Tacrolimus ointment
Protopic
مراجعة من قبل Sid Dajaniآخر تحديث بواسطة Michael Stewart, MRPharmSLast updated 14 أغسطس 2023
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Tacrolimus ointment is for external use only and should be applied thinly to affected area(s) of skin.
Do not apply the ointment to any areas of skin which could be infected.
Expect to see an improvement within one week of using the ointment and then continue to use it for a few more weeks until the eczema has cleared.
Do not drink alcohol - it can make your skin (particularly on your face) become flushed or red, and feel hot.
At a glance
Tacrolimus ointment is used for moderate to severe eczema in adults and children over 2 years old.
It is applied to the skin to reduce inflammation, redness, and itching.
Use a thin layer twice daily, avoiding eyes, mouth, and nose.
Do not cover treated skin with dressings or bandages.
Avoid strong sunlight and sunbeds while using this ointment.
Tell your doctor if your skin does not improve after two weeks.
Common side effects include burning and itching which usually improve within a week.
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تابع القراءة أدناه
About tacrolimus ointment
نوع الدواء | A topical immunomodulator |
يستخدم لـ | Moderate-to-severe eczema in adults or in children over 2 years of age |
يُعرف أيضًا باسم | Protopic® |
متوفر كـ | مرهم |
Tacrolimus ointment helps reduce inflammatory skin reactions. It is prescribed for people with moderate-to-severe الأكزيما, usually as an alternative to other treatments such as steroid creams or ointments. It is applied topically (on to the skin) to reduce symptoms such as inflammation, redness and itching. Tacrolimus ointment is available in two strengths: 0.03% and 0.1%. Only the lower, 0.03% strength, is suitable for use by children. It will be prescribed initially by a skin specialist doctor.
Tacrolimus is also available as a medicine which is taken by mouth, but this is prescribed for a completely different medical condition. There is a separate information leaflet available about this, called Tacrolimus to prevent organ rejection.
Before using tacrolimus ointment
العودة إلى المحتوياتSome medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start using tacrolimus ointment it is important that your doctor knows:
إذا كنتِ حاملاً، تحاولين الإنجاب أو تقومين بالرضاعة الطبيعية.
If you have any other skin conditions.
If you have swollen lymph glands or a weakened immune system.
إذا كنت تواجه مشاكل في طريقة عمل الكبد لديك.
If you have ever had an allergic reaction to a medicine, especially if it was to a macrolide antibiotic (such as erythromycin, clarithromycin, azithromycin or telithromycin).
إذا كنت تتناول أو تستخدم أي أدوية أخرى. يشمل ذلك أي أدوية تتناولها والتي يمكن شراؤها بدون وصفة طبية، بالإضافة إلى الأدوية العشبية والمكملات الغذائية.
تابع القراءة أدناه
How to use tacrolimus ointment?
العودة إلى المحتوياتBefore you start the treatment, read the manufacturer's printed information leaflet from inside the pack. It will give you more information about the ointment and will provide you with a full list of the side-effects which you may experience from using it.
Apply a thin layer of ointment to the commonly affected areas of your skin twice daily (it is usually recommended that you apply it morning and evening). It can be applied to most areas of skin on your body, but do not apply it to areas such as your lips, the inside of your nose, or near to your eyes. Do not apply it to any area of skin that could be infected. Remember to wash your hands well with soap and water after using the ointment unless you are treating your hands.
If you forget to apply the ointment, apply it as soon as you remember and then continue as before.
تحقيق أقصى استفادة من علاجك
العودة إلى المحتوياتحاول الحفاظ على مواعيدك المنتظمة مع طبيبك. هذا لكي يتمكن طبيبك من متابعة تقدمك.
Continue to use the ointment until your eczema has cleared. You should expect to see some improvement to your skin within one week of using the ointment, and it should be free from flares within a few more weeks. During this time, your doctor may ask you to reduce how often you apply the ointment or may reduce the strength of the ointment you are using.
Tacrolimus ointment is intended to be used for a short period of time (up to six weeks). It should not be used every day over a long period of time. Some people who frequently have flares may be prescribed the ointment to use on two days of each week to prevent further flares from developing. When it is used like this to prevent flares, there should be at least 2-3 days between applications.
You may continue to use moisturising creams and lotions whilst you are being treated with tacrolimus, but you should wait for at least two hours after you have applied tacrolimus ointment before applying them.
It is important that you don't cover any area of skin treated with tacrolimus with any dressings or bandages. This is because more of the medicine may be absorbed by your skin than is intended.
Do not drink alcohol because it can cause your skin and face to become flushed or red, and feel hot.
Your doctor will discuss with you the possibility of a slightly increased risk of cancer (particularly skin cancer) associated with medicines like tacrolimus. To help reduce this risk, do not use sunbeds, and avoid strong sunlight. On bright days, even if it is cloudy, use a sun cream with a high sun protection factor (an SPF of at least 15).
If there is no improvement in your skin after using tacrolimus ointment for two weeks, you should see your doctor again for further advice.
تابع القراءة أدناه
Can tacrolimus ointment cause problems?
العودة إلى المحتوياتAlong with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the most common ones associated with tacrolimus ointment. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome.
Very common tacrolimus ointment side-effects (these affect more than 1 in 10 people) | ماذا يمكنني أن أفعل إذا واجهت هذا؟ |
A burning sensation, itching | These symptoms generally disappear within one week |
Common مرهم تاكروليموس side-effects (these affect fewer than 1 in 10 people) | ماذا يمكنني أن أفعل إذا واجهت هذا؟ |
Redness, a feeling of warmth, pain, increased skin sensitivity to heat and cold, tingling, rash, local skin infections, cold sores | If any continue or become troublesome, speak with your doctor |
If you experience any other symptoms which you think may be due to the ointment, speak with your doctor or pharmacist for further advice.
How to store tacrolimus ointment?
العودة إلى المحتوياتاحفظ جميع الأدوية بعيدًا عن متناول ورؤية الأطفال.
احفظه في مكان بارد وجاف، بعيدًا عن الحرارة المباشرة والضوء.
معلومات هامة عن جميع الأدوية
العودة إلى المحتوياتمعلومات هامة عن جميع الأدوية
إذا كنت ستخضع لعملية جراحية أو علاج أسنان، أخبر الشخص الذي يقوم بالعلاج عن الأدوية التي تستخدمها.
هذا الدواء لك. لا تعطه لأشخاص آخرين حتى لو بدت حالتهم مشابهة لحالتك.
The ointment is for use on the skin only. If you suspect that someone has swallowed some of it, go to the accident and emergency department of your local hospital. Take the container with you, even if it is empty.
لا تحتفظ بالأدوية منتهية الصلاحية أو غير المرغوب فيها. خذها إلى صيدليتك المحلية التي ستتولى التخلص منها نيابة عنك.
إذا كان لديك أي أسئلة حول هذا الدواء، اسأل الصيدلي الخاص بك.
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تحقق من التفاعلات المحتملة بين الأدوية والمكملات الغذائية والأطعمة قبل تناولها معًا.
الأسئلة الشائعة
Can I use tacrolimus ointment on my child's eczema?
Yes, tacrolimus ointment can be used for children over 2 years of age with moderate-to-severe eczema. However, only the lower 0.03% strength is suitable for children.
How long should I expect to use tacrolimus ointment for my eczema?
Tacrolimus ointment is typically intended for short-term use, up to six weeks, to clear eczema flares. You should expect to see some improvement within one week and for skin to be flare-free within a few more weeks. Your doctor may adjust the application frequency or strength during this time. For some people who experience frequent flares, it might be prescribed for use on two days each week to prevent new flares, with at least 2-3 days between applications.
What if I don't see an improvement in my eczema after using the ointment?
If your skin does not show any improvement after using tacrolimus ointment for two weeks, it is important to see your doctor again for further advice.
Can I use other creams and moisturisers with tacrolimus ointment?
Yes, you can continue to use moisturising creams and lotions while being treated with tacrolimus. However, you should wait at least two hours after applying tacrolimus ointment before putting on other products.
Why can't I cover the treated area with dressings or bandages?
You should not cover skin treated with tacrolimus with dressings or bandages. This is because doing so could lead to more of the medicine being absorbed by your skin than intended.
What should I do if I experience a burning sensation when I apply the ointment?
A burning sensation is a very common side-effect of tacrolimus ointment. These symptoms generally disappear within one week as your body adjusts to the medicine. If it continues or becomes troublesome, you should speak with your doctor or pharmacist.
I've heard that tacrolimus is also taken by mouth. Is this the same medicine?
While tacrolimus is available as a medicine taken by mouth, this form is prescribed for a completely different medical condition, specifically to prevent organ rejection. The ointment is only for use on the skin.
قراءة إضافية ومراجع
- Manufacturer's PIL, Protopic® 0.1% Ointment; Leo Laboratories Ltd, The electronic Medicines Compendium. Dated June 2021.
- Manufacturer's PIL, Protopic® 0.03% ointment; Leo Laboratories Ltd, The electronic Medicines Compendium. Dated June 2021.
- الأدوية كاملة BNF الطبعة 89; الجمعية الطبية البريطانية والجمعية الملكية الصيدلانية لبريطانيا العظمى، لندن.
تابع القراءة أدناه
About the authorView full bio

مايكل ستيوارت، MRPharmS
Medicine Leaflet Review Manager – Contractor, Pharmacist
BPharm (Hons), MRPharmS
Michael is a community pharmacist practicing in the Midlands and South Yorkshire with more than 20 years’ experience advising on medicines and medical conditions. He has a strong background in healthcare training, having produced and delivered training courses for pharmacy teams and staff of residential care settings, including nurses. He has also contributed to pharmacy advisory boards for the management of low acuity conditions in the community.
About the reviewer

سيد داجاني
Sultan Dajani qualified at the London School of Pharmacy in 1994 and became the youngest elected member of the Royal Pharmaceutical Society council since its founding in 1842.
تاريخ المقال
تمت كتابة المعلومات على هذه الصفحة ومراجعتها من قبل أطباء مؤهلين.
المراجعة التالية مستحقة: 13 أغسطس 2026
14 أغسطس 2023 | أحدث إصدار

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