Zafirlukast for asthma
Accolate
مراجعة من قبل Sid Dajaniآخر تحديث بواسطة Michael Stewart, MRPharmSLast updated 3 Sept 2024
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Clinical author's note
مايكل ستيوارت 12/9/2018: Accolate® tablets were discontinued in the UK in March 2018. At the time of review there are no branded or generic products containing zafirlukast available in the UK. Zafirlukast may still be available in other countries. This medicine leaflet is based on medical information available in the UK at the time of writing and is left here for reference purposes. Please also refer to the manufacturer's information supplied with your medicine.
Take zafirlukast twice daily, one tablet in the morning and one in the evening.
Your doctor will prescribe a reliever inhaler for you to use in case you have an asthma attack. Make sure that you keep it with you all the time.
The most common side-effects are high temperature (fever) and frequent sore throats and infections.
At a glance
Zafirlukast is a medicine used to treat asthma in adults and children over 12 years old.
It works by blocking chemicals called leukotrienes that cause inflammation in the airways.
You should take one tablet in the morning and one in the evening, on an empty stomach.
Zafirlukast does not provide immediate relief for an asthma attack.
Tell your doctor if your asthma symptoms worsen or if you need to use your reliever inhaler more often.
Potential side-effects include fever, sore throat, headache, nausea, and stomach pain.
Seek medical help if you experience jaundice or flu-like symptoms with tingling, numbness, or breathing difficulties.
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تابع القراءة أدناه
About zafirlukast
نوع الدواء | A leukotriene receptor antagonist |
يستخدم لـ | Asthma (for adults and for children aged over 12 years) |
يُعرف أيضًا باسم | Accolate® (discontinued in UK) |
متوفر كـ | أقراص |
الربو is a common condition caused by inflammation in the smaller airways of the lungs. The inflammation irritates the muscles around the airways and causes them to constrict. This causes your airways to narrow. It is then more difficult for air to get in and out of your lungs. This causes the typical symptoms of wheeze, chest tightness and shortness of breath. The inflammation also causes the lining of your airways to make extra mucus which causes coughing.
Asthma symptoms can flare up from time to time and there may be no apparent reason why. However, some people find that symptoms are made worse by triggers such as exercise and pollen. These things cause your body to produce chemical substances called leukotrienes, which cause the inflammation. Zafirlukast helps control the symptoms of asthma by blocking the effects of these leukotrienes.
Before taking zafirlukast
العودة إلى المحتوياتSome medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start taking zafirlukast it is important that your doctor knows:
إذا كنتِ حاملاً، تحاولين الإنجاب أو تقومين بالرضاعة الطبيعية.
إذا كان لديك أي مشاكل في طريقة عمل الكبد لديك، أو أي مشاكل في طريقة عمل الكلى لديك.
إذا كنت تتناول أو تستخدم أي أدوية أخرى. يشمل ذلك أي أدوية تتناولها والتي يمكن شراؤها بدون وصفة طبية، بالإضافة إلى الأدوية العشبية والمكملات الغذائية.
إذا كنت قد تعرضت في أي وقت مضى لرد فعل تحسسي تجاه دواء.
تابع القراءة أدناه
How to take zafirlukast
العودة إلى المحتوياتBefore you start the treatment, read the manufacturer's printed information leaflet from inside the pack. It will give you more information about zafirlukast and will provide you with a full list of the side-effects which you could experience from taking it.
Take zafirlukast exactly as your doctor tells you to. The usual dose is one tablet in the morning and one in the evening.
Swallow the tablet with a drink of water. You should take it 'on an empty stomach', which means that you should take the tablet about an hour before a meal, or wait until two hours afterwards. This is because your body absorbs less zafirlukast after a meal, which means the medicine is less effective.
Take zafirlukast regularly every day, even if your asthma is well controlled. Try not to miss any of your doses but if you do forget, take it as soon as you remember. If when you remember, it is almost time to take your next dose then skip the missed dose and take your next dose when it is due. Do not take two doses together to make up for a forgotten dose.
تحقيق أقصى استفادة من علاجك
العودة إلى المحتوياتTry to keep your regular appointments with your doctor. This is so your doctor can check on your progress. Also, your doctor may want you to have blood tests from time to time to check on the way your liver is working.
Zafirlukast will not give you immediate relief if you are having an asthma attack. Your doctor will prescribe a reliever inhaler for you to use if this happens. Make sure that you keep it with you all the time in case you need to use it.
If you find that your asthma symptoms are getting worse, or that you need to use the reliever inhaler more regularly than usual, please contact your doctor or nurse for advice straightaway.
Do not smoke. Smoking causes severe irritation and damage to the lungs. It will make your condition worse and will reduce the beneficial effects of your medication.
If you buy any medicines, check with a pharmacist that they are suitable for you to take. Some anti-inflammatory painkillers and aspirin can make asthma symptoms worse in some people.
تابع القراءة أدناه
Can zafirlukast cause problems?
العودة إلى المحتوياتAlong with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains the most common ones associated with zafirlukast. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome.
Very common zafirlukast side-effects (these affect more than 1 in 10 people) | ماذا يمكنني أن أفعل إذا واجهت هذا؟ |
High temperature (fever), sore throat and chest infections | إذا كان الأمر مزعجًا، تحدث مع طبيبك |
Common zafirlukast side-effects (these affect fewer than 1 in 10 people) | ماذا يمكنني أن أفعل إذا واجهت هذا؟ |
الشعور بالغثيان (الدوار) أو التقيؤ (القيء)، ألم في البطن (المعدة) | Stick to simple meals and drink plenty of water. Speak with your doctor if this continues |
صداع، آلام العضلات والأوجاع | Ask your pharmacist to recommend a suitable painkiller if troublesome |
مهم: if you get any of the following symptoms, you should let your doctor know straightaway so that you can have a check-up:
Constantly feeling or being sick, stomach pain, yellowing of your skin or the whites of your eyes (jaundice) and feeling generally unwell. These can be signs of a problem with your liver.
Flu-like symptoms, tingling feelings or numbness in your arms or legs, difficulties with breathing, and skin rash. These can be a sign of a very rare but serious disorder called Churg-Strauss syndrome.
إذا شعرت بأي أعراض أخرى تعتقد أنها قد تكون بسبب الأقراص، يرجى التحدث مع طبيبك أو الصيدلي للحصول على مزيد من النصائح.
How to store zafirlukast
العودة إلى المحتوياتاحفظ جميع الأدوية بعيدًا عن متناول ورؤية الأطفال.
احفظه في مكان بارد وجاف، بعيدًا عن الحرارة المباشرة والضوء.
معلومات هامة عن جميع الأدوية
العودة إلى المحتوياتمعلومات هامة عن جميع الأدوية
لا تأخذ أبدًا أكثر من الجرعة الموصوفة. إذا كنت تشك في أنك أو شخص آخر قد تناول جرعة زائدة من هذا الدواء، اذهب إلى قسم الحوادث والطوارئ في مستشفى منطقتك. خذ العبوة معك، حتى لو كانت فارغة.
إذا كنت ستخضع لعملية جراحية أو أي علاج للأسنان، أخبر الشخص الذي يقوم بالعلاج بالأدوية التي تتناولها.
هذا الدواء لك. لا تعطه لأشخاص آخرين حتى لو بدت حالتهم مشابهة لحالتك.
لا تحتفظ بالأدوية منتهية الصلاحية أو غير المرغوب فيها. خذها إلى صيدليتك المحلية التي ستتولى التخلص منها نيابة عنك.
إذا كان لديك أي أسئلة حول هذا الدواء، اسأل الصيدلي الخاص بك.
الإبلاغ عن الآثار الجانبية لدواء أو لقاح
إذا واجهت آثارًا جانبية، يمكنك الإبلاغ عنها عبر الإنترنت من خلال Yellow Card website.

غير متأكد من خلط الأدوية؟
تحقق من التفاعلات المحتملة بين الأدوية والمكملات الغذائية والأطعمة قبل تناولها معًا.
الأسئلة الشائعة
How does zafirlukast help with asthma compared to other treatments?
Zafirlukast works by blocking the effects of chemical substances called leukotrienes, which are produced by your body in response to triggers like exercise or pollen. These leukotrienes cause inflammation, narrow the airways, and lead to asthma symptoms like wheezing and chest tightness. By blocking them, zafirlukast helps control these symptoms.
Can I take zafirlukast if I'm taking other medications, including over-the-counter ones?
You should tell your doctor about all medicines you are taking, including those available without a prescription, as well as any herbal or complementary medicines. This is important because some medicines can interact with zafirlukast, making it less effective or increasing the risk of side-effects.
What should I do if my asthma symptoms aren't improving or get worse while taking zafirlukast?
Zafirlukast will not provide immediate relief during an asthma attack. If you find your asthma symptoms are getting worse, or if you need to use your reliever inhaler more frequently than usual, you should contact your doctor or nurse for advice immediately.
Is there anything I should avoid eating or drinking when taking zafirlukast?
You should take zafirlukast on an empty stomach, which means about an hour before a meal or two hours after a meal. This is because food can reduce how much zafirlukast your body absorbs, making the medicine less effective.
Can zafirlukast affect my liver, and if so, what symptoms should I watch out for?
Yes, zafirlukast can potentially affect your liver. You should contact your doctor straight away if you experience symptoms like constantly feeling or being sick, stomach pain, yellowing of your skin or the whites of your eyes (jaundice), and generally feeling unwell. These could be signs of a liver problem that needs checking.
What is Churg-Strauss syndrome and what are its symptoms?
Churg-Strauss syndrome is a very rare but serious disorder that can be associated with zafirlukast. Symptoms to watch out for include flu-like symptoms, tingling feelings or numbness in your arms or legs, difficulties with breathing, and a skin rash. If you experience any of these, you should let your doctor know immediately.
قراءة إضافية ومراجع
- الأدوية كاملة BNF الطبعة 89; الجمعية الطبية البريطانية والجمعية الملكية الصيدلانية لبريطانيا العظمى، لندن.
تابع القراءة أدناه
About the authorView full bio

مايكل ستيوارت، MRPharmS
Medicine Leaflet Review Manager – Contractor, Pharmacist
BPharm (Hons), MRPharmS
Michael is a community pharmacist practicing in the Midlands and South Yorkshire with more than 20 years’ experience advising on medicines and medical conditions. He has a strong background in healthcare training, having produced and delivered training courses for pharmacy teams and staff of residential care settings, including nurses. He has also contributed to pharmacy advisory boards for the management of low acuity conditions in the community.
About the reviewer

سيد داجاني
Sultan Dajani qualified at the London School of Pharmacy in 1994 and became the youngest elected member of the Royal Pharmaceutical Society council since its founding in 1842.
تاريخ المقال
تمت كتابة المعلومات على هذه الصفحة ومراجعتها من قبل أطباء مؤهلين.
Next review due: 3 Sept 2027
3 Sept 2024 | أحدث إصدار

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