Doxycycline tablets and capsules
Periostat, Vibramycin-D
مراجعة من قبل الدكتور كولين تايدي، MRCGPآخر تحديث بواسطة Michael Stewart, MRPharmSLast updated 5 May 2025
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Take doxycycline with plenty of water. Stand or sit up to take your doses - this will stop the capsules/tablets from causing any irritation to your throat.
Make sure you continue to take the medicine until you finish the full course prescribed.
Do not take indigestion remedies, or supplements containing iron, magnesium, or zinc at the same time as doxycycline as they stop it from working properly.
The most common side effects of doxycycline are diarrhoea, upset stomach, stomach pain, and headache.
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تابع القراءة أدناه
About doxycycline
نوع الدواء | A tetracycline antibiotic |
يستخدم لـ | Bacterial infections; to prevent malaria. |
تُعرف أيضًا باسم (المملكة المتحدة) | Efracea®, Periostat®, Vibramycin-D® |
تُعرف أيضًا في (الولايات المتحدة الأمريكية) | Acticlate®, Doryx®, Mondoxyne®, Monodox®, Okebo®, Oracea®, Targadox®, Vibramycin® |
متوفر كـ | Capsules, modified-release capsules, dispersible tablets; oral liquid medicine (USA) |
What is doxycycline used for?
العودة إلى المحتوياتDoxycycline is a type of antibiotic that is used to treat a number of different types of infection, including chest infections, some skin conditions, الأمراض المنقولة جنسيًا, and infections in or around the mouth.
Doxycycline is also used to prevent people from getting الملاريا when they travel to countries where malaria occurs.
Although doxycycline can only be obtained on a prescription from a doctor, it is not prescribable on the NHS to prevent malaria. This means that you will be given a private (non-NHS) prescription and you will be asked to pay the full price for the tablets/capsules if you are taking it for this reason.
تابع القراءة أدناه
Doxycycline side effects
العودة إلى المحتوياتCommon side effects of doxycycline are:
Upset stomach.
عسر الهضم.
Tummy (abdominal) pain.
الإسهال.
الصداع.
آلام وأوجاع.
Yeast infection (thrush).
جفاف الفم.
القلق.
زيادة التعرق.
You will find a full list in the manufacturer's information leaflet supplied with your medicine. Speak with your doctor or pharmacist if any of these side effects continue or become troublesome.
How to manage doxycycline side effects
العودة إلى المحتوياتDoxycycline side effects | ماذا يمكنني أن أفعل إذا واجهت هذا؟ |
Stomach upset, indigestion, tummy pain | Stick to simple foods - avoid fatty or spicy meals. Take your doses after a meal or with a snack |
إسهال | Drink plenty of water to replace lost fluids. If this continues or is severe, speak with a doctor |
الصداع، وآلام أخرى | Drink plenty of water and ask a pharmacist to recommend a suitable painkiller. If the aches continue, let your doctor know |
A yeast infection which causes redness and itchiness in the mouth or vagina | Speak with a doctor or pharmacist for advice |
Dry mouth, throat irritation | Remember to take your doses with a large glass of water while you are standing or sitting upright |
Feeling anxious, increased sweating | If troublesome, speak with a doctor |
مهم: doxycycline can occasionally cause allergic reactions, such as a skin rash, swollen lips or tongue and difficulty breathing. Seek medical attention as soon as possible if this happens to you.
Remember that doxycycline may make your skin more sensitive to sunlight than usual, causing rash-like symptoms. Use a sun cream with a high sun protection factor on bright days and use a moisturiser to soothe irritated skin.
In rare cases, treatment with tetracycline antibiotics can cause an increase in blood pressure inside the skull. This can cause symptoms such as headache, being sick (vomiting) and vision problems such as blurred or double vision or loss of vision. If this happens to you, seek medical attention and do not take any more of this medicine.
If you experience any other symptoms which you think may be due to the medicine, discuss them with your doctor or pharmacist who will be able to advise you further.
تابع القراءة أدناه
Who should not take doxycycline?
العودة إلى المحتوياتSome medicines are not suitable for people with certain conditions. Before starting doxycycline it is important that your doctor or pharmacist knows:
إذا كنتِ حاملاً، تحاولين الإنجاب أو تقومين بالرضاعة الطبيعية.
إذا كان لديك أي مشاكل في طريقة عمل الكبد لديك، أو إذا كان لديك أي مشاكل في طريقة عمل الكلى لديك.
If you have an inflammatory condition called systemic lupus erythematosus (also called lupus, or SLE).
إذا كنت تعاني من حالة تسبب ضعف العضلات، تُسمى الوهن العضلي الوبيل.
إذا كنت تتناول أي أدوية أخرى. يشمل ذلك أي أدوية يمكن شراؤها بدون وصفة طبية، بالإضافة إلى الأدوية العشبية والمكملات الغذائية.
إذا كنت قد تعرضت في أي وقت مضى لرد فعل تحسسي تجاه دواء.
How to take doxycycline
العودة إلى المحتوياتRead the leaflet in the pack before starting doxycycline. It explains how to take it and lists possible side effects.
Take doxycycline exactly as your doctor tells you. It is usually one dose a day however some people will be prescribed two. For mouth ulcers you may be asked to take four doses a day.
If taking capsules, you must swallow these whole with a glass of water during mealtime. Sit or stand while taking it, and do not take right before bed to avoid throat irritation.
If you have been given dispersible tablets (Vibramycin-D®), you should stir these into a small glass of water to take them. Rinse the solution around your mouth for 2-3 minutes, and then spit it out.
إذا نسيت تناول جرعة، فتناولها بمجرد أن تتذكر. حاول تناول العدد الصحيح من الجرعات كل يوم ولكن لا تتناول جرعتين في نفس الوقت لتعويض الجرعة الفائتة.
Depending on what you are being treated for, your course of treatment could last from a week, to several months. Keep taking doxycycline until the course is finished unless you are told to stop sooner by a doctor.
تحقيق أقصى استفادة من علاجك
العودة إلى المحتوياتAvoid taking antacids or supplements with iron, magnesium, or zinc within 2 hours before or after doxycycline, as they can make it less effective.
Doxycycline may cause your skin to become more sensitive to sunlight than usual. Avoid strong sunlight and do not use sunbeds. Use a sun cream with a high sun protection factor on bright days, even when it is cloudy.
This antibiotic may stop the oral typhoid vaccine from working. If you are having any vaccinations, make sure the person treating you knows that you are taking this medicine.
You will be prescribed a brand of doxycycline that is appropriate for your need, as not all brands are suitable for all of these indications.
إذاnformation for protection against malaria
If you are taking doxycycline to protect against malaria, you must start taking it 1-2 days before you travel. This is to ensure there is sufficient medicine in your bloodstream to give you the required protection. You should continue to take it throughout your stay and for a further four weeks after you have left the area.
If you feel ill or develop a high temperature (fever) or flu-like symptoms while you are travelling or within one year (especially if it is within three months) of returning home, you should see your doctor straightaway. This is important, even if you have taken your antimalarial tablets correctly.
Doxycycline will help reduce the risk of you getting malaria, but it is also important that you take the following precautions against being bitten by mosquitoes:
Cover up bare areas of your arms and legs with long-sleeved, loose-fitting clothing, long trousers and socks. This is especially important if you are outside after sunset, as this is when mosquitoes feed.
Use an effective insect repellent spray on your clothing and any area of your skin which is bare. If you are also using a sunscreen, apply the sunscreen first and the insect repellent afterwards.
Spray the room with an insecticide each evening a couple of hours before you go to bed. Check your sleeping areas for mosquitoes - pay particular attention to furniture and areas under your bed where insects can hide.
If you are sleeping in an unscreened room, use a mosquito net impregnated with an insecticide.
How to store doxycycline
العودة إلى المحتوياتاحفظ جميع الأدوية بعيدًا عن متناول ورؤية الأطفال.
احفظه في مكان بارد وجاف، بعيدًا عن الحرارة المباشرة والضوء.
معلومات هامة عن جميع الأدوية
العودة إلى المحتوياتمعلومات هامة عن جميع الأدوية
لا تأخذ أبدًا أكثر من الجرعة الموصوفة. إذا كنت تشك في أنك أو شخص آخر قد تناول جرعة زائدة من هذا الدواء، اذهب إلى قسم الحوادث والطوارئ في مستشفى منطقتك. خذ العبوة معك، حتى لو كانت فارغة.
إذا كنت ستخضع لعملية جراحية أو أي علاج للأسنان، أخبر الشخص الذي يقوم بالعلاج بالأدوية التي تتناولها.
هذا الدواء لك. لا تعطه لأشخاص آخرين حتى لو بدت حالتهم مشابهة لحالتك.
لا تحتفظ بالأدوية منتهية الصلاحية أو غير المرغوب فيها. خذها إلى صيدليتك المحلية التي ستتولى التخلص منها نيابة عنك.
إذا كان لديك أي أسئلة حول هذا الدواء، اسأل الصيدلي الخاص بك.
الإبلاغ عن الآثار الجانبية لدواء أو لقاح
إذا واجهت آثارًا جانبية، يمكنك الإبلاغ عنها عبر الإنترنت من خلال Yellow Card website.
الأسئلة الشائعة
العودة إلى المحتوياتHow long does doxycycline take to work?
Doxycycline usually starts working within 24 to 48 hours. Most people notice improvement in their symptoms after 2 to 3 days, but you should keep taking the medicine for the full course prescribed, even if you feel better.
Can you drink alcohol with doxycycline?
Yes, you can drink alcohol in moderation while taking doxycycline as alcohol does not stop doxycycline from working. However, drinking too much can increase side effects such as upset stomach, dizziness, or dehydration. For best results limit your alcohol intake until you finish your course.
Is doxycycline safe to take during pregnancy?
No, doxycycline is generally not safe to take during pregnancy. It can affect the development of a baby’s bones and teeth, especially in the second and third trimesters. Always let your doctor know if you are pregnant or planning to become pregnant so you can be prescribed a safer antibiotic.
Does doxycycline make you tired?
Doxycycline can make some people feel tired but it is not a common side effect. If tiredness is severe or doesn't go away, speak to your doctor.
How long does doxycycline stay in your system?
Doxycycline has a half-life of about 18-22 hours, which means it takes roughly 1-2 days for most of it to leave your system after your last dose. However, trace amounts can stay for a few days longer. It is usually fully cleared within 5 days.

غير متأكد من خلط الأدوية؟
تحقق من التفاعلات المحتملة بين الأدوية والمكملات الغذائية والأطعمة قبل تناولها معًا.
قراءة إضافية ومراجع
- Manufacturer's PIL, Doxycycline 50 mg and 100 mg capsules; Sovereign Medical, The electronic Medicines Compendium. Dated March 2024.
- Manufacturer's PIL, Vibramycin-D Dispersible Tablets 100 mg; Pfizer Ltd, The electronic Medicines Compendium. Dated December 2023.
تابع القراءة أدناه
About the author

مايكل ستيوارت، MRPharmS
Medicine Leaflet Review Manager – Contractor, Pharmacist
BPharm (Hons), MRPharmS
Michael is a community pharmacist practicing in the Midlands and South Yorkshire with more than 20 years’ experience advising on medicines and medical conditions. He has a strong background in healthcare training, having produced and delivered training courses for pharmacy teams and staff of residential care settings, including nurses. He has also contributed to pharmacy advisory boards for the management of low acuity conditions in the community.
About the reviewerView full bio

الدكتور كولين تايدي، MRCGP
General Practitioner, Medical Author
MBBS, MRCGP, MRCP (Paediatrics), DCH
Dr Colin Tidy is an NHS Doctor, based in Oxfordshire.
تاريخ المقال
تمت كتابة المعلومات على هذه الصفحة ومراجعتها من قبل أطباء مؤهلين.
Next review due: 5 May 2028
5 May 2025 | أحدث إصدار

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