About rufinamide

Having epilepsy means that you have had more than one unexplained fit, or seizure. A seizure is a short episode of symptoms caused by a burst of abnormal electrical activity in your brain. Because different parts of the brain control different functions, your symptoms will depend on which part of your brain is affected. Symptoms that may occur during a seizure can affect your muscles, sensations, behaviour, emotions, and consciousness, or a combination of these.

Rufinamide is prescribed for a type of epilepsy known as Lennox-Gastaut syndrome. This is a severe form of epilepsy which usually begins in early childhood. Rufinamide works by stabilising the electrical activity of the brain, which reduces the number of seizures which occur. It is given alongside other antiepileptic medicines.

Some medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you (or your child if you are their carer) start taking rufinamide, it is important that your doctor knows:

• إذا كان لديك أي مشاكل في كيفية عمل الكبد لديك.

• إذا كنت تتناول أي أدوية أخرى. يشمل ذلك أي أدوية تتناولها والتي يمكن شراؤها بدون وصفة طبية، بالإضافة إلى الأدوية العشبية والمكملات الغذائية.

• إذا كنت قد تعرضت في أي وقت مضى لرد فعل تحسسي تجاه دواء.

• إذا كنتِ حاملاً، تحاولين الإنجاب، أو تقومين بالرضاعة الطبيعية.

• Before you start the treatment, read the manufacturer's printed information leaflet from inside the pack. It will give you more information about rufinamide and will provide you with a full list of the side-effects which you may experience from taking it.

• Take rufinamide exactly as your doctor tells you to. Your dose will be printed on the label of the pack to remind you about what the doctor said. There are several different strengths of rufinamide tablets. It is usual to start treatment on a low dose, and then for the dose to be increased gradually to a regular maintenance dose. You will be prescribed two doses a day: one dose to take in the morning and the other in the evening.

• It is important you try to take your doses at the same times of day - having a routine will help you to remember to take the doses regularly.

• You should take rufinamide with, or just after, a meal. Swallow the tablet with a drink of water. If you have difficulty swallowing tablets, you can crush the tablet and mix it into a small glassful of water.

• If you have been supplied with the oral liquid medicine (Inovelon® suspension), shake the bottle well before you measure out a dose. Instructions for using the dose syringe supplied with the suspension are below.

• If you forget to take a dose, take it as soon as you remember. If when you remember, it is nearly time for your next dose then take your next dose when it is due but leave out the missed dose. Do not take two doses together to make up for a forgotten dose.

Instructions for using the Inovelon® suspension dosing syringe

1. Shake the bottle well.

2. Remove the bottle cap, and push the adaptor into the top of the open bottle.

3. أدخل المحقنة في المحول.

4. اقلب الزجاجة (مع المحقنة المتصلة بها) رأسًا على عقب.

5. Gently pull out the plunger of the syringe so that the suspension fills the syringe to the mark which corresponds to your dose.

6. أعد الزجاجة إلى وضعها الصحيح مرة أخرى، وقم بإزالة المحقنة من الزجاجة.

7. Leave the adaptor in place, and replace the cap on the bottle.

8. Put the tip of the syringe into your (or your child's) mouth, and gently push the plunger so that the liquid is released into your (or your child's) mouth.

• عند البدء في علاج جديد للصرع، قد يحدث تغيير في عدد أو نوع النوبات التي تعاني منها. سيقوم طبيبك بإرشادك حول هذا الأمر.

• Try to keep your regular appointments with your doctor. This is so your doctor can check on your (or your child's) progress.

• Different formulations of some antiepileptic medicines can act in a slightly different way in your body. Because of this, your doctor may recommend that you continue to take the same form of rufinamide (that is, tablets or liquid medicine) from the same manufacturer each time you obtain a new supply. If so, each time you collect a prescription, check to make sure your supply looks the same and that the name is the same. If you are unsure, or if you have any questions about your prescription, please ask your pharmacist to advise you.

• أثناء تلقيك العلاج من الصرع، هناك خطر صغير بأن تتطور لديك تغييرات في المزاج، أفكار مزعجة ومشاعر حول الانتحار. إذا حدث ذلك، يجب عليك إبلاغ طبيبك على الفور.

• يجب على الأشخاص المصابين بالصرع التوقف عن القيادة في البداية. سيقوم طبيبك بإرشادك حول متى يمكن أن يكون من الممكن لك البدء في القيادة مرة أخرى. عادةً ما يكون ذلك بعد مرور عام خالٍ من النوبات.

• إذا كنت تشرب الكحول، استشر طبيبك للحصول على النصيحة. قد ينصحك طبيبك بعدم شرب الكحول أثناء تناولك لهذا الدواء.

• If you buy any medicines, check with a pharmacist that they are suitable for you to take with your antiepileptic medication.

• Many antiepileptic medicines can harm an unborn child. If you are a woman, make sure you have discussed with your doctor which types of contraception are suitable for you and your partner. If you want to have a family, discuss this with your doctor so that you can be given advice from a specialist قبل you become pregnant.

• You need to take rufinamide regularly every day. Do not stop taking it unless your doctor tells you to stop. Stopping treatment suddenly can cause problems and your doctor will want you to reduce your dose gradually if this becomes necessary.

Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the most common ones associated with rufinamide. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome.

إذا شعرت بأي أعراض أخرى تعتقد أنها قد تكون بسبب الدواء، تحدث مع طبيبك أو الصيدلي للحصول على مزيد من النصائح.

• احفظ جميع الأدوية بعيدًا عن متناول ورؤية الأطفال.

• احفظه في مكان بارد وجاف، بعيدًا عن الحرارة المباشرة والضوء.