حمض أليندرونيك لعلاج هشاشة العظام

About alendronic acid

هشاشة العظام is a bone disease which causes your bones to become brittle and fragile, making them prone to breaks and fractures. During our lifetime, old bone tissue is constantly being broken down and replaced by new bone. After the age of about 30-35 years, our bone begins to lose density because old bone is lost faster than new bone can replace it. Women in particular have an increased risk of developing osteoporosis, as they lose bone material rapidly after the menopause.

Alendronic acid belongs to a group of medicines known as bisphosphonates. These medicines slow down the rate at which old bone is lost. As your body continues to make new bone, this leads to an overall increase in bone density. This reduces your risk of broken bones and fractures. You may be prescribed alendronic acid to take once a day (10 mg strength tablets), or more commonly, once a week (70 mg strength tablets/medicine).

In the brands of tablets called Fosavance® and Bentexo®, alendronic acid is combined with a vitamin called colecalciferol (also known as vitamin D3). Colecalciferol helps your bones absorb calcium. Because our bodies naturally make colecalciferol from exposure to sunlight and also absorb small amounts from foods such as oily fish, many people do not need supplements of this vitamin. However, as we get older, the amount of colecalciferol we absorb naturally may reduce. This brand of tablet is suitable for people requiring supplements of colecalciferol alongside alendronic acid.

Some medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start taking alendronic acid it is important that your doctor knows:

• إذا كنت حاملاً أو مرضعة.

• إذا كنت قد واجهت أي صعوبات في البلع.

• If you have had a stomach ulcer, stomach bleeding or any surgery on your upper digestive system within the previous year.

• If you are due to have any dental treatment in the near future, or if you have ليست recently had a dental check-up.

• إذا كان لديك أي مشاكل في طريقة عمل الكلى لديك.

• إذا كنت غير قادر على الجلوس بشكل مستقيم لمدة 30 دقيقة على الأقل.

• إذا قيل لك أن لديك مستويات منخفضة من الكالسيوم في دمك.

• إذا كنت تتناول أي أدوية أخرى. يشمل ذلك أي أدوية تتناولها والتي يمكن شراؤها بدون وصفة طبية، بالإضافة إلى الأدوية العشبية والمكملات الغذائية.

• إذا كنت قد تعرضت في أي وقت مضى لرد فعل تحسسي تجاه دواء.
  

• Before you start the treatment, read the manufacturer's printed information leaflet from inside the pack. It will give you more information about alendronic acid and will provide you with a full list of the side-effects which you may experience from taking it.

• If you are taking alendronic acid 10 mg tablets, take one tablet daily. If on any day you forget to take a dose, just take your tablet on the next day as usual. Do not take a double dose to make up for a missed dose.

• If you are taking tablets containing alendronic acid 70 mg (brands Fosamax® Once weekly and Fosavance®), take one tablet once a week. You must take your dose on the same day of each week, so choose a day that best suits your routine. If you forget to take a dose on your usual day, take it on the following morning and then continue taking it on your chosen day when your next dose is due.

• If you are taking alendronic acid 70 mg in 100 ml oral liquid medicine, take 100 ml (one unit) once a week. Take it on the same day of each week. If you forget to take a dose on your usual day, take it on the following morning and then continue taking it on your chosen day when your next dose is due.

Taking alendronic acid

It is important that you take alendronic acid in the correct way, as otherwise it can cause irritation and damage as it is swallowed:

• Take the tablet/medicine first thing after getting up in the morning. Take it before you eat any food or have anything to drink other than water.

• You must drink a large glassful of plain water (not mineral water) as you take your dose. If you are taking tablets, swallow the tablet whole - you must ليست chew, break, or crush alendronic acid tablets.

• It is important that you take your dose while you are standing or sitting in an upright position.

• Continue to sit or stand upright for 30 minutes after taking your dose - you must ليست lie down during this time.

• Do not have anything to eat or drink (other than plain water), or take any other medicines during the 30 minutes after taking a dose.

• Try to keep your regular appointments with your doctor. This is so your doctor can check on your progress. It is likely you will need to have regular blood tests during this treatment.

• If you are taking other medicines, wait at least 30 minutes after taking alendronic acid before taking your other medicines. If you buy any medicines 'over the counter', check with a pharmacist that they are suitable for you to take. This is because mineral supplements, iron preparations, and some indigestion remedies reduce the amount of alendronic acid which your body absorbs. This can make your treatment less effective.

• Good dental hygiene is particularly important while you are taking alendronic acid - brush your teeth regularly and remember to have routine dental check-ups. Tell your dentist that you are taking alendronic acid, as some dental treatments may not be recommended for you.

• Eating a well-balanced diet and taking regular exercise can help your bones stay strong. Remember to follow any exercise or dietary advice that your doctor gives to you.

• Chemicals from tobacco can get into your bloodstream and can affect your bones, making bone loss worse. If you are a smoker, you should try to quit if possible. Ask your doctor or pharmacist for advice on how to stop smoking.

Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the most common ones associated with alendronic acid. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome.

إذا شعرت بأي أعراض أخرى تعتقد أنها قد تكون بسبب الدواء، تحدث مع طبيبك أو الصيدلي للحصول على مزيد من النصائح.

• احفظ جميع الأدوية بعيدًا عن متناول ورؤية الأطفال.

• احفظه في مكان بارد وجاف، بعيدًا عن الحرارة المباشرة والضوء.