Isosorbide mononitrate
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مراجعة من قبل Sid Dajaniآخر تحديث بواسطة Michael Stewart, MRPharmSLast updated 20 أكتوبر 2024
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Isosorbide mononitrate helps to prevent angina chest pain from developing.
It is not suitable to take to treat an angina attack - you should always carry with you a short-acting nitrate, such as glyceryl trinitrate (GTN), for if you get angina pain.
The most common side-effect is headache. This should pass after a few days.
At a glance
Isosorbide mononitrate is a medicine used to prevent angina chest pain and treat heart failure.
It works by relaxing and widening blood vessels to improve blood flow to the heart and reduce strain.
Doses are taken once, two, or three times daily depending on the type and doctor's instructions.
Do not chew or crush modified-release tablets or capsules.
This medicine is not for treating an angina attack; use your prescribed short-acting nitrate for that.
Common side-effects include headache, dizziness, tiredness, fast heartbeat, and flushing.
Avoid alcohol while taking this medicine as it can increase side-effects.
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تابع القراءة أدناه
About isosorbide mononitrate
نوع الدواء | A nitrate |
يستخدم لـ | Angina prevention; heart failure |
يُعرف أيضًا باسم | Carmil® XL, Chemydur® XL, Elantan® LA, Imdur®, Isib® XL, Ismo®, Isodur® XL, Isotard® XL, Medomon® XL, Modisal® XL, Monomax® SR, Monomil® XL, Monosorb® XL, Nyzamac® SR, Relosorb® XL, Tardisc® XL, Trangina® XL, Xismox® XL, Zemon® XL, |
متوفر كـ | Tablets, modified-release (longer-acting) tablets, and modified-release (longer-acting) capsules |
Isosorbide mononitrate helps to prevent الذبحة الصدرية chest pain from developing. Angina pain develops if part of your heart muscle does not get as much blood and oxygen as it needs. It is usually caused by narrowing of your coronary arteries due to a build-up of a fatty substance called atheroma. The narrowing makes it more difficult for blood to flow to your heart muscle.
Isosorbide mononitrate works in two ways. It relaxes blood vessels in your body (causing them to widen) and this reduces the strain on your heart, making it easier for your heart to pump blood around your body. It also relaxes and widens blood vessels in your heart (coronary arteries) which increases the flow of blood to your heart muscle.
Isosorbide mononitrate is also sometimes prescribed alongside other medicines for people with فشل القلب. This is a condition where the heart does not beat as efficiently as it should.
Before taking isosorbide mononitrate
العودة إلى المحتوياتSome medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start taking isosorbide mononitrate it is important that your doctor knows:
إذا كنت حاملاً أو مرضعة.
إذا كان لديك أي مشاكل في طريقة عمل الكبد لديك، أو أي مشاكل في طريقة عمل الكلى لديك.
If you have low blood pressure.
If you have been told by a doctor you have low levels of iron in your blood (anaemia), or low levels of oxygen in your blood (hypoxaemia).
إذا كان لديك غدة درقية غير نشطة.
إذا كنت تعاني من حالة في العين تسمى الجلوكوما.
If you have recently had a head injury or a heart attack.
إذا كنت قد تعرضت في أي وقت مضى لرد فعل تحسسي تجاه دواء.
If you are taking other medicines, including those available to buy without a prescription, as well as herbal or complementary medicines. It is particularly important that you tell your doctor if you are using any medicines to help treat erectile dysfunction.
تابع القراءة أدناه
How to take isosorbide mononitrate
العودة إلى المحتوياتBefore you start the treatment, read the manufacturer's printed information leaflet from inside the pack. It will give you more information about nitrate medicines, and it will also provide you with a full list of side-effects which you could experience from taking isosorbide mononitrate.
Some brands of isosorbide mononitrate tablets should be taken two or three times a day. Longer-acting tablets and capsules are taken once daily in the morning. Your doctor will tell you which is the right dose for you, and this will also be printed on the label of the pack to remind you about what the doctor said to you. You can take your doses either before or after meals.
Swallow the tablet/capsule whole - do not chew or crush it before you swallow. This is because the tablets/capsules are specially made to release the medicine they contain in a controlled way.
If you forget to take a dose, take it as soon as you remember. If you do not remember until your next dose is nearly due, then leave out the forgotten dose and take your next dose when it is due. Do not take two doses together to make up for a missed dose.
تحقيق أقصى استفادة من علاجك
العودة إلى المحتوياتIsosorbide mononitrate tablets and capsules are not suitable to take to treat the pain of an angina attack. Your doctor will prescribe you a short-acting nitrate for you to take if this happens. Glyceryl trinitrate (GTN) is commonly prescribed for this.
Try to keep your regular appointments with your doctor. This is so your doctor can check on your progress
The longer you take isosorbide mononitrate, the more your body can become used to it (called tolerance), and then it can have less of an effect. To avoid this, if you are taking more than one dose a day, your doses may not be prescribed at equal intervals throughout the day. It is important that you follow the instructions your doctor gives to you about when to take your doses.
It is best not to drink alcohol while you are on isosorbide mononitrate. Alcohol will increase the risk of you experiencing side-effects such as feeling dizzy and light-headed.
If you are having an operation or dental treatment, please remember to tell the person carrying out the treatment which medicines you are taking.
If you buy any medicines, please check with a pharmacist that they are suitable for you to take with isosorbide mononitrate.
تابع القراءة أدناه
Can isosorbide mononitrate cause problems?
العودة إلى المحتوياتAlong with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the most common ones associated with isosorbide mononitrate. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome.
Common isosorbide mononitrate side-effects | ماذا يمكنني أن أفعل إذا واجهت هذا؟ |
صداع | Ask your doctor or pharmacist to recommend a suitable painkiller. This side-effect usually disappears after a few days |
الشعور بالدوار أو التعب | لا تقم بالقيادة ولا تستخدم الأدوات أو الآلات أثناء التأثر |
Fast heartbeat; flushing | If either of these becomes troublesome, speak with your doctor |
إذا شعرت بأي أعراض أخرى تعتقد أنها قد تكون بسبب الدواء، يرجى التحدث مع طبيبك أو الصيدلي للحصول على مزيد من النصائح.
How to store isosorbide mononitrate
العودة إلى المحتوياتاحفظ جميع الأدوية بعيدًا عن متناول ورؤية الأطفال.
احفظه في مكان بارد وجاف، بعيدًا عن الحرارة المباشرة والضوء.
معلومات هامة عن جميع الأدوية
العودة إلى المحتوياتمعلومات هامة عن جميع الأدوية
لا تأخذ أبدًا أكثر من الجرعة الموصوفة. إذا كنت تشك في أنك أو شخص آخر قد تناول جرعة زائدة من هذا الدواء، اذهب إلى قسم الحوادث والطوارئ في مستشفى منطقتك. خذ العبوة معك، حتى لو كانت فارغة.
هذا الدواء لك. لا تعطه لأشخاص آخرين حتى لو بدت حالتهم مشابهة لحالتك.
لا تحتفظ بالأدوية منتهية الصلاحية أو غير المرغوب فيها. خذها إلى صيدليتك المحلية التي ستتولى التخلص منها نيابة عنك.
إذا كان لديك أي أسئلة حول هذا الدواء، اسأل الصيدلي الخاص بك.
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الأسئلة الشائعة
What is angina and how does isosorbide mononitrate help?
Angina is chest pain that occurs when your heart muscle doesn't get enough blood and oxygen. This is often due to narrowed coronary arteries caused by a fatty substance called atheroma. Isosorbide mononitrate helps by relaxing and widening blood vessels in your body, which reduces the strain on your heart, and also directly widens the coronary arteries to improve blood flow to the heart muscle.
Can I take isosorbide mononitrate if I have heart failure?
Yes, isosorbide mononitrate is sometimes prescribed alongside other medicines for people with heart failure. Heart failure is a condition where the heart does not pump blood as efficiently as it should.
Can I crush or chew my isosorbide mononitrate tablets or capsules?
No, you should swallow the tablet or capsule whole. Do not chew or crush it. This is because these forms of the medicine are specially designed to release the medication in a controlled way over time.
Can I drink alcohol while taking isosorbide mononitrate?
It is best not to drink alcohol while you are taking isosorbide mononitrate. Alcohol can increase your risk of experiencing side-effects such as feeling dizzy and light-headed.
What should I do if I forget to take a dose of isosorbide mononitrate?
If you forget to take a dose, take it as soon as you remember. However, if your next dose is nearly due, then you should skip the forgotten dose and take your next dose at the usual time. Do not take two doses together to make up for a missed dose.
Will my body get used to isosorbide mononitrate over time?
Yes, your body can become used to isosorbide mononitrate over time, which is called tolerance, and this can make the medicine less effective. To help prevent this, if you are prescribed more than one dose a day, your doctor may instruct you to take your doses at specific intervals to ensure a period without the medicine each day. It is important to follow your doctor's instructions about when to take your doses.
Are there any medicines I should definitely avoid taking with isosorbide mononitrate?
It is particularly important to tell your doctor if you are using any medicines to help treat erectile dysfunction. You should also check with a pharmacist about any other medicines you buy, including herbal or complementary ones, to ensure they are suitable to take with isosorbide mononitrate.
قراءة إضافية ومراجع
- Manufacturer's PIL, Imdur 60 mg tablets; TopRidge Pharma Ltd, The electronic Medicines Compendium. Dated August 2017.
- Manufacturer's PIL, Isosorbide mononitrate 10 mg tablets; Dexcel Pharma Ltd, The electronic Medicines Compendium. Dated December 2017.
- الأدوية كاملة BNF الطبعة 89; الجمعية الطبية البريطانية والجمعية الملكية الصيدلانية لبريطانيا العظمى، لندن.
تابع القراءة أدناه
About the authorView full bio

مايكل ستيوارت، MRPharmS
Medicine Leaflet Review Manager – Contractor, Pharmacist
BPharm (Hons), MRPharmS
Michael is a community pharmacist practicing in the Midlands and South Yorkshire with more than 20 years’ experience advising on medicines and medical conditions. He has a strong background in healthcare training, having produced and delivered training courses for pharmacy teams and staff of residential care settings, including nurses. He has also contributed to pharmacy advisory boards for the management of low acuity conditions in the community.
About the reviewer

سيد داجاني
Sultan Dajani qualified at the London School of Pharmacy in 1994 and became the youngest elected member of the Royal Pharmaceutical Society council since its founding in 1842.
تاريخ المقال
تمت كتابة المعلومات على هذه الصفحة ومراجعتها من قبل أطباء مؤهلين.
Next review due: 16 Oct 2027
20 أكتوبر 2024 | أحدث إصدار

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