نيستجمين لعلاج الوهن العضلي الوبيل

About neostigmine

الوهن العضلي الوبيل is a condition where your muscles become easily tired and weak. There is a fault in the way nerve messages are passed from your nerves to your muscles. As a consequence, your muscles are not stimulated properly, so do not tighten (contract) well. The muscles around the eyes are commonly affected first. Myasthenia gravis is an autoimmune disease. This means that the fault is due to a problem with your immune system. Your immune system (which normally protects your body from infections) mistakenly attacks itself.

عادةً ما يرسل دماغك رسائل عبر الأعصاب إلى العضلات التي يريد أن ينقبضها. ثم تطلق النهايات العصبية مادة كيميائية تسمى الأستيل كولين. يرتبط الأستيل كولين بسرعة بمناطق صغيرة على عضلاتك، تسمى المستقبلات، وهذا يحفز عضلاتك على الانقباض. في معظم الأشخاص الذين يعانون من الوهن العضلي الوبيل، يقوم الجهاز المناعي بحجب أو إتلاف هذه المستقبلات الخاصة بالأستيل كولين. وبالتالي لا يمكن للأستيل كولين الارتباط بالمستقبل، مما يجعل العضلة أقل قدرة على الانقباض.

Neostigmine works by slowing the breakdown of acetylcholine when it is released from nerve endings. This means that there is more acetylcholine available to attach to the muscle receptors and this improves the strength of your muscles.

Some medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start taking neostigmine it is important that your doctor knows:

• إذا كنت حاملاً أو مرضعة.

• If you have الربو.

• If you have any of the following conditions: epilepsy, مرض باركنسون, an overactive thyroid gland or انخفاض ضغط الدم.

• If you have a heart condition, such as a slow heart rate, or if you have recently had a نوبة قلبية.

• If you have a قرحة في المعدة.

• إذا كان لديك أي مشاكل في طريقة عمل الكلى لديك.

• If you feel you may have a blockage in your intestines or if you have any difficulties passing urine.

• إذا كنت تتناول أو تستخدم أي أدوية أخرى. يشمل ذلك أي أدوية تتناولها والتي يمكن شراؤها بدون وصفة طبية، بالإضافة إلى الأدوية العشبية والمكملات الغذائية.

• إذا كنت قد تعرضت في أي وقت مضى لرد فعل تحسسي تجاه دواء.

• Before you start the treatment, read the manufacturer's printed information leaflet from inside the pack. It will give you more information about neostigmine and will provide you with a full list of the side-effects which you may experience from taking it.

• Take neostigmine tablets exactly as your doctor tells you to. Your dose will be printed on the label of the pack to remind you about what the doctor said to you. For adults, it is usual to take one or two tablets several times a day, as the effect of the tablets lasts for about four hours. Take the tablets at suitable intervals so that your muscles are strongest when you need to be the most active (for example, early in the morning and before meals). When neostigmine is prescribed for a child, the dose is calculated according to the age of the child.

• ابتلع القرص (الأقراص) مع شربة ماء.

• If you forget to take a dose at your usual time, take it when you remember. However, if it is nearly time to take your next dose when you remember then leave out the forgotten dose and take your next dose when it is due. Do not take two doses together to make up for a missed dose.

• حاول الحفاظ على مواعيدك المنتظمة مع طبيبك. هذا لكي يتمكن طبيبك من متابعة تقدمك.

• It is likely that you will be prescribed other medicines to take alongside neostigmine. You may be prescribed an immunosuppressant or corticosteroid medicine to help control your muscle symptoms. You may also be prescribed tablets to reduce some unwanted effects from taking neostigmine. This is because neostigmine can produce side-effects such as tummy (abdominal) cramp and diarrhoea. If you are unsure when or how to take all these medicines, ask your doctor or pharmacist to explain it to you again.

• If you are having an operation or dental treatment, tell the person carrying out the treatment that you are taking neostigmine. This is important because neostigmine interferes with some medicines used during surgery.

• إذا اشتريت أي أدوية، تحقق دائمًا مع الصيدلي من أنها مناسبة لك لتتناولها مع الأدوية الأخرى التي تتناولها.

Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the most common ones associated with neostigmine. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome.

إذا شعرت بأي أعراض أخرى تعتقد أنها قد تكون بسبب الأقراص، تحدث مع طبيبك أو الصيدلي للحصول على مزيد من النصائح.

• احفظ جميع الأدوية بعيدًا عن متناول ورؤية الأطفال.

• احفظه في مكان بارد وجاف، بعيدًا عن الحرارة المباشرة والضوء.