Lisinopril - an ACE inhibitor

About lisinopril

Lisinopril belongs to a class of medicines called angiotensin-converting enzyme inhibitors, or ACE inhibitors. It is prescribed for a number of different reasons. You may have been prescribed it to reduce high blood pressure (hypertension), or to treat heart failure, or to protect your heart and blood vessels from further damage following a heart attack, or to protect your kidneys if you have diabetes. Your doctor will tell you why it has been prescribed for you.

ACE inhibitors like lisinopril prevent your body from creating a hormone known as angiotensin II. They do this by blocking (inhibiting) a chemical called angiotensin-converting enzyme. They widen your blood vessels and help to reduce the amount of water put back into your blood by the kidneys.

These actions help to decrease blood pressure in people who have blood pressure which is higher than normal. Although people with high blood pressure often do not feel unwell, if left untreated, high blood pressure can harm the heart and damage blood vessels, leading to a heart attack or stroke. Lisinopril can be used on its own or alongside other medicines which reduce blood pressure (such as hydrochlorothiazide). Combination brands such as Lisoretic® and Zestoretic® can help to reduce the total number of tablets people with high blood pressure need to take each day.

Heart failure is a condition where your heart does not work as well as it should. Because of this, there may be too much circulating fluid in your blood vessels. Lisinopril helps to reduce this. It also appears to have a protective effect on the heart which slows the progression of the heart failure. Its protective action also helps to reduce the risk of heart, kidney or blood vessel problems in people who are at risk of these.

Some medicines are not suitable for people with certain conditions, and sometimes a medicine can only be used if extra care is taken. For these reasons, before you start taking lisinopril it is important that your doctor knows:

• إذا كنت حاملاً أو مرضعة.

• إذا كنت تواجه مشاكل في طريقة عمل كليتيك.

• إذا كنت تعاني من نقص في السوائل في الجسم (الجفاف) - على سبيل المثال، إذا كنت قد أصبت بالإسهال أو المرض مؤخرًا.

• إذا قيل لك أن لديك تراكمًا للترسبات الدهنية على جدران شرايينك، وهي حالة تُسمى تصلب الشرايين.

• إذا كنت تعاني من نوع معين من ضعف الدورة الدموية يسمى مرض الشرايين المحيطية.

• إذا كنت تعاني من مرض الأوعية الدموية الكولاجينية؛ يشمل ذلك حالات مثل الذئبة الحمامية الجهازية (SLE) وتصلب الجلد.

• If you have been told you have heart muscle disease (cardiomyopathy) or narrowing of the main blood vessel from your heart (aortic stenosis).

• If you have been told you have a high level of potassium in your blood.

• إذا كنت قد تعرضت في أي وقت مضى لرد فعل حيث يتورم وجهك أو لسانك أو حلقك (وذمة وعائية).

• إذا كنت تتلقى علاجًا لإزالة التحسس للحماية من لسعات النحل والدبابير.

• إذا كنت تتلقى علاج غسيل الكلى، أو علاج لإزالة الكوليسترول من دمك بواسطة جهاز (فصل الدهون منخفضة الكثافة).

• إذا كنت تتناول أي أدوية أخرى. يشمل ذلك أي أدوية تتناولها والتي يمكن شراؤها بدون وصفة طبية، بالإضافة إلى الأدوية العشبية والمكملات الغذائية.

• If you have ever had an allergic or unusual reaction to any other ACE inhibitor (such as captopril, ramipril or enalapril), or to any other medicine.

• Before you start the treatment, read the manufacturer's printed information leaflet from inside the pack. It will give you more information about lisinopril and will provide you with a full list of side-effects which you may experience from taking it.

• Take the tablets exactly as your doctor tells you to. Lisinopril is taken once daily. There are several different strengths of tablet available (2.5 mg, 5 mg, 10 mg and 20 mg) - the strength of your tablets will depend upon the reason for you taking them.

• Your doctor is likely to advise you to take your very first dose at bedtime. This is because the first dose can make you feel dizzy.

• After the first dose, you can take lisinopril at a time of day you find easy to remember. For most people this will be in the morning. Try to take your doses at the same time of day each day as this will help you to remember to take your doses regularly. You can take lisinopril tablets either with or without food. It is best to swallow the tablet with a drink of water.

• إذا نسيت تناول جرعة، فتناولها بمجرد أن تتذكر. إذا لم تتذكر حتى اليوم التالي، فاترك الجرعة المنسية من اليوم السابق وتناول الجرعة المستحقة كالمعتاد. لا تتناول جرعتين في نفس الوقت لتعويض الجرعة الفائتة.

• Try to keep your regular appointments with your doctor. This is so your progress can be monitored. Your doctor may want you to have some blood tests from time to time to check that your kidneys are working well.

• It is very important that you follow any dietary and lifestyle advice that you are given by your doctor. This may include advice about eating a healthy diet, not smoking, and taking regular exercise.

• If you buy any medicines, check with a pharmacist that they are suitable to take with lisinopril. This is because some medicines (such as anti-inflammatory painkillers and indigestion remedies) could interfere with your treatment.

• It is likely that your doctor will advise that you do not use salt substitutes while you are taking lisinopril. These products have a high content of potassium which could be harmful for you.

• If you drink alcohol, ask your doctor for advice about drinking alcohol while you are on lisinopril. Alcoholic drinks can make you feel light-headed or dizzy, and they may not be advisable for you.

• If you are having an operation or dental treatment, tell the person carrying out the treatment that you are taking lisinopril tablets. This is because some anaesthetics could cause your blood pressure to drop too low.

• Treatment with lisinopril is often long-term, although it is taken for short periods (up to six weeks) following a heart attack. Continue to take the tablets until you are advised otherwise.

Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the most common ones associated with lisinopril. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome.

إذا شعرت بأي أعراض أخرى تعتقد أنها قد تكون بسبب الأقراص، تحدث مع طبيبك أو الصيدلي للحصول على مزيد من النصائح.

• احفظ جميع الأدوية بعيدًا عن متناول ورؤية الأطفال.

• احفظه في مكان بارد وجاف، بعيدًا عن الحرارة المباشرة والضوء.