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الفنتانيل لتخفيف الألم

Durogesic, Matrifen, Abstral

هذا الدواء هو مسكن أفيوني. هناك خطر جدي للإدمان عند تناول هذا الدواء، خاصة إذا تم استخدامه لفترة طويلة. The Medicines and Healthcare products Regulatory Agency (MHRA) has issued إرشادات جديدة للأشخاص الذين تم وصف مسكن أفيوني لهم. إذا كان لديك أي أسئلة أو مخاوف بشأن تناول الأفيونات بأمان، يرجى التحدث مع طبيبك أو الصيدلي.

Fentanyl is prescribed to treat severe pain.

The most common side effects of fentanyl are feeling sick (nausea), constipation, and feeling sleepy.

If you start to feel extremely sleepy or your breathing becomes slow or shallow, you should contact your doctor straightaway.

Fentanyl is likely to affect your reactions and ability to drive. It may be an offence to drive while affected. Do not drive until you know how you react.

نظرة سريعة

  • Fentanyl is a strong opioid painkiller used for severe or chronic pain.

  • It comes as patches, lozenges, various tablets, nasal sprays, and injections.

  • Common side effects include constipation, feeling sick, dizziness, and sleepiness.

  • Do not drink alcohol or drive if you feel drowsy or dizzy.

  • Heat sources on patches or a high temperature can increase fentanyl absorption.

  • Stopping fentanyl suddenly can cause withdrawal symptoms.

  • Seek immediate medical help if breathing becomes slow or shallow, or for overdose signs.

About fentanyl

نوع الدواء

A strong opioid painkiller (analgesic)

يستخدم لـ

تخفيف الألم

يُعرف أيضًا باسم

Brands of fentanyl patches: Durogesic DTrans®; Fencino®; Matrifen®; Mezolar®; Opiodur®; Victanyl®; Yemex®
Brand of fentanyl lozenges
: Actiq®; Cynril®
Brands of fentanyl sublingual tablets
: Abstral®; Iremia®
Brand of fentanyl buccal tablets
: Effentora®
Brands of fentanyl nasal sprays
: Instanyl®; PecFent®

متوفر كـ

Patch, lozenge, tablets to dissolve in the mouth (buccal), tablets to dissolve under the tongue (sublingual), nasal spray, injection

What is fentanyl used for?

Fentanyl is a مسكن أفيوني قوي that is used to treat severe or chronic pain.

If you have long-term (chronic) pain, you may be prescribed a fentanyl skin patch. This is called transdermal fentanyl. The patch releases fentanyl slowly over time to give continuous pain relief.

Sometimes, pain may still break through. This is called breakthrough pain. In these cases, fentanyl may be given in other forms, such as lozenges, tablets, films, or nasal sprays, which are taken when needed for fast pain relief.

Fentanyl can also be given as an injection during surgery to help control pain.

How does fentanyl work?

It works by binding to certain tiny areas, called opioid receptors, in your brain and spinal cord (central nervous system). This leads to a decrease in the way you feel pain and your reaction to pain.

Side effects of الفنتانيل

Common side effects of fentanyl include:

  • الإمساك.

  • الشعور بالغثيان.

  • التقيؤ.

  • الشعور بالدوار.

  • الشعور بالنعاس أو التعب.

  • Breathing problems.

  • الصداع.

  • ألم في المعدة (البطن).

ستجد قائمة كاملة في النشرة المعلوماتية الخاصة بالشركة المصنعة المرفقة مع دوائك.

غالبًا ما تتحسن الآثار غير المرغوب فيها مع تكيف جسمك مع الدواء الجديد، ولكن تحدث مع طبيبك أو الصيدلي إذا استمرت أي آثار جانبية أو أصبحت مزعجة.

How to manage fentanyl side effects

Common fentanyl side effects

ماذا يمكنني أن أفعل إذا واجهت هذا؟

الإمساك

Try to eat a well-balanced diet and drink plenty of water each day. If this continues your doctor may prescribe a laxative for you

Feeling sick (nausea) or being sick

This usually passes after a few days, but let your doctor know if it continues. Your doctor may prescribe a medicine to ease the sickness

الشعور بالنعاس أو التعب أو الدوار

لا تقود السيارة ولا تستخدم الأدوات أو الآلات. لا تشرب الكحول

Breathing problems

If your breathing becomes slow or shallow, you should contact your doctor straightaway

Dry or sore mouth, diarrhoea, indigestion, tummy pain (may be caused by spasm of the bile ducts), mood changes, headache, sweating, itchy skin rash

تحدث مع طبيبك إذا كان هناك مشكلة

Local irritation where a patch or tablet has been

As much as possible, vary the sites where the patches or tablets are placed. If this becomes a problem, let your doctor know

مهم: people taking opioid painkillers, and their family and friends, should be aware of the risk of accidental overdose and know when to seek medical help. The risk is higher if you also take other medicines that make you feel drowsy. Signs you have taken too much medicine include:

  • الشعور بالنعاس الشديد أو الدوار.

  • الشعور بالغثيان (الغثيان) أو التقيؤ (القيء).

  • صعوبات في التنفس.

  • فقدان الوعي.

If you have taken more medication than you should or someone else accidentally swallows your medication, call for an ambulance and tell them the name of your medicine.

If you experience other symptoms which you think may be due to fentanyl, speak with your doctor or pharmacist for further advice.

Who should not take fentanyl?

Some medicines are not suitable for people with certain conditions. Before taking fentanyl it is important that your doctor knows:

  • إذا كنت حاملاً أو مرضعة.

  • إذا كان لديك مشكلة في طريقة عمل الكبد لديك، أو مشكلة في طريقة عمل الكلى لديك.

  • If you have a sore mouth or السكري. This is because some brands of fentanyl may not be suitable for you to take.

  • إذا كنت تعاني من مشاكل في البروستاتا أو أي صعوبات في التبول.

  • If you have any breathing problems, such as الربو أو مرض الانسداد الرئوي المزمن (COPD).

  • If you have been told you have انخفاض ضغط الدم.

  • إذا كان لديك أي مشاكل في الغدة الدرقية أو الغدد الكظرية.

  • If you have الصرع.

  • إذا كان لديك مشكلة في القناة الصفراوية.

  • إذا كنت تعاني من الإمساك لأكثر من أسبوع أو لديك مشكلة التهاب الأمعاء.

  • If you have a condition causing muscle weakness, called الوهن العضلي الوبيل.

  • If you have recently had a severe head injury, or have a brain tumour.

  • إذا كنت قد اعتمدت في أي وقت مضى على المخدرات أو الكحول.

  • إذا كنت قد تعرضت في أي وقت مضى لرد فعل تحسسي تجاه دواء.

  • إذا كنت تتناول أي أدوية أخرى. يشمل ذلك أي أدوية تتناولها والتي يمكن شراؤها بدون وصفة طبية، بالإضافة إلى الأدوية العشبية والمكملات الغذائية.

How to use fentanyl

  • Use fentanyl exactly as prescribed by your doctor.

  • Fentanyl comes in different forms, so your doctor or pharmacist will explain how to use yours.

  • When you first start fentanyl, your dose is usually increased gradually to find the right level for your pain and reduce side effects.

  • Once the correct dose is found, keep using the same dose unless your doctor tells you to change it.

  • Check the label on the pack for your dose and follow the instructions carefully.

  • If you are unsure about the dose or how to use it, ask your pharmacist for advice.

If you are using fentanyl patches

  • Open the pouch carefully and check the patch is not damaged. Keep the pouch to safely dispose of the patch later.

  • Apply to clean, dry, healthy skin on your upper arm or upper body. Press firmly for about 30 seconds, especially around the edges. Avoid touching the sticky side. Wash your hands after applying.

  • It may take up to 24 hours for the patch to reach full effect, so you may need other pain relief during this time.

  • Leave the patch on for 72 hours (3 days). After this, remove it and apply a new patch to a different area. Change it at the same time of day each time.

  • Dispose of used patches safely: fold it sticky side inwards, put it in the pouch, and follow your doctor’s instructions. Keep out of reach of children.

  • Avoid heat sources on the patch, such as heating pads, hot water bottles, electric blankets, heated water beds, long hot baths, saunas, or sunbathing. Heat can release too much fentanyl and increase the risk of overdose.

  • Tell your doctor if you develop a high temperature, as this can also increase fentanyl absorption.

  • Always check your brand when getting a new prescription. Different brands may release fentanyl differently; stick to the same brand unless your doctor advises otherwise.

  • Watch for signs of too much fentanyl: shallow or weak breathing, extreme sleepiness, confusion, slurred speech, or severe dizziness. If these happen, remove the patch and contact your doctor immediately.

If you are using fentanyl lozenges (Actiq®)

  • Use the applicator to move the lozenge around your mouth while you suck it. Let it touch your tongue and inside of your cheeks.

  • Do not chew or swallow the lozenge. Fentanyl is absorbed through the lining of your mouth.

  • If your mouth is dry, moisten it with water before using the lozenge.

  • Suck one lozenge over about 15 minutes.

  • If your pain has not eased within 15 minutes after finishing the lozenge, you may suck another one.

  • Do not use more than two lozenges for one episode of pain, or more than four in 24 hours.

  • If your pain is not controlled, tell your doctor.

If you are using fentanyl sublingual tablets (Abstral®)

  • Place the tablet under your tongue and let it dissolve completely.

  • Do not chew, suck, or swallow the tablet.

  • You can moisten your mouth with water before use, but do not eat or drink while it is dissolving.

  • If your pain hasn’t eased in 15-30 minutes, you may use one more tablet.

  • Do not use more than two tablets for one episode of pain.

  • Wait at least 2 hours before treating a new episode of breakthrough pain.

  • If you have more than four episodes of breakthrough pain in 24 hours, tell your doctor.

  • If pain is still not controlled, contact your doctor.

If you are using fentanyl buccal tablets (Effentora®)

  • Place the tablet between your gum and cheek and let it dissolve completely.

  • Do not chew, suck, or swallow the tablet.

  • You can moisten your mouth with water before use, but do not eat or drink while it is dissolving.

  • If after 30 minutes small pieces remain, you can swallow them with water.

  • If pain hasn’t eased in 30 minutes, you may use another tablet on the other side of your mouth or under your tongue.

  • Do not use more than two tablets for one episode of pain.

  • Wait at least 4 hours before treating another episode of breakthrough pain.

  • If pain is still not controlled, contact your doctor.

If you are using fentanyl nasal spray (PecFent®)

  • Sit or stand while using the spray.

  • Bend your head slightly forward and hold the spray upright.

  • Close one nostril with a finger and insert the tip into the other nostril.

  • Spray once while breathing in through your nose.

  • If pain hasn’t eased in 10 minutes, use a second spray in the other nostril.

  • Do not use more than two sprays for one episode of pain.

  • Wait at least 4 hours before treating another episode.

  • If pain is not controlled, or if you have more than four episodes of breakthrough pain in 24 hours, contact your doctor.

تحقيق أقصى استفادة من علاجك

  • Do not drink alcohol while taking fentanyl. Alcohol can increase side effects like dizziness and sleepiness.

  • Fentanyl is only given for as long as needed. Long-term use can cause tolerance (the medicine works less) and dependence, which may lead to withdrawal symptoms if it is stopped suddenly. Your doctor will reduce your dose gradually when it’s no longer needed.

  • Fentanyl can slow your reactions. Do not drive if you feel drowsy or dizzy. Even if you feel safe, carry proof that fentanyl is prescribed (such as prescription slip or patient leaflet).

  • Tell your doctor, dentist, or other healthcare professional that you are taking fentanyl before having any procedures or dental treatment.

  • Before taking other medicines check with a pharmacist that they are safe to take with fentanyl.

  • Fentanyl is a controlled drug, so carry a letter from your doctor when travelling. For trips longer than three months, you must apply to the Home Office for a licence to take fentanyl with you.

How to store fentanyl

  • Keep all medicines out of the reach and sight of children. This includes used patches and part-finished lozenges.

  • احفظه في مكان بارد وجاف، بعيدًا عن الحرارة المباشرة والضوء.

معلومات هامة عن جميع الأدوية

معلومات هامة عن جميع الأدوية

لا تأخذ أبدًا أكثر من الجرعة الموصوفة. إذا كنت تشك في أنك أو شخص آخر قد تناول جرعة زائدة من هذا الدواء، اذهب إلى قسم الحوادث والطوارئ في مستشفى منطقتك. خذ العبوة معك، حتى لو كانت فارغة.

هذا الدواء لك. لا تعطه لأشخاص آخرين حتى لو بدت حالتهم مشابهة لحالتك.

لا تحتفظ بالأدوية منتهية الصلاحية أو غير المرغوب فيها. خذها إلى صيدليتك المحلية التي ستتولى التخلص منها نيابة عنك.

إذا كان لديك أي أسئلة حول هذا الدواء، اسأل الصيدلي الخاص بك.

MHRA - الإبلاغ عن التفاعلات الضارة

أبلغ عن الآثار الجانبية المشتبه بها للأدوية واللقاحات والسجائر الإلكترونية وحوادث الأجهزة الطبية والمنتجات المعيبة أو المزيفة (المزورة) إلى وكالة تنظيم الأدوية ومنتجات الرعاية الصحية لضمان الاستخدام الآمن والفعال.

الأسئلة الشائعة

How long does it take for fentanyl to work?

Fentanyl usually starts to work within minutes, although the exact timing depends on how it is taken. Injected fentanyl works in 1-5 minutes, lozenges or nasal sprays in 5-15 minutes, and fentanyl patches begin providing pain relief after 12-24 hours.

How long does fentanyl stay in your system?

Fentanyl can stay in your system for 1 to 3 days, depending on dose and method of use. It is typically detectable for up to 24 hours in blood, 1-3 days in urine, 48 hours in saliva, and up to 90 days in hair. Fentanyl patches may cause longer-lasting effects.

Is fentanyl addictive?

Yes, fentanyl is highly addictive, even when prescribed. It is a strong opioid painkiller that can cause physical dependence, tolerance, and opioid addiction, particularly with long-term or non-medical use.

Is fentanyl stronger than morphine?

Yes, fentanyl is much stronger than morphine. It is around 50 to 100 times more potent, meaning much smaller doses are needed to achieve the same level of pain relief.

What happens when you stop taking fentanyl?

Stopping fentanyl suddenly can cause withdrawal symptoms. Common symptoms include muscle aches, anxiety, sweating, feeling sick, diarrhoea, and sleep problems. Doctors usually recommend gradually reducing the dose to minimise withdrawal.

مدقق الأعراض

غير متأكد من خلط الأدوية؟

تحقق من التفاعلات المحتملة بين الأدوية والمكملات الغذائية والأطعمة قبل تناولها معًا.

الأسئلة الشائعة

What should I do if I miss a dose of fentanyl?

The article states to use fentanyl exactly as prescribed. Missing a dose is not explicitly covered, but generally with strong painkillers, it's advised to take the next dose as soon as you remember unless it's nearly time for your next scheduled dose. Never take a double dose to make up for a forgotten one. For specific guidance, you should refer to the manufacturer's information leaflet or contact your doctor or pharmacist.

Can children or pets be harmed by fentanyl?

Yes, fentanyl can be very harmful to children and pets. The article explicitly states to keep all medicines, including used patches and part-finished lozenges, out of the reach and sight of children. This implies the potential for harm if ingested or if a child or pet comes into contact with it.

Is it safe to drive while taking fentanyl?

Fentanyl can slow your reactions due to side effects like sleepiness and dizziness. Therefore, you should not drive if you feel drowsy or dizzy. The article also advises carrying proof that fentanyl is prescribed if you do need to travel, even if you feel safe to drive.

What is the best way to dispose of fentanyl patches?

When disposing of used fentanyl patches, fold them sticky side inwards, put them in the pouch they originally came in, and follow your doctor’s specific instructions for final disposal. This helps ensure they are safely handled and kept out of reach of children.

Can I take other medications with fentanyl?

Before taking any other medicines, including those available without a prescription, herbal remedies, or complementary medicines, you should always check with a pharmacist to ensure they are safe to take with fentanyl. This is important to avoid potential interactions or increased side effects.

قراءة إضافية ومراجع

عن المؤلفعرض السيرة الذاتية الكاملة

صورة المؤلف

مايكل ستيوارت، MRPharmS

مدير مراجعة النشرات الطبية – متعاقد، صيدلي

بكالوريوس الصيدلة (مع مرتبة الشرف)، عضو الجمعية الملكية للصيادلة

مايكل هو صيدلي مجتمعي يمارس عمله في منطقة ميدلاندز وجنوب يوركشاير ولديه أكثر من 20 عامًا من الخبرة في تقديم المشورة بشأن الأدوية والحالات الطبية. لديه خلفية قوية في تدريب الرعاية الصحية، حيث قام بإنتاج وتقديم دورات تدريبية لفرق الصيدلة وموظفي دور الرعاية السكنية، بما في ذلك الممرضات. كما ساهم في مجالس استشارية للصيدلة لإدارة الحالات ذات الحدة المنخفضة في المجتمع.

حول المراجععرض السيرة الذاتية الكاملة

صورة المؤلف

الدكتور كولين تايدي، MRCGP

طبيب عام، مؤلف طبي

MBBS, MRCGP, MRCP (Paediatrics), DCH

الدكتور كولين تايدي هو طبيب في هيئة الخدمات الصحية الوطنية، ويعمل في أوكسفوردشاير.

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