are using Bydureon®, you will be advised to inject one dose a week, on the same day of each week. Each pre-filled pen provides a single dose. The injection can be given at any time of the day, and it can be given either before or after a meal. If you forget to use the injection on your usual day, use it as soon as you remember and keep to your normal weekly schedule. However, if your next scheduled dose is due within three days, miss out the forgotten dose and take your next dose when it is due.

• It is important that you keep your regular doctor's and clinic appointments. This is so that your progress can be monitored. You will need regular check-ups with an eye clinic and a foot clinic as well as with your doctor and diabetes clinic.

• قد يوصي طبيبك بإجراء اختبار للسكر (الجلوكوز) في دمك أو بولك بانتظام للتأكد من أن مرض السكري لديك تحت السيطرة. سيقوم طبيبك أو ممرض السكري بتعليمك كيفية القيام بذلك.

• إذا كنت قد تلقيت نصيحة من طبيبك بشأن تغييرات في نظامك الغذائي، أو الإقلاع عن التدخين، أو ممارسة التمارين الرياضية بانتظام، فمن المهم أن تتبع النصيحة التي تلقيتها.

• Each time you collect a prescription, check that you have been given the brand and strength of exenatide that you are expecting. If anything looks different from what you have had before, ask your pharmacist to check the prescription for you.

• Make sure you know what it feels like if your blood sugar is low. This is known as hypoglycaemia, or a 'hypo'. Although exenatide is unlikely to cause low blood sugar, other medicines that you are taking for diabetes alongside it may. The first signs of hypoglycaemia are feeling shaky or anxious, sweating, looking pale, feeling hungry, having a feeling that your heart is pounding (palpitations), and feeling dizzy. If this happens, eat something containing sugar, such as dextrose tablets, jelly babies or a sugary drink (non-diet), and then follow this up with a snack such as a sandwich or a banana.

• إذا كنت سائقًا، يجب أن تأخذ حذرك بشكل خاص، حيث قد تتأثر قدرتك على التركيز إذا لم يكن مرض السكري لديك تحت السيطرة الجيدة. قد يُنصح بفحص مستويات السكر في الدم قبل السفر واصطحاب وجبة خفيفة معك في الرحلات الطويلة.

• لا تشرب الكحول، لأنه يمكن أن يؤثر على التحكم في مستوى السكر في الدم. اسأل طبيبك إذا كنت بحاجة إلى مزيد من النصائح حول هذا الموضوع.

• إذا شعرت بالعطش بشكل غير عادي، أو كنت تتبول أكثر من المعتاد، أو شعرت بالتعب الشديد، يجب أن تخبر طبيبك. هذه علامات على أن هناك الكثير من السكر في دمك وقد تحتاج علاجك إلى تعديل.

• استشر طبيبك قبل البدء في أي تمرين بدني جديد، حيث سيكون لذلك تأثير على مستويات السكر في الدم وقد تحتاج إلى فحص مستويات الدم أو البول بشكل أكثر انتظامًا.

• If you are due to have an operation or dental treatment, you should tell the person carrying out the treatment that you have diabetes and give them a list of the medicines you are taking.

• This medicine should not be used during pregnancy. Women and girls of childbearing potential must use effective contraception during treatment and for two months after stopping.

• If you buy any medicines, always check with a pharmacist that they are suitable for you to take. Exenatide can interfere with the way some other medicines are absorbed. Because of this, some medicines should not be taken during the hour before exenatide is given, or during the four hours after it has been given.

• Treatment for diabetes is usually lifelong. Continue with exenatide unless you are told otherwise by your doctor.

Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the most common ones associated with exenatide. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome.

If you experience any other symptoms which you think may be due to the injections, speak with your doctor or pharmacist for further advice.

• احفظ جميع الأدوية بعيدًا عن متناول ورؤية الأطفال.

• Exenatide can be kept for four weeks at room temperature as long as this is below 25°C and it is kept away from direct heat and sunlight. It is, however, best to store unopened packs in a refrigerator. Do not freeze exenatide.

• Byetta® pens must be discarded 30 days after being first used.

• Bydureon® pens are for single use only and should be discarded after first use.