Gastrointestinal malabsorption

What are the symptoms of gastrointestinal malabsorption?

There may be no symptoms if the malabsorption is mild and has not continued for very long. More severe or persistent malabsorption may lead to:

Tiredness (fatigue)

This is because of a lack of energy as you are not absorbing nutrients and essential vitamins and minerals from food.

فقدان الوزن

If you can't absorb enough energy (calories) from your food then this will cause you to lose weight (and may cause poor growth in children).

Persistent (chronic) diarrhoea

This is a common symptom of persistent malabsorption.

Pale, bulky and smelly stools (steatorrhoea)

This is because there is excessive fat in the stools and they become pale, bulky and very smelly. Fatty stools float and are difficult to flush away. They often leave a greasy rim around the pan.

Intestinal malabsorption may also cause:

• Iron deficiency و فقر الدم الناجم عن نقص الحديد.

• Folate deficiency.

• Vitamin B12 deficiency.

• Abnormal bleeding, caused by low vitamin K.

• Vitamin D deficiency including rickets and osteomalacia.

• Oedema, which occurs because of insufficient protein and calories absorbed into the body.

There may also be other symptoms due to the particular underlying condition that is causing the malabsorption.

The most common causes in the UK are مرض السيلياك, مرض كرون and chronic pancreatitis. However, the malabsorption of simple carbohydrates affects about 1 in 4 people in Europe. Some diseases associated with malabsorption are found more often in some families - for example, coeliac disease, Crohn's disease, التليف الكيسي and lactose intolerance.

The causes of gastrointestinal malabsorption include:

Problems with absorbing food from the gut (bowel) into your body

• مرض السيلياك - a long-term disease that mostly affects the small intestine.

• عدم تحمل اللاكتوز.

• حساسية بروتين حليب البقر.

• Soya milk intolerance.

• Fructose intolerance.

• Infection - for example, intestinal tuberculosis, traveller's diarrhoea.

• Immune deficiency - for example, عدوى فيروس نقص المناعة البشرية.

• Pancreatic insufficiency - for example, التليف الكيسي, التهاب البنكرياس المزمن, سرطان البنكرياس.

• Bile salts and acid malabsorption.

Structural causes

Malabsorption may be cause by loss of part of the bowel that is essential to absorb the broken down (digested) food into the body - for example:

• Removal of the stomach or part of the bowel after a stomach or bowel operation.

• مرض كرون.

Causes outside the bowel

تشمل الأمثلة:

• An overactive thyroid gland (hyperthyroidism).

• Eating disorders: anorexia nervosa, bulimia nervosa.

Initial tests will include اختبارات الدم و stool tests. Further tests may include an abdominal الموجات فوق الصوتية, barium studies and a التصوير المقطعي المحوسب (CT) or a فحص التصوير بالرنين المغناطيسي (MRI). Any further tests will depend on the likely underlying cause of the intestinal malabsorption.

The treatment will mainly depend on the underlying cause of the malabsorption. However, treatment will also be needed to increase the amount of essential nutrients in the body, including carbohydrates, proteins, fats, minerals and fat-soluble vitamins (nutritional support).